SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3chm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1498_1 (CYTOCHROME P450 3A4)	3chm	COP9 SIGNALOSOME COMPLEX SUBUNIT 7 (Arabidopsis thaliana)	5 / 12	LEU A 68 LEU A 65 PHE A 69 ALA A 81 THR A 82	None	1.22A	2v0mC-3chmA: undetectable	2v0mC-3chmA: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_B_CHDB1_0 (FERROCHELATASE, MITOCHONDRIAL)	3chm	COP9 SIGNALOSOME COMPLEX SUBUNIT 7 (Arabidopsis thaliana)	4 / 4	LEU A 84 PRO A 85 LEU A 65 ARG A 67	None	1.29A	3hcoB-3chmA: undetectable	3hcoB-3chmA: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_A_RCXA601_2 (PROSTAGLANDIN G/H SYNTHASE 2)	3chm	COP9 SIGNALOSOME COMPLEX SUBUNIT 7 (Arabidopsis thaliana)	3 / 3	ARG A 160 ILE A 140 PHE A 40	None	0.54A	5kirA-3chmA: undetectable	5kirA-3chmA: 15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMD_A_YMZA3801_1 (60S RIBOSOMAL PROTEIN L28 28S RIBOSOMAL RNA 60S RIBOSOMAL PROTEIN L4)	3chm	COP9 SIGNALOSOME COMPLEX SUBUNIT 7 (Arabidopsis thaliana)	4 / 6	ASN A 80 ALA A 81 PRO A 85 TYR A 77	None	1.19A	5umd2-3chmA: undetectable 5umdF-3chmA: undetectable	5umd2-3chmA: 20.24 5umdF-3chmA: 16.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V0M_C_KLNC1498_1","CYTOCHROME P450 3A4","3chm","COP9 SIGNALOSOME COMPLEX SUBUNIT 7","Arabidopsis thaliana",5,"LEU A  68;LEU A  65;PHE A  69;ALA A  81;THR A  82","None","1.22A","2v0mC-3chmA:undetectable","2v0mC-3chmA:18.34"],["3HCO_B_CHDB1_0","FERROCHELATASE, MITOCHONDRIAL","3chm","COP9 SIGNALOSOME COMPLEX SUBUNIT 7","Arabidopsis thaliana",4,"LEU A  84;PRO A  85;LEU A  65;ARG A  67","None","1.29A","3hcoB-3chmA:undetectable","3hcoB-3chmA:19.52"],["5KIR_A_RCXA601_2","PROSTAGLANDIN G\/H SYNTHASE 2","3chm","COP9 SIGNALOSOME COMPLEX SUBUNIT 7","Arabidopsis thaliana",3,"ARG A 160;ILE A 140;PHE A  40","None","0.54A","5kirA-3chmA:undetectable","5kirA-3chmA:15.59"],["5UMD_A_YMZA3801_1","60S RIBOSOMAL PROTEIN L28;28S RIBOSOMAL RNA;60S RIBOSOMAL PROTEIN L4","3chm","COP9 SIGNALOSOME COMPLEX SUBUNIT 7","Arabidopsis thaliana",4,"ASN A  80;ALA A  81;PRO A  85;TYR A  77","None","1.19A","5umd2-3chmA:undetectable;5umdF-3chmA:undetectable","5umd2-3chmA:20.24;5umdF-3chmA:16.36"]]