SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		4 / 8 ALA A 671
LEU A 669
LEU A 668
LEU A 459
 None
 0.88A 1ereE-3cioA:
undetectable		 1ereE-3cioA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		4 / 8 ALA A 671
LEU A 669
LEU A 668
LEU A 459
 None
 0.88A 1ereF-3cioA:
undetectable		 1ereF-3cioA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		4 / 4 LEU A 570
PRO A 618
LEU A 624
ARG A 629
 None
 1.23A 2hrcA-3cioA:
undetectable		 2hrcA-3cioA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 8 VAL A 512
THR A 551
PHE A 604
GLY A 607
ALA A 554
 None
 1.22A 3aruA-3cioA:
undetectable		 3aruA-3cioA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 8 VAL A 515
THR A 551
PHE A 604
GLY A 607
ALA A 554
 None
 1.29A 3aruA-3cioA:
undetectable		 3aruA-3cioA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		3 / 3 GLY A 674
GLY A 714
GLY A 452
 None
 0.40A 3bogC-3cioA:
undetectable		 3bogC-3cioA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		4 / 4 LEU A 570
PRO A 618
LEU A 624
ARG A 629
 None
 1.25A 3hcoB-3cioA:
3.8		 3hcoB-3cioA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		4 / 8 PHE A 604
ALA A 553
PHE A 609
ALA A 503
 None
 0.90A 3t3sD-3cioA:
undetectable		 3t3sD-3cioA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 12 PHE A 501
GLN A 558
ALA A 557
ALA A 554
ALA A 553
 None
 1.05A 4j6dA-3cioA:
undetectable		 4j6dA-3cioA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 12 PHE A 501
GLN A 558
ALA A 557
ALA A 554
ALA A 553
 None
 1.05A 4j6dB-3cioA:
undetectable		 4j6dB-3cioA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 12 PHE A 501
GLN A 558
ALA A 557
ALA A 554
ALA A 553
 None
 1.05A 4jbtA-3cioA:
undetectable		 4jbtA-3cioA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 11 ALA A 592
LEU A 591
GLU A 623
LEU A 625
ARG A 614
 None
 1.09A 4wg0K-3cioA:
undetectable
4wg0L-3cioA:
undetectable
4wg0M-3cioA:
undetectable		 4wg0K-3cioA:
6.51
4wg0L-3cioA:
6.51
4wg0M-3cioA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 12 LEU A 459
LEU A 669
ALA A 698
LEU A 700
ALA A 539
 None
 1.26A 4x1kA-3cioA:
undetectable
4x1kB-3cioA:
undetectable		 4x1kA-3cioA:
21.04
4x1kB-3cioA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		4 / 7 LEU A 587
THR A 648
THR A 537
LEU A 633
 None
 1.11A 5jq7B-3cioA:
undetectable		 5jq7B-3cioA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3cio TYROSINE-PROTEIN
KINASE ETK
(Escherichia
coli) 		5 / 6 ILE A 566
ALA A 637
LEU A 564
ILE A 601
TYR A 590
 None
 1.43A 5mvmB-3cioA:
undetectable
5mvmC-3cioA:
undetectable		 5mvmB-3cioA:
15.26
5mvmC-3cioA:
15.26