SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 12 GLY A 170
GLY A 168
ASP A 121
ALA A 122
HIS A 163
 None
 0.87A 2gluA-3ckyA:
7.4		 2gluA-3ckyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 11 ILE A   7
ALA A  20
PHE A  65
ILE A 138
VAL A 153
 None
 1.05A 2w3aA-3ckyA:
undetectable		 2w3aA-3ckyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		4 / 4 GLY A 168
GLY A 141
GLY A 165
GLY A 170
 None
 0.52A 3bogC-3ckyA:
undetectable		 3bogC-3ckyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		4 / 4 GLY A 168
GLY A 141
GLY A 165
GLY A 170
 None
 0.53A 3bogD-3ckyA:
undetectable		 3bogD-3ckyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 11 ILE A   7
ALA A  20
PHE A  65
ILE A 138
VAL A 153
 None
 1.03A 3n0hA-3ckyA:
2.0		 3n0hA-3ckyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 11 GLY A 246
THR A 262
LEU A 179
LEU A 259
LEU A 249
 None
 1.33A 3ndvA-3ckyA:
undetectable
3ndvB-3ckyA:
undetectable		 3ndvA-3ckyA:
24.74
3ndvB-3ckyA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 11 LEU A 259
LEU A 249
GLY A 246
THR A 262
LEU A 179
 None
 1.34A 3ndvA-3ckyA:
undetectable
3ndvB-3ckyA:
undetectable		 3ndvA-3ckyA:
24.74
3ndvB-3ckyA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 11 GLY A 246
THR A 262
LEU A 179
LEU A 259
LEU A 249
 None
 1.33A 3ndvC-3ckyA:
undetectable
3ndvD-3ckyA:
undetectable		 3ndvC-3ckyA:
24.74
3ndvD-3ckyA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 11 LEU A 259
LEU A 249
GLY A 246
THR A 262
LEU A 179
 None
 1.33A 3ndvC-3ckyA:
undetectable
3ndvD-3ckyA:
undetectable		 3ndvC-3ckyA:
24.74
3ndvD-3ckyA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 12 ILE A   7
ALA A  20
PHE A  65
ILE A 138
VAL A 153
 None
 1.05A 3s3vA-3ckyA:
undetectable		 3s3vA-3ckyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 12 GLY A 168
GLY A 141
ASP A 121
SER A 104
ALA A 172
 None
 1.29A 3t7sA-3ckyA:
4.3		 3t7sA-3ckyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 12 GLY A 168
GLY A 141
ASP A 121
SER A 104
ALA A 172
 None
 1.28A 3t7sB-3ckyA:
5.6		 3t7sB-3ckyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 12 GLY A 168
GLY A 141
ASP A 121
SER A 104
ALA A 172
 None
 1.25A 3t7sD-3ckyA:
5.4		 3t7sD-3ckyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		4 / 7 ILE A 209
GLY A 214
SER A 213
SER A 212
 None
 0.85A 3v7pA-3ckyA:
undetectable		 3v7pA-3ckyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		5 / 11 ALA A 186
SER A 187
PHE A 232
ILE A 227
SER A 298
 None
 1.44A 4bb2A-3ckyA:
undetectable
4bb2B-3ckyA:
undetectable		 4bb2A-3ckyA:
20.56
4bb2B-3ckyA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		4 / 7 LEU A 200
LEU A 188
LEU A 194
ILE A 227
 None
 1.04A 4okwA-3ckyA:
undetectable		 4okwA-3ckyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		4 / 7 ASP A 239
ARG A 273
GLY A 272
GLU A 270
 None
 1.14A 5btfA-3ckyA:
undetectable
5btfC-3ckyA:
undetectable
5btfD-3ckyA:
2.5		 5btfA-3ckyA:
22.00
5btfC-3ckyA:
22.00
5btfD-3ckyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		3 / 3 SER A 213
LEU A 200
MET A 205
 None
 0.87A 5ikrB-3ckyA:
undetectable		 5ikrB-3ckyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE
(Eubacterium
barkeri) 		4 / 4 VAL A  43
LEU A  23
ASN A  39
ASP A  34
 None
 1.34A 5vcyA-3ckyA:
undetectable		 5vcyA-3ckyA:
21.45