SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 4 HIS A  96
LEU A 114
LEU A 125
LEU A  74
 None
 1.22A 1a4lD-3ciaA:
undetectable		 1a4lD-3ciaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 8 LEU A 334
SER A 331
PHE A 349
GLY A 348
 None
 1.01A 1fapB-3ciaA:
undetectable		 1fapB-3ciaA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A 149
TRP A 177
TYR A 190
VAL A  61
 None
 1.31A 1ibgH-3ciaA:
undetectable		 1ibgH-3ciaA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.90A 1j36A-3ciaA:
6.7		 1j36A-3ciaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.90A 1j36B-3ciaA:
6.7		 1j36B-3ciaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.87A 1j37A-3ciaA:
5.1		 1j37A-3ciaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.88A 1j37B-3ciaA:
6.9		 1j37B-3ciaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 GLU A 554
HIS A 324
HIS A 328
GLU A 347
TYR A 410
 None
ZN  A 701 (-4.1A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 1.37A 1o86A-3ciaA:
5.7		 1o86A-3ciaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.86A 1o86A-3ciaA:
5.7		 1o86A-3ciaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 ASP A  92
LEU A  93
VAL A  94
ILE A  95
 None
 0.92A 1s9qA-3ciaA:
undetectable		 1s9qA-3ciaA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.83A 2c6nA-3ciaA:
4.1		 2c6nA-3ciaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.88A 2c6nB-3ciaA:
6.4		 2c6nB-3ciaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A  88
LEU A  74
PRO A 228
VAL A 188
 None
 1.05A 2dqyC-3ciaA:
undetectable		 2dqyC-3ciaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 VAL A 311
THR A 266
ILE A 307
SER A 305
PHE A 263
 None
 1.22A 2vdyA-3ciaA:
undetectable		 2vdyA-3ciaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.83A 2x8zA-3ciaA:
6.3		 2x8zA-3ciaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.82A 2x91A-3ciaA:
6.8		 2x91A-3ciaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 LEU A 529
PHE A 525
LEU A 562
SER A 563
VAL A 571
 None
 1.08A 3aqiB-3ciaA:
undetectable		 3aqiB-3ciaA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 ASN A  46
VAL A  50
THR A 129
ILE A 127
LEU A  88
 None
 1.34A 3bexC-3ciaA:
undetectable
3bexD-3ciaA:
undetectable		 3bexC-3ciaA:
17.47
3bexD-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 10 LEU A  88
ASN A  46
VAL A  50
THR A 129
ILE A 127
 None
 1.33A 3bexC-3ciaA:
undetectable
3bexD-3ciaA:
undetectable		 3bexC-3ciaA:
17.47
3bexD-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 10 ASN A  46
VAL A  50
THR A 129
ILE A 127
LEU A  88
 None
 1.33A 3bexE-3ciaA:
undetectable
3bexF-3ciaA:
undetectable		 3bexE-3ciaA:
17.47
3bexF-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 LEU A  88
ASN A  46
VAL A  50
THR A 129
ILE A 127
 None
 1.33A 3bexE-3ciaA:
undetectable
3bexF-3ciaA:
undetectable		 3bexE-3ciaA:
17.47
3bexF-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 ASN A  46
VAL A  50
THR A 129
ILE A 127
LEU A  88
 None
 1.33A 3bf1A-3ciaA:
undetectable
3bf1B-3ciaA:
undetectable		 3bf1A-3ciaA:
17.47
3bf1B-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 ASN A  46
VAL A  50
THR A 129
ILE A 127
LEU A  88
 None
 1.34A 3bf1C-3ciaA:
2.0
3bf1D-3ciaA:
undetectable		 3bf1C-3ciaA:
17.47
3bf1D-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 LEU A  88
ASN A  46
VAL A  50
THR A 129
ILE A 127
 None
 1.33A 3bf1C-3ciaA:
2.0
3bf1D-3ciaA:
undetectable		 3bf1C-3ciaA:
17.47
3bf1D-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 ASN A  46
