SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3chx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3chx PMOB
(Methylosinus
trichosporium) 		3 / 3 ASP A 394
LEU A 388
LEU A 391
 None
 0.61A 1ikeA-3chxA:
undetectable		 1ikeA-3chxA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3chx PMOB
(Methylosinus
trichosporium) 		4 / 8 THR A 361
LEU A 359
VAL A 317
VAL A 295
 None
 0.98A 1iwiA-3chxA:
undetectable		 1iwiA-3chxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3chx PMOA
PMOB
PMOC
(Methylosinus
trichosporium) 		5 / 12 ARG C 138
ILE C 137
ASP C  52
ILE A 158
THR B 196
 None
 1.35A 1kijA-3chxC:
undetectable		 1kijA-3chxC:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3chx PMOB
(Methylosinus
trichosporium) 		3 / 3 ASP A 394
LEU A 388
LEU A 391
 None
 0.61A 1np1B-3chxA:
undetectable		 1np1B-3chxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3chx PMOB
(Methylosinus
trichosporium) 		4 / 6 PHE A  95
ASN A 150
ASN A  97
ARG A 107
 None
 0.90A 1oniA-3chxA:
undetectable
1oniB-3chxA:
undetectable		 1oniA-3chxA:
16.97
1oniB-3chxA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3chx PMOB
(Methylosinus
trichosporium) 		4 / 6 PHE A  95
ASN A 150
ASN A  97
ARG A 107
 None
 0.97A 1oniD-3chxA:
undetectable
1oniF-3chxA:
undetectable		 1oniD-3chxA:
16.97
1oniF-3chxA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3chx PMOA
(Methylosinus
trichosporium) 		4 / 6 VAL B  57
SER B 122
PHE B 193
HIS B 192
 None
 1.21A 2f8dA-3chxB:
undetectable		 2f8dA-3chxB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3chx PMOB
PMOA
(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		4 / 5 PRO B  91
PHE B  84
PHE B  92
ILE A 219
 None
 1.09A 2hjhA-3chxB:
undetectable		 2hjhA-3chxB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3chx PMOA
(Methylosinus
trichosporium) 		5 / 12 PHE B  46
TYR B  42
ASN B 164
LEU B 160
ALA B  77
 None
 1.39A 2iyfB-3chxB:
undetectable		 2iyfB-3chxB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3chx PMOA
PMOB
(Methylosinus
trichosporium) 		4 / 7 ARG A 119
ASP B 187
PHE A 116
GLN A 276
 None
 1.26A 2jc9A-3chxA:
undetectable		 2jc9A-3chxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 3chx PMOA
PMOC
(Methylosinus
trichosporium) 		4 / 4 GLU B 206
ASP C 141
HIS C 146
GLU C 149
 None
None
CU  C 661 (-3.1A)
None
 1.34A 2x45A-3chxB:
0.0		 2x45A-3chxB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3chx PMOB
PMOC
(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		4 / 8 THR C 140
ASP C 139
SER A  44
TYR A 393
 None
 1.29A 2xz5A-3chxC:
undetectable
2xz5C-3chxC:
undetectable		 2xz5A-3chxC:
16.22
2xz5C-3chxC:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3chx PMOB
(Methylosinus
trichosporium) 		5 / 11 GLY A 168
ILE A 164
LEU A  66
VAL A  68
ALA A 137
 None
 0.95A 3dcmX-3chxA:
undetectable		 3dcmX-3chxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3chx PMOB
(Methylosinus
trichosporium) 		3 / 3 HIS A 146
HIS A  40
HIS A 144
 CU  A 711 ( 3.5A)
CU  A 712 ( 3.4A)
CU  A 711 (-3.7A)
 0.67A 3mihA-3chxA:
undetectable		 3mihA-3chxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3chx PMOB
(Methylosinus
trichosporium) 		6 / 12 LEU A 311
ASN A  55
GLY A 400
ALA A  47
LEU A 391
LEU A 299
 None
 1.38A 3p5nB-3chxA:
undetectable		 3p5nB-3chxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3chx PMOB
(Methylosinus
trichosporium) 		4 / 4 PHE A 406
TYR A  57
ILE A 374
LEU A 366
 None
 1.47A 3sudA-3chxA:
undetectable		 3sudA-3chxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3chx PMOC
(Methylosinus
trichosporium) 		3 / 3 TYR C 157
GLU C  69
TYR C 151
 None
 0.83A 3ug8A-3chxC:
undetectable		 3ug8A-3chxC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3chx PMOA
PMOB
(Methylosinus
trichosporium) 		5 / 12 LEU B 172
LEU B 185
LEU A 187
ILE A 195
ILE B 121
 None
 1.15A 4j24A-3chxB:
undetectable		 4j24A-3chxB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3chx PMOA
PMOB
(Methylosinus
trichosporium) 		5 / 12 LEU B 172
LEU B 185
LEU A 187
ILE A 195
ILE B 121
 None
 1.16A 4j24B-3chxB:
undetectable		 4j24B-3chxB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 3chx PMOA
(Methylosinus
trichosporium) 		5 / 12 LEU B 235
GLN B  81
ALA B  94
GLY B 153
LEU B 136
 None
 1.29A 4j7xB-3chxB:
undetectable		 4j7xB-3chxB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3chx PMOA
(Methylosinus
trichosporium) 		5 / 11 PHE B  46
TYR B  42
ASN B 164
LEU B 160
ALA B  77
 None
 1.43A 4m83A-3chxB:
