SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.08A 1ddrB-3cl6A:
undetectable		 1ddrB-3cl6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 0.99A 1dhfA-3cl6A:
undetectable		 1dhfA-3cl6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.09A 1dyiA-3cl6A:
undetectable		 1dyiA-3cl6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.04A 1dyiB-3cl6A:
undetectable		 1dyiB-3cl6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.14A 1jolA-3cl6A:
undetectable		 1jolA-3cl6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.12A 1tdrA-3cl6A:
undetectable		 1tdrA-3cl6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 263
PHE A  90
LEU A  89
ILE A 256
 None
 0.70A 1yc2E-3cl6A:
undetectable		 1yc2E-3cl6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		3 / 3 ARG A  41
GLN A  61
PRO A  62
 None
 0.93A 2qhfA-3cl6A:
undetectable		 2qhfA-3cl6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		4 / 7 HIS A 259
HIS A 126
TYR A 211
TYR A 189
 None
 1.29A 2vmyA-3cl6A:
undetectable
2vmyB-3cl6A:
undetectable		 2vmyA-3cl6A:
21.88
2vmyB-3cl6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 11 TYR A 244
LEU A 243
LEU A 254
LYS A 237
HIS A 282
 None
 1.22A 2x7hA-3cl6A:
undetectable
2x7hB-3cl6A:
undetectable		 2x7hA-3cl6A:
22.54
2x7hB-3cl6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		4 / 6 ASP A 132
ILE A 131
GLN A 140
GLU A 141
 None
 0.97A 2ya7C-3cl6A:
undetectable		 2ya7C-3cl6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		4 / 4 GLU A 154
GLY A 157
THR A 156
GLU A 158
 None
 1.05A 3e9xA-3cl6A:
undetectable		 3e9xA-3cl6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 272
LEU A 269
ARG A 268
PHE A 220
THR A 221
 None
 1.14A 3gwuA-3cl6A:
undetectable		 3gwuA-3cl6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A 271
ARG A 274
LEU A 258
LEU A 236
ILE A 256
 None
 1.19A 3wdmB-3cl6A:
undetectable		 3wdmB-3cl6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A 271
ARG A 274
LEU A 258
LEU A 236
ILE A 256
 None
 1.18A 3wdmD-3cl6A:
undetectable		 3wdmD-3cl6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.04A 4ej1B-3cl6A:
undetectable		 4ej1B-3cl6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 0.96A 4i13A-3cl6A:
undetectable		 4i13A-3cl6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		4 / 8 HIS A 301
ILE A 293
TRP A  21
LEU A 193
 None
 0.84A 4jq1B-3cl6A:
2.9		 4jq1B-3cl6A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 126
LEU A  54
ASN A 216
LEU A 213
GLY A 166
 None
 1.24A 4qckA-3cl6A:
undetectable		 4qckA-3cl6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.10A 4qleA-3cl6A:
undetectable		 4qleA-3cl6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 11 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.12A 4qlfA-3cl6A:
undetectable		 4qlfA-3cl6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.09A 4qlgA-3cl6A:
undetectable		 4qlgA-3cl6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.11A 4qlgB-3cl6A:
undetectable		 4qlgB-3cl6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 263
PHE A  90
LEU A  89
ILE A 256
 None
 0.70A 4rmjA-3cl6A:
undetectable		 4rmjA-3cl6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		4 / 6 CYH A 186
ASN A  34
LEU A 258
TYR A 164
 None
 1.32A 4wcxC-3cl6A:
6.9		 4wcxC-3cl6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.10A 4x5fA-3cl6A:
undetectable		 4x5fA-3cl6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.10A 4x5fB-3cl6A:
undetectable		 4x5fB-3cl6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.10A 4x5gA-3cl6A:
undetectable		 4x5gA-3cl6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.07A 4x5hA-3cl6A:
undetectable		 4x5hA-3cl6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ARG A 268
PHE A 100
TYR A 211
TYR A  35
LEU A  33
 None
 1.12A 5czyA-3cl6A:
undetectable		 5czyA-3cl6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  95
ALA A  92
PHE A  90
ILE A 263
LEU A 258
 None
 1.09A 5eajB-3cl6A:
undetectable		 5eajB-3cl6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A  86
VAL A 112
ALA A 106
GLY A 127
TYR A 211
 None
 1.06A 5igiA-3cl6A:
undetectable		 5igiA-3cl6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 259
HIS A 126
THR A 168
ALA A 106
PHE A  53
 None
 1.22A 5iwuA-3cl6A:
undetectable		 5iwuA-3cl6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		3 / 3 HIS A 301
HIS A  20
HIS A  18
 None
 0.96A 5oexA-3cl6A:
undetectable		 5oexA-3cl6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		3 / 3 GLU A  37
ARG A 261
TYR A  75
 None
 0.61A 5trqB-3cl6A:
undetectable		 5trqB-3cl6A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 276
PHE A 275
ALA A 279
ILE A  27
ALA A  28
 None
 1.01A 5vceA-3cl6A:
undetectable		 5vceA-3cl6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		3 / 3 HIS A 259
ASN A  34
LEU A  33
 None
 0.90A 6f7lB-3cl6A:
undetectable		 6f7lB-3cl6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3cl6 PUUE ALLANTOINASE
(Pseudomonas
fluorescens) 		5 / 12 TYR A 211
THR A  98
ILE A  99
PHE A  90
PHE A  31
 None
 1.27A 6j20A-3cl6A:
undetectable		 6j20A-3cl6A:
20.61