SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 0.96A 1fbyA-3cirB:
undetectable		 1fbyA-3cirB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 0.96A 1fbyB-3cirB:
undetectable		 1fbyB-3cirB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 8 PHE B  96
GLY B  66
LEU B  75
VAL B 213
 None
None
FES  B 244 ( 4.4A)
None
 1.23A 1gsfA-3cirB:
undetectable		 1gsfA-3cirB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 8 PHE B  96
GLY B  66
LEU B  75
VAL B 213
 None
None
FES  B 244 ( 4.4A)
None
 1.23A 1gsfB-3cirB:
undetectable		 1gsfB-3cirB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 8 PHE B  96
GLY B  66
LEU B  75
VAL B 213
 None
None
FES  B 244 ( 4.4A)
None
 1.23A 1gsfD-3cirB:
undetectable		 1gsfD-3cirB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 6 GLY B  41
ASP B  45
TYR B  53
TRP B  55
 None
 0.28A 1kf6M-3cirB:
undetectable
1kf6N-3cirB:
35.5		 1kf6M-3cirB:
17.45
1kf6N-3cirB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 1.01A 1xiuA-3cirB:
undetectable		 1xiuA-3cirB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		3 / 3 ALA B 115
GLY B 169
SER B 197
 None
 0.54A 2ivuA-3cirB:
undetectable		 2ivuA-3cirB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 0.98A 3fc6C-3cirB:
undetectable		 3fc6C-3cirB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		5 / 12 GLY B 152
PRO B  73
GLY B  63
ALA B 171
ILE B 149
 SF4  B 246 (-4.2A)
None
FES  B 244 (-3.7A)
SF4  B 246 ( 3.8A)
SF4  B 246 (-4.9A)
 1.12A 3ku1G-3cirB:
undetectable		 3ku1G-3cirB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 6 TRP B 202
ILE B 224
THR B 174
SER B 211
 None
F3S  B 245 ( 4.5A)
None
None
 1.10A 4iaqA-3cirB:
undetectable		 4iaqA-3cirB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		3 / 3 TYR B 142
ARG B 184
SER B 183
 None
 1.06A 4lf7I-3cirB:
undetectable
4lf7J-3cirB:
undetectable		 4lf7I-3cirB:
20.00
4lf7J-3cirB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		3 / 3 TYR B 142
ARG B 184
SER B 183
 None
 1.06A 4lf8I-3cirB:
undetectable
4lf8J-3cirB:
undetectable		 4lf8I-3cirB:
20.00
4lf8J-3cirB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 6 ASP B 101
VAL B  17
ASP B  18
ALA B  24
 None
 1.20A 4nedA-3cirB:
undetectable		 4nedA-3cirB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		3 / 3 SER B 211
ASP B 219
GLN B 226
 None
 0.92A 4oltA-3cirB:
undetectable
4oltB-3cirB:
undetectable		 4oltA-3cirB:
22.26
4oltB-3cirB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 6 SER B  35
LEU B  36
TYR B  84
LEU B  81
 None
 0.77A 4wozA-3cirB:
undetectable
4wozB-3cirB:
undetectable		 4wozA-3cirB:
24.06
4wozB-3cirB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT
(Escherichia
coli) 		4 / 6 THR B  34
ARG B  82
LEU B  81
ASP B  83
 None
 1.11A 5tdzA-3cirB:
undetectable		 5tdzA-3cirB:
20.19