VAL A  50
THR A 129
ILE A 127
LEU A  88
 None
 1.33A 3bf1E-3ciaA:
2.0
3bf1F-3ciaA:
undetectable		 3bf1E-3ciaA:
17.47
3bf1F-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 LEU A  88
ASN A  46
VAL A  50
THR A 129
ILE A 127
 None
 1.32A 3bf1E-3ciaA:
undetectable
3bf1F-3ciaA:
undetectable		 3bf1E-3ciaA:
17.47
3bf1F-3ciaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		3 / 3 ARG A 214
GLU A 239
ASP A 257
 None
 0.86A 3g2oA-3ciaA:
undetectable		 3g2oA-3ciaA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 LEU A 529
PHE A 525
LEU A 562
SER A 563
VAL A 571
 None
 1.08A 3w1wA-3ciaA:
undetectable		 3w1wA-3ciaA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 ASP A 315
SER A 317
GLU A 521
HIS A 520
 None
 1.29A 4aq7A-3ciaA:
undetectable		 4aq7A-3ciaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 VAL A 608
TYR A 578
LEU A 595
TYR A 572
 None
 1.14A 4b3qA-3ciaA:
undetectable		 4b3qA-3ciaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 HIS A 324
GLU A 325
HIS A 328
GLU A 347
TYR A 410
 ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
ZN  A 701 (-3.4A)
None
 0.93A 4c2pA-3ciaA:
5.8		 4c2pA-3ciaA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		7 / 9 GLY A 297
HIS A 324
GLU A 325
GLU A 347
TYR A 410
ARG A 584
LYS A 586
 None
ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.4A)
None
None
None
 0.53A 4dprA-3ciaA:
47.2		 4dprA-3ciaA:
37.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 11 TYR A 280
ILE A 226
SER A 205
THR A 247
LEU A 230
 None
 1.37A 4kysB-3ciaA:
0.0		 4kysB-3ciaA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 TYR A 229
ILE A 180
ILE A 178
ALA A 174
 None
 0.75A 4lv9A-3ciaA:
undetectable		 4lv9A-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 VAL A 188
ILE A 180
ILE A 178
ALA A 174
 None
 0.66A 4lv9A-3ciaA:
undetectable		 4lv9A-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 TYR A 229
ILE A 180
ILE A 178
ALA A 174
 None
 0.76A 4lv9B-3ciaA:
undetectable		 4lv9B-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 VAL A 188
ILE A 180
ILE A 178
ALA A 174
 None
 0.70A 4lv9B-3ciaA:
undetectable		 4lv9B-3ciaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 LYS A 586
ASN A 320
GLU A 554
ARG A 584
 None
 1.28A 4mv7A-3ciaA:
undetectable		 4mv7A-3ciaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 TYR A 410
GLU A 354
VAL A 361
ALA A 360
 None
 1.14A 4nkvC-3ciaA:
undetectable		 4nkvC-3ciaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A 417
HIS A 328
HIS A 324
GLU A 347
 None
ZN  A 701 (-3.8A)
ZN  A 701 (-4.1A)
ZN  A 701 (-3.4A)
 1.00A 4pahA-3ciaA:
undetectable		 4pahA-3ciaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		3 / 3 PRO A 573
MET A 575
TYR A 572
 None
 1.02A 4qa0B-3ciaA:
undetectable		 4qa0B-3ciaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		3 / 3 PRO A 573
MET A 575
TYR A 572
 None
 1.02A 4qa0A-3ciaA:
undetectable		 4qa0A-3ciaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		3 / 3 PRO A 573
MET A 575
TYR A 572
 None
 0.80A 4qa2B-3ciaA:
undetectable		 4qa2B-3ciaA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		9 / 12 GLN A 170
ALA A 171
HIS A 324
GLU A 325
HIS A 328
TRP A 340
GLU A 347
LEU A 396
TYR A 410
 None
None
ZN  A 701 (-4.1A)
ZN  A 701 ( 4.6A)
ZN  A 701 (-3.8A)
None
ZN  A 701 (-3.4A)
None
None
 0.58A 4r7lA-3ciaA:
53.1		 4r7lA-3ciaA:
37.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 PHE A 429
ILE A 475
LEU A 454
