SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		4 / 8 ALA A 233
LEU A 254
GLY A 201
GLY A 192
 None
 0.79A 1rukH-3cjyA:
undetectable
1rukL-3cjyA:
undetectable		 1rukH-3cjyA:
23.10
1rukL-3cjyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 153
GLY A 154
GLY A 155
ASP A 241
GLY A 244
 None
None
None
None
GOL  A 263 (-3.1A)
 0.93A 1sqfA-3cjyA:
undetectable		 1sqfA-3cjyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 10 PRO A   6
PHE A   5
ALA A 178
PHE A 183
MET A 182
 None
 1.37A 2d06B-3cjyA:
undetectable		 2d06B-3cjyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 9 GLY A 250
THR A 249
ALA A 248
LEU A  44
LEU A 247
 None
 1.30A 2npnA-3cjyA:
undetectable		 2npnA-3cjyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 10 PHE A  35
ALA A  38
ALA A 181
LEU A 239
VAL A 237
 None
None
None
None
GOL  A 261 ( 4.5A)
 1.24A 2wuzA-3cjyA:
undetectable		 2wuzA-3cjyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 10 PHE A  35
ALA A 181
LEU A 239
MET A 223
VAL A 237
 None
None
None
None
GOL  A 261 ( 4.5A)
 1.17A 2wuzA-3cjyA:
undetectable		 2wuzA-3cjyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 10 PHE A  35
ALA A  38
ALA A 181
LEU A 239
VAL A 237
 None
None
None
None
GOL  A 261 ( 4.5A)
 1.23A 2wuzB-3cjyA:
undetectable		 2wuzB-3cjyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 10 PHE A  35
ALA A 181
LEU A 239
MET A 223
VAL A 237
 None
None
None
None
GOL  A 261 ( 4.5A)
 1.16A 2wuzB-3cjyA:
undetectable		 2wuzB-3cjyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 10 TYR A 144
ALA A 181
LEU A 239
MET A 223
VAL A 237
 None
None
None
None
GOL  A 261 ( 4.5A)
 1.44A 2wuzB-3cjyA:
undetectable		 2wuzB-3cjyA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 100
LEU A  60
LEU A  44
ALA A  43
VAL A  20
 None
 1.21A 3cwkA-3cjyA:
2.8		 3cwkA-3cjyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		4 / 8 PHE A  35
ALA A  38
ALA A 181
LEU A 239
 None
 0.97A 3l4dA-3cjyA:
undetectable		 3l4dA-3cjyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		3 / 3 ASP A  45
LEU A  74
VAL A  78
 None
 0.62A 4jecB-3cjyA:
undetectable		 4jecB-3cjyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A 219
ALA A 213
GLY A 212
THR A 211
ALA A 248
 None
 1.27A 4qvyV-3cjyA:
undetectable
4qvyW-3cjyA:
undetectable		 4qvyV-3cjyA:
21.90
4qvyW-3cjyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A 219
ALA A 213
GLY A 212
THR A 211
ALA A 248
 None
 1.26A 4qw1H-3cjyA:
undetectable
4qw1I-3cjyA:
undetectable		 4qw1H-3cjyA:
21.90
4qw1I-3cjyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A 219
ALA A 213
GLY A 212
THR A 211
ALA A 248
 None
 1.26A 4qw1V-3cjyA:
undetectable
4qw1W-3cjyA:
undetectable		 4qw1V-3cjyA:
21.90
4qw1W-3cjyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A 219
ALA A 213
GLY A 212
THR A 211
ALA A 248
 None
 1.27A 5cz7V-3cjyA:
undetectable
5cz7W-3cjyA:
undetectable		 5cz7V-3cjyA:
21.90
5cz7W-3cjyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 239
PRO A 136
LEU A 135
LEU A 167
CYH A 219
 None
 1.38A 5emlA-3cjyA:
undetectable		 5emlA-3cjyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A  43
LEU A  44
ALA A  41
PHE A   5
LEU A  24
 None
 1.16A 5k9dA-3cjyA:
undetectable		 5k9dA-3cjyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		5 / 9 LEU A  34
PRO A  67
GLY A  21
VAL A  94
LEU A  72
 None
 1.41A 5o96E-3cjyA:
undetectable
5o96F-3cjyA:
undetectable		 5o96E-3cjyA:
21.79
5o96F-3cjyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3cjy PUTATIVE
THIOESTERASE
(Novosphingobium
aromaticivorans) 		4 / 5 ARG A 168
ARG A 169
GLY A 172
ASP A 171
 None
 1.29A 6dwjB-3cjyA:
undetectable
6dwjD-3cjyA:
undetectable		 6dwjB-3cjyA:
18.86
6dwjD-3cjyA:
18.86