SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ck2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 8 TYR A  64
ASP A  59
SER A  39
HIS A  35
 None
 1.06A 2bteA-3ck2A:
undetectable		 2bteA-3ck2A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 8 TYR A  64
ASP A  59
SER A  39
HIS A  35
 None
 1.06A 2bteD-3ck2A:
undetectable		 2bteD-3ck2A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 8 TYR A  64
ASP A  59
SER A  39
HIS A  35
 None
 0.91A 2v0gA-3ck2A:
undetectable		 2v0gA-3ck2A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		3 / 3 HIS A  81
HIS A 110
HIS A  83
 MN  A 202 (-3.3A)
MN  A 202 ( 3.5A)
None
 0.69A 3mihA-3ck2A:
undetectable		 3mihA-3ck2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		3 / 3 HIS A  83
HIS A  81
HIS A 110
 None
MN  A 202 (-3.3A)
MN  A 202 ( 3.5A)
 0.72A 3mihA-3ck2A:
undetectable		 3mihA-3ck2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		3 / 3 HIS A 110
HIS A  83
HIS A  81
 MN  A 202 ( 3.5A)
None
MN  A 202 (-3.3A)
 0.41A 3mihA-3ck2A:
undetectable		 3mihA-3ck2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 7 ILE A   6
LEU A 107
ALA A 104
ALA A 103
 None
 0.85A 3r9tB-3ck2A:
undetectable		 3r9tB-3ck2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 12 GLY A  37
GLY A 109
HIS A 110
PHE A  60
SER A  12
 None
None
MN  A 202 ( 3.5A)
None
None
 1.25A 3tkaA-3ck2A:
undetectable		 3tkaA-3ck2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 12 VAL A  30
ALA A  32
PHE A 156
LEU A 157
VAL A 163
 None
None
None
None
SRT  A 301 ( 4.3A)
 1.20A 4eckA-3ck2A:
undetectable		 4eckA-3ck2A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 6 PHE A  34
LEU A 125
ASN A 126
PRO A 127
 None
 1.41A 4yv5B-3ck2A:
undetectable		 4yv5B-3ck2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 6 PHE A  34
LEU A 125
ASN A 126
PRO A 127
 None
 1.40A 4yv5A-3ck2A:
undetectable		 4yv5A-3ck2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 6 ILE A  51
VAL A  19
TRP A  48
SER A  45
 None
 0.95A 5jwaH-3ck2A:
undetectable		 5jwaH-3ck2A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 6 ASP A  38
ASP A  11
HIS A  13
HIS A 112
HIS A  81
 MN  A 202 ( 2.9A)
MN  A 201 (-3.2A)
MN  A 201 (-3.5A)
MN  A 201 (-3.4A)
MN  A 202 (-3.3A)
 1.13A 5ncdA-3ck2A:
undetectable
5ncdD-3ck2A:
undetectable		 5ncdA-3ck2A:
23.74
5ncdD-3ck2A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 6 ASP A  38
ASP A  11
HIS A  13
HIS A 112
HIS A  81
 MN  A 202 ( 2.9A)
MN  A 201 (-3.2A)
MN  A 201 (-3.5A)
MN  A 201 (-3.4A)
MN  A 202 (-3.3A)
 1.12A 5ncdB-3ck2A:
undetectable
5ncdC-3ck2A:
undetectable		 5ncdB-3ck2A:
23.74
5ncdC-3ck2A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 6 ASP A  38
ASP A  11
HIS A  13
HIS A 112
HIS A  81
 MN  A 202 ( 2.9A)
MN  A 201 (-3.2A)
MN  A 201 (-3.5A)
MN  A 201 (-3.4A)
MN  A 202 (-3.3A)
 1.10A 5nelA-3ck2A:
undetectable
5nelD-3ck2A:
undetectable		 5nelA-3ck2A:
23.74
5nelD-3ck2A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		4 / 6 ASP A  38
HIS A  13
HIS A 112
HIS A  81
 MN  A 202 ( 2.9A)
MN  A 201 (-3.5A)
MN  A 201 (-3.4A)
MN  A 202 (-3.3A)
 1.02A 5nelB-3ck2A:
undetectable
5nelC-3ck2A:
undetectable		 5nelB-3ck2A:
23.74
5nelC-3ck2A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 12 LEU A  84
VAL A  54
GLY A  37
ASP A  38
GLY A 109
 None
None
None
MN  A 202 ( 2.9A)
None
 1.20A 5nnaA-3ck2A:
undetectable		 5nnaA-3ck2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 12 LEU A  84
VAL A  54
GLY A  37
ASP A  38
GLY A 109
 None
None
None
MN  A 202 ( 2.9A)
None
 1.20A 5nnaB-3ck2A:
undetectable		 5nnaB-3ck2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 12 LEU A  84
VAL A  54
GLY A  37
ASP A  38
GLY A 109
 None
None
None
MN  A 202 ( 2.9A)
None
 1.18A 5nnaC-3ck2A:
undetectable		 5nnaC-3ck2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)
(Streptococcus
pneumoniae) 		5 / 12 LEU A  84
VAL A  54
GLY A  37
ASP A  38
GLY A 109
 None
None
None
MN  A 202 ( 2.9A)
None
 1.20A 5nnaD-3ck2A:
undetectable		 5nnaD-3ck2A:
19.25