PHE A 450
 None
 0.81A 4uymA-3ciaA:
1.2		 4uymA-3ciaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 PHE A 429
ILE A 475
LEU A 454
PHE A 450
 None
 0.78A 4uymB-3ciaA:
undetectable		 4uymB-3ciaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 8 ASN A 301
MET A 299
TRP A 282
TYR A 280
 None
 1.41A 4v2zB-3ciaA:
undetectable		 4v2zB-3ciaA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 8 ASN A 301
MET A 299
TRP A 282
TYR A 280
 None
 1.39A 4v30B-3ciaA:
undetectable		 4v30B-3ciaA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 GLU A 421
LEU A 420
LEU A 458
LEU A 454
 None
 0.73A 4wg0B-3ciaA:
undetectable
4wg0C-3ciaA:
undetectable		 4wg0B-3ciaA:
2.29
4wg0C-3ciaA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 LEU A 458
LEU A 454
GLU A 421
LEU A 420
 None
 0.79A 4wg0L-3ciaA:
undetectable
4wg0M-3ciaA:
undetectable		 4wg0L-3ciaA:
2.29
4wg0M-3ciaA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 THR A 364
ALA A 367
GLU A 370
MET A 276
PRO A 487
 None
 1.17A 4xi3D-3ciaA:
undetectable		 4xi3D-3ciaA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 GLY A 622
ASP A 625
ARG A 613
GLY A 618
 None
 0.81A 5cdnA-3ciaA:
2.5
5cdnB-3ciaA:
undetectable		 5cdnA-3ciaA:
22.19
5cdnB-3ciaA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 8 ASP A 546
ASP A 542
ILE A 555
TYR A 578
 None
 1.04A 5cfsA-3ciaA:
undetectable		 5cfsA-3ciaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 4 LEU A  76
TYR A 112
PRO A 179
ILE A 180
 None
 1.40A 5esgA-3ciaA:
undetectable		 5esgA-3ciaA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 GLU A 427
PHE A 429
TYR A 462
ILE A 465
 None
 0.85A 5kmfA-3ciaA:
1.9
5kmfC-3ciaA:
undetectable		 5kmfA-3ciaA:
18.78
5kmfC-3ciaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 9 LEU A 595
VAL A 624
GLY A 583
ILE A 582
PRO A 590
 None
 1.08A 5kqxB-3ciaA:
undetectable		 5kqxB-3ciaA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 PRO A 179
TYR A 140
ILE A  95
ILE A 127
 None
 0.87A 5murB-3ciaA:
3.9		 5murB-3ciaA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 10 ALA A  72
LEU A  74
LEU A  88
VAL A  98
ILE A 127
 None
 1.09A 5v02B-3ciaA:
undetectable
5v02R-3ciaA:
undetectable		 5v02B-3ciaA:
10.50
5v02R-3ciaA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 LEU A  57
VAL A 188
ALA A 232
LEU A 165
LEU A 149
 None
 1.06A 5x23A-3ciaA:
undetectable		 5x23A-3ciaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		3 / 3 LEU A 619
ASN A 301
LEU A 290
 None
 0.75A 6exiD-3ciaA:
undetectable		 6exiD-3ciaA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 9 LEU A 304
SER A 305
PHE A 306
LEU A 290
ASN A 169
 None
 1.44A 6ftpA-3ciaA:
undetectable
6ftpB-3ciaA:
undetectable		 6ftpA-3ciaA:
8.35
6ftpB-3ciaA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		5 / 12 ASN A 346
ASN A 333
TYR A 280
ILE A 357
PHE A 437
 None
 1.49A 6j20A-3ciaA:
0.0		 6j20A-3ciaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 7 GLY A 148
THR A 147
HIS A 617
ARG A 585
 None
 0.96A 6jnhA-3ciaA:
undetectable		 6jnhA-3ciaA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 GLY A 148
THR A 147
HIS A 617
ARG A 585
 None
 0.93A 6jogA-3ciaA:
undetectable		 6jogA-3ciaA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3cia COLD-ACTIVE
AMINOPEPTIDASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A 417
HIS A 328
HIS A 324
GLU A 347
 None
ZN  A 701 (-3.8A)
ZN  A 701 (-4.1A)
ZN  A 701 (-3.4A)
 0.99A 6pahA-3ciaA:
undetectable		 6pahA-3ciaA:
18.72