SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ckz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.39A 1a4gA-3ckzA:
53.6		 1a4gA-3ckzA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_A_ZMRA466_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.71A 1a4gA-3ckzA:
53.6		 1a4gA-3ckzA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.48A 1a4gB-3ckzA:
53.6		 1a4gB-3ckzA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ASP A 151
ARG A 152
ILE A 222
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
None
 0.24A 1a4gB-3ckzA:
53.6		 1a4gB-3ckzA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 7 ARG A 152
ASN A 294
ARG A 371
ARG A 118
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-2.9A)
 1.44A 1f9gA-3ckzA:
undetectable		 1f9gA-3ckzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 7 ARG A 300
VAL A 290
ASN A 299
ASP A 324
 None
None
None
CA  A   1 (-3.3A)
 1.37A 1hwiC-3ckzA:
undetectable		 1hwiC-3ckzA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 7 ARG A 300
VAL A 290
ASN A 299
ASP A 324
 None
None
None
CA  A   1 (-3.3A)
 1.37A 1hwiD-3ckzA:
undetectable		 1hwiD-3ckzA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
None
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.69A 1l7fA-3ckzA:
64.4		 1l7fA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ARG A 152
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
 0.12A 1l7fA-3ckzA:
64.4		 1l7fA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ASP A 151
ARG A 152
TRP A 178
GLU A 276
ARG A 292
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
None
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
 1.45A 1l7gA-3ckzA:
64.4		 1l7gA-3ckzA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.69A 1l7gA-3ckzA:
64.4		 1l7gA-3ckzA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
None
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-4.7A)
 0.74A 1l7hA-3ckzA:
64.4		 1l7hA-3ckzA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ARG A 152
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
 0.11A 1l7hA-3ckzA:
64.4		 1l7hA-3ckzA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.42A 1nncA-3ckzA:
63.9		 1nncA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NNC_A_ZMRA479_2
(NEURAMINIDASE N9)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
None
None
 0.73A 1nncA-3ckzA:
63.9		 1nncA-3ckzA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 9 SER A  89
GLY A 285
VAL A 233
GLU A 412
ILE A 287
 None
 1.42A 1pw7B-3ckzA:
undetectable		 1pw7B-3ckzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 LEU A 426
ASP A 460
ALA A 462
GLY A 109
ILE A 108
 None
 0.98A 1t3rA-3ckzA:
undetectable		 1t3rA-3ckzA:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.44A 2cmlA-3ckzA:
64.4		 2cmlA-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.38A 2cmlA-3ckzA:
64.4		 2cmlA-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.65A 2cmlA-3ckzA:
64.4		 2cmlA-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.43A 2cmlB-3ckzA:
64.2		 2cmlB-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.36A 2cmlB-3ckzA:
64.2		 2cmlB-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.63A 2cmlB-3ckzA:
64.2		 2cmlB-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 SER A 367
SER A 370
TRP A 403
LYS A 432
 None
 0.72A 2cmlB-3ckzA:
64.2		 2cmlB-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 SER A 367
SER A 372
TRP A 403
LYS A 432
 None
 0.77A 2cmlB-3ckzA:
64.2		 2cmlB-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.43A 2cmlC-3ckzA:
64.2		 2cmlC-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.68A 2cmlC-3ckzA:
64.2		 2cmlC-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 SER A 367
SER A 370
TRP A 403
LYS A 432
 None
 1.00A 2cmlC-3ckzA:
64.2		 2cmlC-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 SER A 367
SER A 372
TRP A 403
LYS A 432
 None
 0.71A 2cmlC-3ckzA:
64.2		 2cmlC-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.43A 2cmlD-3ckzA:
64.3		 2cmlD-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.67A 2cmlD-3ckzA:
64.3		 2cmlD-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 SER A 367
SER A 370
TRP A 403
LYS A 432
 None
 0.86A 2cmlD-3ckzA:
64.3		 2cmlD-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 SER A 367
SER A 372
TRP A 403
LYS A 432
 None
 0.71A 2cmlD-3ckzA:
64.3		 2cmlD-3ckzA:
47.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.41A 2f0zA-3ckzA:
