SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		4 / 4 THR A   3
LEU A   7
VAL A  10
LEU A  14
 None
 0.73A 1fbmD-3cl3A:
undetectable		 1fbmD-3cl3A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		4 / 5 THR A   3
LEU A   7
VAL A  10
LEU A  14
 None
 0.82A 1fbmE-3cl3A:
undetectable		 1fbmE-3cl3A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		4 / 8 VAL A 148
SER A 117
VAL A 101
VAL A 134
 None
 1.25A 2y05A-3cl3A:
undetectable
2y05B-3cl3A:
undetectable		 2y05A-3cl3A:
20.12
2y05B-3cl3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		4 / 5 THR A  52
THR A  87
HIS A  83
LEU A  80
 None
 1.39A 2zj0A-3cl3A:
undetectable		 2zj0A-3cl3A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		5 / 12 VAL A  10
LEU A  25
LEU A  42
GLY A  64
LEU A  14
 None
 0.95A 3n8wA-3cl3A:
undetectable		 3n8wA-3cl3A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		5 / 12 VAL A  10
VAL A  22
LEU A  25
GLY A  64
LEU A  14
 None
 1.02A 3n8wA-3cl3A:
undetectable		 3n8wA-3cl3A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		4 / 8 LEU A   7
VAL A  22
LEU A  26
ALA A  41
 None
 0.83A 3uniB-3cl3A:
undetectable		 3uniB-3cl3A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		3 / 3 MET A 171
MET A  88
TYR A  94
 None
 1.24A 4p6xI-3cl3A:
undetectable		 4p6xI-3cl3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3cl3 ORF K13
(Human
gammaherpesvirus
8) 		4 / 6 LEU A  14
ARG A  19
VAL A  22
LEU A  23
 None
 0.95A 5x7zA-3cl3A:
undetectable		 5x7zA-3cl3A:
26.20