SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ck6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.99A 2dyrN-3ck6A:
1.1
2dyrW-3ck6A:
undetectable		 2dyrN-3ck6A:
17.82
2dyrW-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		3 / 3 VAL A  54
ASP A  55
GLU A  45
 None
 0.71A 2qeuA-3ck6A:
1.7		 2qeuA-3ck6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		3 / 3 VAL A  54
ASP A  55
GLU A  45
 None
 0.70A 2qeuC-3ck6A:
undetectable		 2qeuC-3ck6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 6 HIS A  32
ARG A 119
PHE A  10
PRO A 128
 CL  A 250 (-4.3A)
None
None
None
 1.45A 2qqtA-3ck6A:
undetectable		 2qqtA-3ck6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 1.01A 3ablA-3ck6A:
undetectable
3ablJ-3ck6A:
undetectable		 3ablA-3ck6A:
17.82
3ablJ-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 8 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.92A 3ablN-3ck6A:
0.9
3ablW-3ck6A:
undetectable		 3ablN-3ck6A:
17.82
3ablW-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 6 HIS A  32
ARG A 119
PHE A  10
PRO A 128
 CL  A 250 (-4.3A)
None
None
None
 1.45A 3gclA-3ck6A:
undetectable		 3gclA-3ck6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A 223
LEU A 227
TYR A 149
ILE A 153
 None
 0.80A 3p50B-3ck6A:
3.5		 3p50B-3ck6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A 223
LEU A 227
TYR A 149
ILE A 153
 None
 0.79A 3p50C-3ck6A:
2.8		 3p50C-3ck6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A 223
LEU A 227
TYR A 149
ILE A 153
 None
 0.80A 3p50D-3ck6A:
3.5		 3p50D-3ck6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A 223
LEU A 227
TYR A 149
ILE A 153
 None
 0.80A 3p50E-3ck6A:
3.5		 3p50E-3ck6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 LEU A  76
ALA A 190
LEU A  78
ALA A 212
 None
 0.68A 4z90F-3ck6A:
5.1
4z90G-3ck6A:
5.1
4z90H-3ck6A:
5.1
4z90J-3ck6A:
3.9		 4z90F-3ck6A:
20.45
4z90G-3ck6A:
20.45
4z90H-3ck6A:
20.45
4z90J-3ck6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 LEU A  78
ALA A 212
LEU A  76
ALA A 190
 None
 0.68A 4z90F-3ck6A:
5.1
4z90G-3ck6A:
5.1
4z90H-3ck6A:
5.1
4z90J-3ck6A:
3.9		 4z90F-3ck6A:
20.45
4z90G-3ck6A:
20.45
4z90H-3ck6A:
20.45
4z90J-3ck6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.96A 5xdqN-3ck6A:
1.5
5xdqW-3ck6A:
undetectable		 5xdqN-3ck6A:
17.82
5xdqW-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.91A 5xdxA-3ck6A:
undetectable
5xdxJ-3ck6A:
undetectable		 5xdxA-3ck6A:
17.82
5xdxJ-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.94A 6nmfA-3ck6A:
1.6
6nmfJ-3ck6A:
undetectable		 6nmfA-3ck6A:
17.82
6nmfJ-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  97
LEU A  76
ARG A 108
LEU A 142
 None
None
CL  A 250 (-4.4A)
CL  A 252 (-4.7A)
 0.96A 6nmpA-3ck6A:
undetectable
6nmpJ-3ck6A:
undetectable		 6nmpA-3ck6A:
17.82
6nmpJ-3ck6A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ck6 PUTATIVE MEMBRANE
TRANSPORT PROTEIN
(Vibrio
parahaemolyticus) 		4 / 5 LEU A 232
GLN A 234
PHE A 233
PHE A 225
 None
 1.42A 6nmpP-3ck6A:
4.0
6nmpW-3ck6A:
undetectable		 6nmpP-3ck6A:
17.67
6nmpW-3ck6A:
13.64