SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cjw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3cjw COUP TRANSCRIPTION
FACTOR 2
(Homo
sapiens) 		5 / 11 LEU A 320
LEU A 252
LEU A 367
LEU A 370
THR A 248
 None
 1.31A 1tz8A-3cjwA:
undetectable
1tz8B-3cjwA:
undetectable		 1tz8A-3cjwA:
19.38
1tz8B-3cjwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3cjw COUP TRANSCRIPTION
FACTOR 2
(Homo
sapiens) 		5 / 12 VAL A 307
LEU A 367
LEU A 363
LEU A 252
LEU A 302
 None
 0.94A 1ya4C-3cjwA:
undetectable		 1ya4C-3cjwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3cjw COUP TRANSCRIPTION
FACTOR 2
(Homo
sapiens) 		4 / 7 PHE A 382
PHE A 253
ILE A 212
ASN A 211
 None
 1.06A 2zseA-3cjwA:
undetectable		 2zseA-3cjwA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3cjw COUP TRANSCRIPTION
FACTOR 2
(Homo
sapiens) 		5 / 12 ALA A 257
LEU A 386
ALA A 216
LEU A 220
LEU A 395
 None
 1.11A 3r9cA-3cjwA:
undetectable		 3r9cA-3cjwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3cjw COUP TRANSCRIPTION
FACTOR 2
(Homo
sapiens) 		5 / 9 LEU A 245
ALA A 227
LEU A 236
THR A 248
LEU A 252
 None
 1.38A 4ltwA-3cjwA:
15.4		 4ltwA-3cjwA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3cjw COUP TRANSCRIPTION
FACTOR 2
(Homo
sapiens) 		5 / 12 ALA A 223
TYR A 312
VAL A 307
LEU A 367
LEU A 370
 None
 1.10A 4qzuC-3cjwA:
undetectable		 4qzuC-3cjwA:
19.11