SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3chv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 7 HIS A  53
GLY A  89
GLY A  90
TYR A 123
 ZN  A 302 (-3.2A)
None
None
None
 0.94A 1ekjE-3chvA:
undetectable
1ekjF-3chvA:
undetectable		 1ekjE-3chvA:
21.09
1ekjF-3chvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 HIS A  53
SER A  18
TYR A 123
PHE A 118
 ZN  A 302 (-3.2A)
None
None
None
 1.13A 1eqbA-3chvA:
undetectable
1eqbB-3chvA:
undetectable		 1eqbA-3chvA:
23.31
1eqbB-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 HIS A  53
SER A  92
TYR A 123
PHE A 118
 ZN  A 302 (-3.2A)
None
None
None
 1.07A 1eqbA-3chvA:
undetectable
1eqbB-3chvA:
undetectable		 1eqbA-3chvA:
23.31
1eqbB-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  18
 None
None
ZN  A 302 (-3.2A)
None
 1.15A 1eqbA-3chvA:
undetectable
1eqbB-3chvA:
undetectable		 1eqbA-3chvA:
23.31
1eqbB-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  92
 None
None
ZN  A 302 (-3.2A)
None
 1.07A 1eqbA-3chvA:
undetectable
1eqbB-3chvA:
undetectable		 1eqbA-3chvA:
23.31
1eqbB-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 HIS A  53
SER A  18
TYR A 123
PHE A 118
 ZN  A 302 (-3.2A)
None
None
None
 1.14A 1eqbC-3chvA:
undetectable
1eqbD-3chvA:
undetectable		 1eqbC-3chvA:
23.31
1eqbD-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 HIS A  53
SER A  92
TYR A 123
PHE A 118
 ZN  A 302 (-3.2A)
None
None
None
 1.07A 1eqbC-3chvA:
undetectable
1eqbD-3chvA:
undetectable		 1eqbC-3chvA:
23.31
1eqbD-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  18
 None
None
ZN  A 302 (-3.2A)
None
 1.16A 1eqbC-3chvA:
undetectable
1eqbD-3chvA:
undetectable		 1eqbC-3chvA:
23.31
1eqbD-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 TYR A 123
PHE A 118
HIS A  53
SER A  92
 None
None
ZN  A 302 (-3.2A)
None
 1.07A 1eqbC-3chvA:
undetectable
1eqbD-3chvA:
undetectable		 1eqbC-3chvA:
23.31
1eqbD-3chvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		5 / 10 THR A 230
HIS A  51
ALA A  47
ASN A 247
ALA A  42
 None
ZN  A 302 (-3.2A)
None
None
None
 0.98A 1likA-3chvA:
undetectable		 1likA-3chvA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		3 / 3 GLU A 233
HIS A  51
HIS A  53
 ZN  A 302 (-2.2A)
ZN  A 302 (-3.2A)
ZN  A 302 (-3.2A)
 0.65A 1oe2A-3chvA:
undetectable		 1oe2A-3chvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 LEU A 133
ALA A 109
GLY A  89
PHE A  68
 None
 0.74A 1sv9A-3chvA:
undetectable		 1sv9A-3chvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 6 PHE A 149
VAL A 175
PHE A 118
SER A  18
 None
 1.06A 1wrlB-3chvA:
undetectable		 1wrlB-3chvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 TYR A 123
HIS A  53
GLU A 233
HIS A  51
 None
ZN  A 302 (-3.2A)
ZN  A 302 (-2.2A)
ZN  A 302 (-3.2A)
 0.87A 2bnnA-3chvA:
undetectable
2bnnB-3chvA:
undetectable		 2bnnA-3chvA:
21.53
2bnnB-3chvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 TYR A 123
SER A 112
HIS A  51
SER A 110
 None
None
ZN  A 302 (-3.2A)
None
 1.21A 2vmyA-3chvA:
undetectable
2vmyB-3chvA:
undetectable		 2vmyA-3chvA:
20.48
2vmyB-3chvA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		5 / 10 THR A 228
GLY A 209
VAL A 175
GLU A 145
ILE A 210
 None
 1.22A 3uayA-3chvA:
undetectable		 3uayA-3chvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		5 / 9 ASP A  57
ILE A  30
THR A  16
GLY A  17
ARG A 121
 None
None
None
ZN  A 302 ( 4.7A)
None
 1.02A 4acaB-3chvA:
4.0
4acaC-3chvA:
4.0		 4acaB-3chvA:
18.57
4acaC-3chvA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 6 ARG A  55
ASP A 234
GLN A 214
GLU A 145
 None
 1.46A 4azvA-3chvA:
undetectable		 4azvA-3chvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 8 ALA A 244
SER A 246
LEU A 232
ARG A 253
 None
 1.21A 4ijiF-3chvA:
undetectable		 4ijiF-3chvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		4 / 6 SER A 110
GLU A 145
GLN A  85
THR A  16
 None
 1.26A 4lnxA-3chvA:
undetectable		 4lnxA-3chvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD
(Ruegeria
pomeroyi) 		5 / 9 GLY A 209
ILE A 154
LEU A 151
ARG A 186
ASP A 190
 None
 1.33A 6c2mC-3chvA:
undetectable		 6c2mC-3chvA:
14.13