21.6		 2f0zA-3ckzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
TYR A 274
GLU A 277
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
None
ZMR  A 469 (-3.7A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 1.46A 2f0zA-3ckzA:
21.6		 2f0zA-3ckzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 156
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-3.4A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.79A 2f0zA-3ckzA:
21.6		 2f0zA-3ckzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 156
TYR A 274
GLU A 277
ARG A 371
TYR A 406
 ZMR  A 469 (-3.4A)
None
ZMR  A 469 (-3.7A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 1.36A 2f0zA-3ckzA:
21.6		 2f0zA-3ckzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.45A 2f10A-3ckzA:
8.2		 2f10A-3ckzA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 152
ARG A 156
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 347
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 ( 4.8A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.66A 2htqA-3ckzA:
67.4		 2htqA-3ckzA:
56.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTQ_A_ZMRA472_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
TRP A 178
ILE A 222
ARG A 224
 ZMR  A 469 (-3.5A)
None
None
ZMR  A 469 (-4.4A)
 0.36A 2htqA-3ckzA:
67.4		 2htqA-3ckzA:
56.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
TRP A 178
SER A 179
ILE A 222
ARG A 224
GLU A 276
ARG A 292
TYR A 347
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 ( 4.8A)
ZMR  A 469 (-4.7A)
 0.67A 2htuA-3ckzA:
68.4		 2htuA-3ckzA:
56.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HTU_A_BCZA801_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 118
ASP A 151
GLU A 227
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.9A)
 0.29A 2htuA-3ckzA:
68.4		 2htuA-3ckzA:
56.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 6 ARG A 300
GLY A 323
PRO A 326
THR A 368
 None
 1.28A 2m2oB-3ckzA:
undetectable		 2m2oB-3ckzA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 LEU A 426
ASP A 460
GLY A 461
ALA A 462
GLY A 109
ILE A 108
 None
 1.22A 2nmzB-3ckzA:
undetectable		 2nmzB-3ckzA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 LEU A 426
ASP A 460
GLY A 461
ALA A 462
GLY A 109
ILE A 108
 None
 1.19A 2q64B-3ckzA:
undetectable		 2q64B-3ckzA:
14.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.35A 3b7eA-3ckzA:
75.3		 3b7eA-3ckzA:
91.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.24A 3b7eA-3ckzA:
75.3		 3b7eA-3ckzA:
91.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_A_ZMRA1001_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.71A 3b7eA-3ckzA:
75.3		 3b7eA-3ckzA:
91.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.36A 3b7eB-3ckzA:
75.0		 3b7eB-3ckzA:
91.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.25A 3b7eB-3ckzA:
75.0		 3b7eB-3ckzA:
91.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7E_B_ZMRB1002_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.70A 3b7eB-3ckzA:
75.0		 3b7eB-3ckzA:
91.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 LEU A 426
ASP A 460
ALA A 462
GLY A 109
ILE A 108
 None
 1.16A 3el5A-3ckzA:
undetectable		 3el5A-3ckzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 GLY A 137
PRO A 169
LEU A 139
 None
 0.63A 3hcpB-3ckzA:
undetectable		 3hcpB-3ckzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 GLU A 227
GLU A 277
TRP A 423
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
None
 0.93A 3hrdA-3ckzA:
undetectable
3hrdE-3ckzA:
undetectable
3hrdF-3ckzA:
undetectable		 3hrdA-3ckzA:
18.95
3hrdE-3ckzA:
18.95
3hrdF-3ckzA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 156
TRP A 178
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.4A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.50A 3k37A-3ckzA:
53.8		 3k37A-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 156
TRP A 178
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.4A)
None
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.71A 3k37A-3ckzA:
53.8		 3k37A-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
LEU A 134
TRP A 178
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.36A 3k37A-3ckzA:
53.8		 3k37A-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		9 / 12 ARG A 118
GLU A 119
LEU A 134
TRP A 178
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.65A 3k37A-3ckzA:
53.8		 3k37A-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ASP A 151
