SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 9 VAL A  58
LEU A 151
SER A 147
LEU A  31
ASP A 144
 None
 1.37A 2j2pB-3citA:
undetectable
2j2pC-3citA:
undetectable		 2j2pB-3citA:
19.73
2j2pC-3citA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 129
LEU A  51
GLY A  63
MET A  60
VAL A  58
 None
 1.49A 2q7lA-3citA:
undetectable		 2q7lA-3citA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 GLU A  67
LEU A 159
VAL A  50
ALA A  78
 None
 0.93A 3ax9A-3citA:
undetectable		 3ax9A-3citA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 12 LEU A 131
GLY A  63
GLY A  81
SER A  82
LEU A 110
ASN A 133
 None
None
None
GOL  A 177 ( 4.3A)
None
GOL  A 176 (-3.2A)
 1.49A 3cjtO-3citA:
undetectable		 3cjtO-3citA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 LEU A  65
GLN A  75
LEU A  66
GLU A  67
 None
 1.08A 3h5gB-3citA:
undetectable
3h5gC-3citA:
undetectable		 3h5gB-3citA:
11.39
3h5gC-3citA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 GLU A  67
LEU A 159
VAL A  50
ALA A  78
 None
 0.90A 3uniB-3citA:
undetectable		 3uniB-3citA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 SER A 138
ALA A 136
VAL A 135
 None
None
GOL  A 176 ( 4.8A)
 0.52A 4o2bA-3citA:
undetectable		 4o2bA-3citA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 SER A 138
ALA A 136
VAL A 135
 None
None
GOL  A 176 ( 4.8A)
 0.56A 4o2bC-3citA:
undetectable		 4o2bC-3citA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 LEU A 131
LEU A  51
ALA A  54
LEU A 155
LEU A 148
 None
 0.99A 4p65A-3citA:
undetectable
4p65B-3citA:
undetectable
4p65F-3citA:
undetectable
4p65H-3citA:
undetectable		 4p65A-3citA:
11.90
4p65B-3citA:
14.41
4p65F-3citA:
14.41
4p65H-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 LEU A 131
LEU A  51
ALA A  54
LEU A 148
LEU A 155
 None
 0.92A 4p65C-3citA:
undetectable
4p65D-3citA:
undetectable
4p65J-3citA:
undetectable
4p65L-3citA:
undetectable		 4p65C-3citA:
11.90
4p65D-3citA:
14.41
4p65J-3citA:
14.41
4p65L-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 LEU A 131
LEU A  51
ALA A  54
LEU A 155
LEU A 148
 None
 0.84A 4p65E-3citA:
undetectable
4p65F-3citA:
undetectable
4p65J-3citA:
undetectable
4p65L-3citA:
undetectable		 4p65E-3citA:
11.90
4p65F-3citA:
14.41
4p65J-3citA:
14.41
4p65L-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 LEU A 148
LEU A 155
LEU A 131
LEU A  51
ALA A  54
 None
 0.88A 4p65B-3citA:
undetectable
4p65D-3citA:
undetectable
4p65G-3citA:
undetectable
4p65H-3citA:
undetectable		 4p65B-3citA:
14.41
4p65D-3citA:
14.41
4p65G-3citA:
11.90
4p65H-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 155
LEU A 148
LEU A 131
LEU A  51
ALA A  54
 None
 0.90A 4p65B-3citA:
undetectable
4p65D-3citA:
undetectable
4p65I-3citA:
undetectable
4p65J-3citA:
undetectable		 4p65B-3citA:
14.41
4p65D-3citA:
14.41
4p65I-3citA:
11.90
4p65J-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 148
LEU A 155
LEU A 131
LEU A  51
ALA A  54
 None
 0.98A 4p65F-3citA:
undetectable
4p65H-3citA:
undetectable
4p65K-3citA:
undetectable
4p65L-3citA:
undetectable		 4p65F-3citA:
14.41
4p65H-3citA:
14.41
4p65K-3citA:
11.90
4p65L-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 VAL A  58
HIS A  80
LEU A 110
ASN A 133
GLY A  81
 None
None
None
GOL  A 176 (-3.2A)
None
 1.21A 4qckA-3citA:
undetectable		 4qckA-3citA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3cit SENSOR HISTIDINE
KINASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 HIS A  80
ASN A 133
VAL A 113
HIS A  62
PRO A 111
 None
GOL  A 176 (-3.2A)
None
None
None
 1.47A 5z0mA-3citA:
undetectable
5z0mB-3citA:
undetectable		 5z0mA-3citA:
21.25
5z0mB-3citA:
20.13