SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ciy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 12 LEU A 492
LEU A 513
ASN A 516
GLN A 538
LEU A 485
 None
 1.39A 1a28B-3ciyA:
undetectable		 1a28B-3ciyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		6 / 12 ALA A 179
ASP A 203
LEU A 202
PHE A 212
LEU A 241
ALA A 231
 None
 1.12A 1ao8A-3ciyA:
undetectable		 1ao8A-3ciyA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 LEU A 321
SER A 295
ASN A 291
 None
None
NAG  A2911 (-1.9A)
 0.76A 1bx4A-3ciyA:
undetectable		 1bx4A-3ciyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 12 ALA A 179
ASP A 203
LEU A 202
LEU A 241
ALA A 231
 None
 0.94A 1bzfA-3ciyA:
undetectable		 1bzfA-3ciyA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 12 ALA A 179
ASP A 203
LEU A 202
PHE A 212
ALA A 231
 None
 0.86A 1bzfA-3ciyA:
undetectable		 1bzfA-3ciyA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 11 LEU A 384
ASN A 441
ILE A 419
LEU A 393
PHE A 401
 None
 1.32A 1tw4A-3ciyA:
undetectable		 1tw4A-3ciyA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 11 LEU A 404
ASN A 441
ILE A 419
LEU A 396
PHE A 427
 None
 1.33A 1tw4A-3ciyA:
undetectable		 1tw4A-3ciyA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 TRP A 546
LYS A 550
PRO A 578
 None
 1.09A 2dqyB-3ciyA:
undetectable		 2dqyB-3ciyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 ASN A 361
TYR A 307
SER A 304
 None
 0.75A 2gvcB-3ciyA:
undetectable		 2gvcB-3ciyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 ASN A 361
TYR A 307
SER A 304
 None
 0.72A 2gvcE-3ciyA:
undetectable		 2gvcE-3ciyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 LEU A  49
PRO A  50
ARG A  31
 None
 0.61A 2qd4B-3ciyA:
undetectable		 2qd4B-3ciyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 12 LEU A 357
LEU A 386
ILE A 367
MET A 362
PHE A 333
 None
 1.00A 2ygqA-3ciyA:
undetectable		 2ygqA-3ciyA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 5 GLN A 218
PHE A 217
LEU A 194
PHE A 193
 None
 1.47A 3ablC-3ciyA:
undetectable
3ablJ-3ciyA:
undetectable		 3ablC-3ciyA:
15.20
3ablJ-3ciyA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 5 GLN A 352
PHE A 351
LEU A 321
PHE A 294
 None
 1.33A 3ablC-3ciyA:
undetectable
3ablJ-3ciyA:
undetectable		 3ablC-3ciyA:
15.20
3ablJ-3ciyA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 7 GLN A 146
LEU A 152
LEU A 130
LEU A 128
 None
 0.82A 3bgdB-3ciyA:
undetectable		 3bgdB-3ciyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 ASP A 203
LEU A 177
GLN A 107
 None
 0.79A 3g4lA-3ciyA:
undetectable		 3g4lA-3ciyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 7 LEU A 617
LEU A 598
PRO A 578
ILE A 577
 None
 0.95A 3s56B-3ciyA:
undetectable		 3s56B-3ciyA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 6 MET A 642
LEU A 640
GLN A 635
PRO A 633
 None
 1.37A 3vkxA-3ciyA:
undetectable		 3vkxA-3ciyA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 12 LEU A 106
ASN A 109
LEU A 130
VAL A 103
THR A  59
 None
 1.40A 3zqtA-3ciyA:
undetectable		 3zqtA-3ciyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 12 LEU A 535
LEU A 567
LEU A 588
GLN A 609
VAL A 581
 None
 1.42A 3zqtA-3ciyA:
undetectable		 3zqtA-3ciyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 11 LEU A 617
LEU A 569
ILE A 577
ILE A 591
PHE A 537
 None
 1.14A 4a7aA-3ciyA:
undetectable		 4a7aA-3ciyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 4 TRP A 452
LEU A 438
LEU A 396
THR A 426
 None
 1.40A 4bboD-3ciyA:
undetectable		 4bboD-3ciyA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 8 ILE A 435
ILE A 461
LEU A 482
ILE A 458
 None
 0.87A 4dtaB-3ciyA:
undetectable		 4dtaB-3ciyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 6 ILE A  45
ILE A  87
PHE A  71
LEU A  80
 NDG  A 724 (-4.3A)
None
None
None
 0.99A 4m51A-3ciyA:
undetectable		 4m51A-3ciyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 PRO A  99
LEU A  98
GLN A  76
 None
 0.68A 4pevB-3ciyA:
undetectable		 4pevB-3ciyA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 9 ASN A 441
ILE A 443
GLY A 439
SER A 514
VAL A 490
 None
 1.11A 4r20B-3ciyA:
undetectable		 4r20B-3ciyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 8 PHE A 217
ARG A 187
ALA A 185
LEU A 186
 None
 0.93A 4rkuA-3ciyA:
undetectable
4rkuJ-3ciyA:
undetectable		 4rkuA-3ciyA:
21.47
4rkuJ-3ciyA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 7 PHE A 217
ARG A 187
ALA A 185
LEU A 186
 None
 0.99A 4xk8A-3ciyA:
undetectable		 4xk8A-3ciyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 10 SER A  88
LEU A 104
LEU A  80
LEU A  66
LEU A  98
 A  D  45 ( 4.3A)
None
None
None
None
 1.18A 4yiaA-3ciyA:
undetectable		 4yiaA-3ciyA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 10 SER A 213
LEU A 226
LEU A 204
LEU A 186
LEU A 176
 None
 1.20A 4yiaA-3ciyA:
undetectable		 4yiaA-3ciyA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 PHE A 582
ILE A 577
ASP A 628
 None
 0.72A 5cswB-3ciyA:
undetectable		 5cswB-3ciyA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		3 / 3 PRO A 504
ILE A 534
SER A 474
 None
 0.81A 5fsaA-3ciyA:
undetectable		 5fsaA-3ciyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		5 / 9 LEU A 558
LEU A 588
ILE A 591
PRO A 633
LEU A 612
 None
 1.06A 5g48B-3ciyA:
undetectable		 5g48B-3ciyA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 6 LEU A 128
LEU A  80
PHE A 119
LEU A  90
 None
 0.86A 5gs4A-3ciyA:
undetectable		 5gs4A-3ciyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 5 LEU A 128
LEU A  80
PHE A 119
LEU A  90
 None
 0.85A 5gtrA-3ciyA:
undetectable		 5gtrA-3ciyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 4 ASN A 109
LEU A 111
SER A 132
LEU A 154
 None
 1.11A 5kb5A-3ciyA:
undetectable		 5kb5A-3ciyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 8 LEU A 485
GLU A 451
LEU A 469
ILE A 443
 None
 0.75A 5mzjA-3ciyA:
undetectable		 5mzjA-3ciyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ciy TOLL-LIKE RECEPTOR 3
(Mus
musculus) 		4 / 6 GLN A 218
PHE A 217
LEU A 194
PHE A 193
 None
 1.33A 6nmpC-3ciyA:
undetectable
6nmpJ-3ciyA:
undetectable		 6nmpC-3ciyA:
15.20
6nmpJ-3ciyA:
6.13