ARG A 152
ARG A 371
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
 0.20A 3k37A-3ckzA:
53.8		 3k37A-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
GLU A 227
GLU A 277
ARG A 292
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
 0.50A 3k37B-3ckzA:
53.6		 3k37B-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
TRP A 178
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
 0.32A 3k37B-3ckzA:
53.6		 3k37B-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
GLU A 276
TYR A 406
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-4.7A)
 0.47A 3k37B-3ckzA:
53.6		 3k37B-3ckzA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.68A 3k39A-3ckzA:
52.9		 3k39A-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.73A 3k39A-3ckzA:
52.9		 3k39A-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.64A 3k39B-3ckzA:
53.0		 3k39B-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.67A 3k39C-3ckzA:
53.0		 3k39C-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.73A 3k39C-3ckzA:
53.0		 3k39C-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
 0.68A 3k39D-3ckzA:
53.0		 3k39D-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
ARG A 371
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
 0.73A 3k39D-3ckzA:
53.0		 3k39D-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.66A 3k39E-3ckzA:
53.0		 3k39E-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.72A 3k39E-3ckzA:
53.0		 3k39E-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.65A 3k39F-3ckzA:
53.0		 3k39F-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.71A 3k39F-3ckzA:
53.0		 3k39F-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.67A 3k39G-3ckzA:
53.0		 3k39G-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.72A 3k39G-3ckzA:
53.0		 3k39G-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.66A 3k39H-3ckzA:
53.0		 3k39H-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.72A 3k39H-3ckzA:
53.0		 3k39H-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.67A 3k39I-3ckzA:
52.9		 3k39I-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.73A 3k39I-3ckzA:
52.9		 3k39I-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.66A 3k39J-3ckzA:
53.0		 3k39J-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.72A 3k39J-3ckzA:
53.0		 3k39J-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.65A 3k39K-3ckzA:
52.9		 3k39K-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.72A 3k39K-3ckzA:
52.9		 3k39K-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.67A 3k39L-3ckzA:
53.0		 3k39L-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
 0.72A 3k39L-3ckzA:
53.0		 3k39L-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.66A 3k39M-3ckzA:
53.0		 3k39M-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.72A 3k39M-3ckzA:
53.0		 3k39M-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.66A 3k39N-3ckzA:
53.0		 3k39N-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.72A 3k39N-3ckzA:
53.0		 3k39N-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.66A 3k39O-3ckzA:
53.0		 3k39O-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.73A 3k39O-3ckzA:
53.0		 3k39O-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.66A 3k39P-3ckzA:
53.0		 3k39P-3ckzA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
ARG A 224
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.72A 3k39P-3ckzA:
53.0		 3k39P-3ckzA:
34.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 6 GLY A  96
MET A 376
ILE A  94
VAL A 449
 None
 1.16A 3kvvE-3ckzA:
undetectable		 3kvvE-3ckzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 10 LEU A 426
ASP A 460
GLY A 461
ALA A 462
GLY A 109
ILE A 108
 None
 1.12A 3lzvA-3ckzA:
undetectable		 3lzvA-3ckzA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 LEU A 426
ASP A 460
ALA A 462
GLY A 109
ILE A 108
 None
 0.99A 3oy4B-3ckzA:
undetectable		 3oy4B-3ckzA:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
TYR A 347
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 ( 4.8A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.36A 3sanA-3ckzA:
69.9		 3sanA-3ckzA:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.30A 3sanA-3ckzA:
69.9		 3sanA-3ckzA:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.65A 3sanA-3ckzA:
69.9		 3sanA-3ckzA:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
TYR A 347
