SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ckn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 ASP A 161
ASP A 251
ALA A  27
LEU A  26
 None
 1.13A 1nh8A-3cknA:
undetectable		 1nh8A-3cknA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		5 / 12 GLY A 239
GLY A 235
GLY A 120
THR A 281
LEU A 282
 None
 1.00A 2oxtC-3cknA:
undetectable		 2oxtC-3cknA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 VAL A  52
VAL A 135
PHE A 149
ARG A  48
 None
 1.37A 3bjwH-3cknA:
undetectable		 3bjwH-3cknA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 6 ASP A  79
ARG A 131
ILE A 134
ARG A  48
 None
 1.11A 3ckzA-3cknA:
undetectable		 3ckzA-3cknA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 ASP A  68
ARG A  95
ILE A  63
VAL A 103
 None
 1.20A 3eigA-3cknA:
1.5		 3eigA-3cknA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		3 / 3 ARG A 106
LEU A  84
THR A  92
 None
 0.89A 3oxcA-3cknA:
undetectable		 3oxcA-3cknA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 8 VAL A 278
TYR A 234
LEU A 123
TYR A 218
 None
UDP  A 332 (-4.7A)
None
None
 0.89A 3v81A-3cknA:
undetectable		 3v81A-3cknA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		5 / 12 SER A 130
ASP A 133
ILE A 134
ALA A 219
VAL A 154
 None
 1.19A 4dx5B-3cknA:
undetectable		 4dx5B-3cknA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 8 VAL A 278
TYR A 234
LEU A 123
TYR A 218
 None
UDP  A 332 (-4.7A)
None
None
 0.84A 4puoC-3cknA:
undetectable		 4puoC-3cknA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 7 ARG A 261
VAL A  66
HIS A 263
GLU A  59
 None
None
MN  A 330 ( 3.7A)
UDP  A 332 (-2.4A)
 1.33A 5ad9A-3cknA:
undetectable
5ad9B-3cknA:
undetectable		 5ad9A-3cknA:
24.08
5ad9B-3cknA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 ARG A 320
GLY A 120
GLU A 121
ARG A 285
 SO4  A 331 (-3.0A)
None
None
None
 1.12A 5cdqA-3cknA:
undetectable
5cdqB-3cknA:
undetectable
5cdqC-3cknA:
undetectable		 5cdqA-3cknA:
23.05
5cdqB-3cknA:
24.32
5cdqC-3cknA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 ARG A 320
GLY A 120
GLU A 121
ARG A 285
 SO4  A 331 (-3.0A)
None
None
None
 1.14A 5cdqR-3cknA:
undetectable
5cdqS-3cknA:
undetectable
5cdqT-3cknA:
undetectable		 5cdqR-3cknA:
23.05
5cdqS-3cknA:
24.32
5cdqT-3cknA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		5 / 12 GLY A  47
GLU A  40
LEU A  41
GLU A  42
LEU A  77
 None
 1.30A 5nwvA-3cknA:
undetectable		 5nwvA-3cknA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		3 / 3 GLY A 189
VAL A 278
MET A 274
 None
None
UDP  A 332 ( 4.3A)
 0.52A 5ycpA-3cknA:
undetectable		 5ycpA-3cknA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		3 / 3 SER A 130
SER A 126
ALA A 220
 None
 0.58A 6dwnC-3cknA:
undetectable		 6dwnC-3cknA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 7 TYR A 170
GLU A 217
ASP A 139
GLU A  59
 None
None
UDP  A 332 (-3.5A)
UDP  A 332 (-2.4A)
 1.34A 6mn5B-3cknA:
undetectable		 6mn5B-3cknA:
14.48