undetectable		 4m83A-3chxB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3chx PMOC
(Methylosinus
trichosporium) 		5 / 9 ALA C 117
TYR C 119
PHE C 125
SER C 123
GLY C 121
 None
 1.30A 4mmeA-3chxC:
undetectable		 4mmeA-3chxC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3chx PMOA
PMOC
(Methylosinus
trichosporium) 		5 / 12 GLY C 121
ALA C 122
LEU B  39
GLU C 127
ASN B 112
 None
 1.36A 4pb1A-3chxC:
undetectable		 4pb1A-3chxC:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3chx PMOB
(Methylosinus
trichosporium) 		5 / 12 ALA A 147
GLY A  76
ALA A 332
GLY A 334
GLU A  42
 None
None
None
None
CU  A 712 (-3.4A)
 1.18A 4r29C-3chxA:
undetectable		 4r29C-3chxA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3chx PMOB
(Methylosinus
trichosporium) 		5 / 12 ALA A 147
GLY A  76
ALA A 332
GLY A 334
GLU A  42
 None
None
None
None
CU  A 712 (-3.4A)
 1.08A 4r29D-3chxA:
undetectable		 4r29D-3chxA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3chx PMOB
(Methylosinus
trichosporium) 		4 / 5 GLY A 334
ALA A 333
GLY A 159
PRO A 160
 None
 0.77A 4u9uA-3chxA:
undetectable		 4u9uA-3chxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3chx PMOB
(Methylosinus
trichosporium) 		4 / 5 GLY A 334
ALA A 333
GLY A 159
PRO A 160
 None
 0.77A 4u9uB-3chxA:
undetectable		 4u9uB-3chxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3chx PMOA
PMOB
PMOC
(Methylosinus
trichosporium) 		5 / 12 ARG C 138
ILE C 137
ASP C  52
ILE A 158
THR B 196
 None
 1.30A 4uroD-3chxC:
undetectable		 4uroD-3chxC:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3chx PMOA
PMOB
(Methylosinus
trichosporium) 		5 / 12 PHE A 214
PHE B  30
LEU B  31
ALA A 221
PHE B  83
 None
 1.11A 4wnwB-3chxA:
undetectable		 4wnwB-3chxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3chx PMOA
PMOB
(Methylosinus
trichosporium) 		5 / 12 PHE B  30
LEU B  31
ALA A 221
ASP B  27
PHE B  83
 None
 1.12A 4wnwB-3chxB:
undetectable		 4wnwB-3chxB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3chx PMOA
PMOC
(Methylosinus
trichosporium) 		5 / 12 GLU C 127
ILE B 107
GLY B 104
ILE B 103
TYR B  42
 None
 1.27A 5ifuA-3chxC:
undetectable		 5ifuA-3chxC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3chx PMOB
PMOA
(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		5 / 12 THR B 196
GLY A 102
PRO A 103
VAL A 104
PHE B 119
 None
 1.08A 5jo9A-3chxB:
undetectable		 5jo9A-3chxB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3chx PMOC
(Methylosinus
trichosporium) 		3 / 3 HIS C 146
ASP C 129
HIS C 133
 CU  C 661 (-3.1A)
CU  C 661 (-2.4A)
CU  C 661 (-3.2A)
 0.66A 5oexA-3chxC:
undetectable		 5oexA-3chxC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3chx PMOC
(Methylosinus
trichosporium) 		3 / 3 HIS C 146
ASP C 129
HIS C 133
 CU  C 661 (-3.1A)
CU  C 661 (-2.4A)
CU  C 661 (-3.2A)
 0.69A 5oexB-3chxC:
undetectable		 5oexB-3chxC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3chx PMOC
(Methylosinus
trichosporium) 		3 / 3 HIS C 146
ASP C 129
HIS C 133
 CU  C 661 (-3.1A)
CU  C 661 (-2.4A)
CU  C 661 (-3.2A)
 0.69A 5oexC-3chxC:
undetectable		 5oexC-3chxC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3chx PMOC
(Methylosinus
trichosporium) 		3 / 3 HIS C 146
ASP C 129
HIS C 133
 CU  C 661 (-3.1A)
CU  C 661 (-2.4A)
CU  C 661 (-3.2A)
 0.69A 5oexD-3chxC:
undetectable		 5oexD-3chxC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3chx PMOA
PMOB
(Methylosinus
trichosporium) 		4 / 7 LEU B 172
ALA B 170
THR A 268
ILE A 269
 None
 0.94A 5te8A-3chxB:
undetectable		 5te8A-3chxB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3chx PMOA
PMOC
(Methylosinus
trichosporium) 		3 / 3 LEU C 101
VAL B  23
ASP B  27
 None
 0.62A 5x23A-3chxC:
undetectable		 5x23A-3chxC:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3chx PMOA
(Methylosinus
trichosporium) 		5 / 12 PHE B  92
VAL B 130
VAL B  98
GLY B 100
LEU B  31
 None
 1.11A 5x24A-3chxB:
undetectable		 5x24A-3chxB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3chx PMOB
(Methylosinus
trichosporium) 		5 / 12 PRO A 420
ILE A 399
LEU A 299
GLY A 301
GLY A 302
 None
 0.87A 5zhmB-3chxA:
undetectable		 5zhmB-3chxA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3chx PMOB
PMOA
(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		5 / 12 LEU B 123
PHE B 119
GLY A 102
ILE A 166
LEU A 105
 None
 1.00A 6dwnC-3chxB:
undetectable		 6dwnC-3chxB:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3chx PMOB
(Methylosinus
trichosporium) 		3 / 3 LYS A 277
SER A 120
SER A  93
 None
 1.14A 6gbfA-3chxA:
undetectable		 6gbfA-3chxA:
21.75