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 ( 4.8A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.37A 3sanB-3ckzA:
69.8		 3sanB-3ckzA:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.31A 3sanB-3ckzA:
69.8		 3sanB-3ckzA:
57.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.65A 3sanB-3ckzA:
69.8		 3sanB-3ckzA:
57.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 PRO A 167
ILE A 117
SER A 440
ILE A 106
 None
 0.96A 3sfeB-3ckzA:
undetectable
3sfeC-3ckzA:
undetectable		 3sfeB-3ckzA:
20.00
3sfeC-3ckzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 6 PHE A 422
PHE A 410
ALA A  98
THR A 453
 None
 1.12A 3t3sB-3ckzA:
undetectable		 3t3sB-3ckzA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.37A 3ti5A-3ckzA:
75.0		 3ti5A-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.27A 3ti5A-3ckzA:
75.0		 3ti5A-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_A_ZMRA1002_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.72A 3ti5A-3ckzA:
75.0		 3ti5A-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.37A 3ti5B-3ckzA:
75.0		 3ti5B-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.27A 3ti5B-3ckzA:
75.0		 3ti5B-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI5_B_ZMRB1002_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.72A 3ti5B-3ckzA:
75.0		 3ti5B-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
TRP A 178
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.39A 3ticA-3ckzA:
64.0		 3ticA-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.37A 3ticA-3ckzA:
64.0		 3ticA-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
ILE A 222
ARG A 224
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
ZMR  A 469 (-4.4A)
 0.66A 3ticA-3ckzA:
64.0		 3ticA-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.40A 3ticB-3ckzA:
64.0		 3ticB-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.36A 3ticB-3ckzA:
64.0		 3ticB-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_B_ZMRB1002_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.69A 3ticB-3ckzA:
64.0		 3ticB-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.41A 3ticC-3ckzA:
64.0		 3ticC-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.37A 3ticC-3ckzA:
64.0		 3ticC-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_C_ZMRC1002_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.69A 3ticC-3ckzA:
64.0		 3ticC-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.40A 3ticD-3ckzA:
64.1		 3ticD-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.35A 3ticD-3ckzA:
64.1		 3ticD-3ckzA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ARG A 152
ARG A 156
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.65A 3ticD-3ckzA:
64.1		 3ticD-3ckzA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 7 GLY A 441
SER A 440
PHE A 466
LEU A 140
 None
 0.88A 3v7pA-3ckzA:
undetectable		 3v7pA-3ckzA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.41A 4b7nA-3ckzA:
74.2		 4b7nA-3ckzA:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.31A 4b7nA-3ckzA:
74.2		 4b7nA-3ckzA:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.83A 4b7nA-3ckzA:
74.2		 4b7nA-3ckzA:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.41A 4b7qA-3ckzA:
74.1		 4b7qA-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.26A 4b7qA-3ckzA:
74.1		 4b7qA-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.90A 4b7qA-3ckzA:
74.1		 4b7qA-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.48A 4b7qB-3ckzA:
74.1		 4b7qB-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.28A 4b7qB-3ckzA:
74.1		 4b7qB-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.31A 4b7qB-3ckzA:
74.1		 4b7qB-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_B_ZMRB601_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.73A 4b7qB-3ckzA:
74.1		 4b7qB-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.38A 4b7qC-3ckzA:
74.3		 4b7qC-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.28A 4b7qC-3ckzA:
74.3		 4b7qC-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.84A 4b7qC-3ckzA:
74.3		 4b7qC-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
SER A 246
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.40A 4b7qD-3ckzA:
74.0		 4b7qD-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 GLU A 119
SER A 246
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.31A 4b7qD-3ckzA:
74.0		 4b7qD-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4B7Q_D_ZMRD601_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.73A 4b7qD-3ckzA:
74.0		 4b7qD-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.45A 4cpnA-3ckzA:
53.7		 4cpnA-3ckzA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.08A 4cpnA-3ckzA:
53.7		 4cpnA-3ckzA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_A_ZMRA700_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.69A 4cpnA-3ckzA:
53.7		 4cpnA-3ckzA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.60A 4cpnB-3ckzA:
53.6		 4cpnB-3ckzA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.42A 4cpzA-3ckzA:
53.5		 4cpzA-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.63A 4cpzA-3ckzA:
53.4		 4cpzA-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.39A 4cpzB-3ckzA:
53.4		 4cpzB-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_B_ZMRB1471_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.73A 4cpzB-3ckzA:
53.4		 4cpzB-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.41A 4cpzC-3ckzA:
53.4		 4cpzC-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.78A 4cpzC-3ckzA:
53.4		 4cpzC-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.45A 4cpzD-3ckzA:
53.3		 4cpzD-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_D_ZMRD1471_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.74A 4cpzD-3ckzA:
53.3		 4cpzD-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.45A 4cpzE-3ckzA:
53.2		 4cpzE-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.80A 4cpzE-3ckzA:
53.2		 4cpzE-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.44A 4cpzF-3ckzA:
53.3		 4cpzF-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.80A 4cpzF-3ckzA:
53.3		 4cpzF-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.36A 4cpzG-3ckzA:
53.1		 4cpzG-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.80A 4cpzG-3ckzA:
53.1		 4cpzG-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.51A 4cpzH-3ckzA:
53.2		 4cpzH-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.79A 4cpzH-3ckzA:
53.2		 4cpzH-3ckzA:
32.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 6 GLY A  96
MET A 376
ILE A  94
VAL A 449
 None
 1.14A 4e1vF-3ckzA:
undetectable		 4e1vF-3ckzA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 152
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.30A 4i00A-3ckzA:
64.4		 4i00A-3ckzA:
46.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
ARG A 156
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.4A)
None
None
 0.71A 4i00A-3ckzA:
64.4		 4i00A-3ckzA:
46.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 134
TRP A 178
ILE A 222
ASN A 294
 None
None
None
ZMR  A 469 (-3.9A)
 0.95A 4i00A-3ckzA:
64.4		 4i00A-3ckzA:
46.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		6 / 12 LEU A 426
ASP A 460
GLY A 461
ALA A 462
GLY A 109
ILE A 108
 None
 1.18A 4jecA-3ckzA:
undetectable		 4jecA-3ckzA:
15.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ARG A 156
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.57A 4mwrA-3ckzA:
64.3		 4mwrA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 GLU A 119
GLU A 276
ARG A 292
ASN A 294
TYR A 406
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-4.7A)
 1.34A 4mwrA-3ckzA:
64.3		 4mwrA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 5 LEU A 134
ASP A 151
ARG A 152
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
None
None
 0.15A 4mwrA-3ckzA:
64.3		 4mwrA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ASP A 151
ARG A 152
ILE A 222
ARG A 224
GLU A 227
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
 1.42A 4mwvA-3ckzA:
64.2		 4mwvA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ASP A 151
ARG A 152
TRP A 178
GLU A 276
ARG A 292
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
None
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
 1.47A 4mwvA-3ckzA:
64.2		 4mwvA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		12 / 12 GLU A 119
LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.69A 4mwvA-3ckzA:
64.2		 4mwvA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
GLU A 227
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.9A)
 0.14A 4mwvA-3ckzA:
64.2		 4mwvA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.58A 4mwxA-3ckzA:
64.2		 4mwxA-3ckzA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 152
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
None
None
 0.10A 4mwxA-3ckzA:
64.2		 4mwxA-3ckzA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 GLU A 119
LEU A 134
ARG A 152
ARG A 156
TRP A 178
SER A 179
ARG A 224
GLU A 227
GLU A 276
GLU A 277
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
ZMR  A 469 ( 4.6A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-4.7A)
 0.71A 4mx0A-3ckzA:
64.1		 4mx0A-3ckzA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 ARG A 118
ASP A 151
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.9A)
 0.19A 4mx0A-3ckzA:
64.1		 4mx0A-3ckzA:
47.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 LEU A 426
ASP A 460
GLY A 461
GLY A 109
ILE A 108
 None
 0.99A 4njtB-3ckzA:
undetectable		 4njtB-3ckzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 9 LEU A 426
ASP A 460
GLY A 461
ALA A 462
ILE A 108
 None
 1.16A 4njtD-3ckzA:
undetectable		 4njtD-3ckzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 9 LEU A 426
ASP A 460
ALA A 462
GLY A 109
ILE A 108
 None
 0.99A 4q1wA-3ckzA:
undetectable		 4q1wA-3ckzA:
13.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
ASP A 151
GLU A 227
GLU A 277
ARG A 292
ASN A 294
TYR A 347
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 ( 4.8A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.54A 4wa5A-3ckzA:
67.5		 4wa5A-3ckzA:
57.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		10 / 12 ARG A 118
GLU A 119
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ASN A 294
TYR A 347
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-3.9A)
ZMR  A 469 ( 4.8A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.45A 4wa5A-3ckzA:
67.5		 4wa5A-3ckzA:
57.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.75A 4wa5A-3ckzA:
67.5		 4wa5A-3ckzA:
57.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA5_A_ZMRA501_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 ARG A 152
TRP A 178
ILE A 222
ARG A 224
 ZMR  A 469 (-3.9A)
None
None
ZMR  A 469 (-4.4A)
 0.30A 4wa5A-3ckzA:
67.5		 4wa5A-3ckzA:
57.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ILE A 117
GLY A 441
GLU A 174
SER A 123
ILE A 122
 None
 1.19A 5igwA-3ckzA:
undetectable		 5igwA-3ckzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.45A 5iqbA-3ckzA:
0.0		 5iqbA-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.44A 5iqbB-3ckzA:
0.0		 5iqbB-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.46A 5iqbC-3ckzA:
0.0		 5iqbC-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.46A 5iqbD-3ckzA:
0.0		 5iqbD-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.44A 5iqcA-3ckzA:
0.0		 5iqcA-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.47A 5iqcB-3ckzA:
0.8		 5iqcB-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.47A 5iqcC-3ckzA:
0.0		 5iqcC-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.45A 5iqcD-3ckzA:
undetectable		 5iqcD-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.47A 5iqeA-3ckzA:
0.0		 5iqeA-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.45A 5iqeD-3ckzA:
undetectable		 5iqeD-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.49A 5iqgA-3ckzA:
0.0		 5iqgA-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.50A 5iqgB-3ckzA:
0.2		 5iqgB-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.50A 5iqgC-3ckzA:
1.0		 5iqgC-3ckzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 SER A 179
ASP A 198
GLU A 119
GLU A 277
GLU A 227
 ZMR  A 469 ( 4.6A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.5A)
 1.49A 5iqgD-3ckzA:
0.1		 5iqgD-3ckzA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 156
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.60A 5l17A-3ckzA:
64.6		 5l17A-3ckzA:
47.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L17_A_ZMRA512_2
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 LEU A 134
ARG A 152
TRP A 178
ILE A 222
 None
ZMR  A 469 (-3.9A)
None
None
 0.16A 5l17A-3ckzA:
64.6		 5l17A-3ckzA:
47.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 ARG A 118
GLU A 277
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.31A 6ekuA-3ckzA:
11.7		 6ekuA-3ckzA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		11 / 12 ARG A 118
GLU A 119
ASP A 151
ARG A 152
ARG A 156
ARG A 224
GLU A 227
GLU A 276
ARG A 292
ARG A 371
TYR A 406
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-2.9A)
ZMR  A 469 (-4.7A)
 0.56A 6hcxA-3ckzA:
64.5		 6hcxA-3ckzA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3ckz NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 178
ILE A 222
GLU A 277
 None
None
ZMR  A 469 (-3.7A)
 0.07A 6hcxA-3ckzA:
64.5		 6hcxA-3ckzA:
10.90