SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3clh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 VAL A 321
GLY A 320
LEU A 269
GLU A 275
 None
 0.84A 1fduD-3clhA:
undetectable		 1fduD-3clhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 LYS A 151
PRO A 150
LEU A  88
ILE A 115
SER A  98
 None
 1.42A 1lbcA-3clhA:
undetectable
1lbcC-3clhA:
undetectable		 1lbcA-3clhA:
23.89
1lbcC-3clhA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 8 SER A 206
ASN A 208
ILE A 209
GLU A 201
 None
 0.90A 1meiA-3clhA:
2.5		 1meiA-3clhA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 ILE A 254
GLY A 230
GLU A 250
PHE A 288
ASN A 260
 None
 1.13A 1sg9A-3clhA:
undetectable		 1sg9A-3clhA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ILE A 252
GLY A 249
ALA A 170
HIS A 248
 None
None
None
ZN  A 344 (-2.9A)
 0.90A 1wmqA-3clhA:
undetectable		 1wmqA-3clhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ILE A 252
GLY A 249
ALA A 170
HIS A 248
 None
None
None
ZN  A 344 (-2.9A)
 0.88A 1wmqB-3clhA:
undetectable		 1wmqB-3clhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ILE A 252
GLY A 249
ALA A 170
HIS A 248
 None
None
None
ZN  A 344 (-2.9A)
 0.89A 1wpuA-3clhA:
undetectable		 1wpuA-3clhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ILE A 252
GLY A 249
ALA A 170
HIS A 248
 None
None
None
ZN  A 344 (-2.9A)
 0.89A 1wpuB-3clhA:
undetectable		 1wpuB-3clhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ILE A 252
GLY A 249
ALA A 170
HIS A 248
 None
None
None
ZN  A 344 (-2.9A)
 0.90A 1wrqA-3clhA:
undetectable		 1wrqA-3clhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ILE A 252
GLY A 249
ALA A 170
HIS A 248
 None
None
None
ZN  A 344 (-2.9A)
 0.91A 1wrqB-3clhA:
undetectable		 1wrqB-3clhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 9 PHE A 246
GLY A 234
GLU A 174
GLU A 250
ARG A 166
 None
 1.35A 2pivA-3clhA:
undetectable		 2pivA-3clhA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 10 PHE A 288
GLY A 255
GLU A 174
GLU A 250
ARG A 166
 None
 1.34A 2piwA-3clhA:
undetectable		 2piwA-3clhA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 9 ILE A 175
ALA A 123
VAL A 125
LYS A 210
 None
NAD  A 400 ( 4.6A)
None
None
 0.96A 2vufB-3clhA:
undetectable		 2vufB-3clhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 10 VAL A 202
GLY A 171
LEU A 122
VAL A 207
ILE A 203
 None
None
NAD  A 400 (-3.7A)
None
None
 0.90A 3em3A-3clhA:
undetectable		 3em3A-3clhA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 5 LYS A 151
PRO A 150
SER A 128
LEU A  88
 None
 1.40A 3ijxH-3clhA:
undetectable		 3ijxH-3clhA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 10 LYS A 151
PRO A 150
LEU A  88
ILE A 115
SER A  98
 None
 1.37A 3iluB-3clhA:
undetectable
3iluE-3clhA:
undetectable		 3iluB-3clhA:
23.39
3iluE-3clhA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 8 ILE A  32
ILE A  31
VAL A 101
ILE A 117
 None
 0.83A 3p4wC-3clhA:
undetectable		 3p4wC-3clhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 9 ARG A 166
ALA A 173
GLY A 255
ILE A 254
LEU A 247
 None
 1.01A 3u7sB-3clhA:
undetectable		 3u7sB-3clhA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		3 / 3 HIS A 248
GLU A  63
ASN A 142
 ZN  A 344 (-2.9A)
NAD  A 400 (-2.7A)
NAD  A 400 (-3.0A)
 0.78A 4bupB-3clhA:
undetectable		 4bupB-3clhA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		3 / 3 ASP A 261
LEU A 317
VAL A 321
 None
 0.56A 4jecB-3clhA:
undetectable		 4jecB-3clhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 5 VAL A  54
LEU A  49
ILE A  31
LEU A  30
 None
 0.80A 4mghA-3clhA:
undetectable		 4mghA-3clhA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 GLY A 171
GLY A 249
ILE A 176
ILE A 175
LEU A 195
 None
 1.03A 4mwzA-3clhA:
undetectable		 4mwzA-3clhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 ALA A 123
HIS A 231
HIS A 248
GLU A 174
LEU A 160
 NAD  A 400 ( 4.6A)
None
ZN  A 344 (-2.9A)
None
None
 1.35A 4r7lA-3clhA:
undetectable		 4r7lA-3clhA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 9 PHE A 284
LEU A 286
VAL A 202
VAL A 172
LEU A 186
 None
 1.37A 4wnvA-3clhA:
undetectable		 4wnvA-3clhA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ALA A 123
GLN A 124
LEU A 122
LEU A 163
 NAD  A 400 ( 4.6A)
None
NAD  A 400 (-3.7A)
NAD  A 400 (-4.7A)
 1.07A 4xoyA-3clhA:
undetectable		 4xoyA-3clhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 6 ALA A 123
GLN A 124
LEU A 122
LEU A 163
 NAD  A 400 ( 4.6A)
None
NAD  A 400 (-3.7A)
NAD  A 400 (-4.7A)
 1.17A 4xp3A-3clhA:
undetectable		 4xp3A-3clhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		4 / 4 LEU A  30
ARG A  73
ILE A  74
ILE A  59
 None
 1.09A 5dzk2-3clhA:
undetectable
5dzkM-3clhA:
undetectable
5dzkN-3clhA:
undetectable		 5dzk2-3clhA:
4.35
5dzkM-3clhA:
22.32
5dzkN-3clhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		3 / 3 HIS A 248
GLU A  63
ASN A 142
 ZN  A 344 (-2.9A)
NAD  A 400 (-2.7A)
NAD  A 400 (-3.0A)
 0.75A 5wbvA-3clhA:
undetectable		 5wbvA-3clhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		3 / 3 HIS A 248
GLU A  63
ASN A 142
 ZN  A 344 (-2.9A)
NAD  A 400 (-2.7A)
NAD  A 400 (-3.0A)
 0.75A 5wbvB-3clhA:
undetectable		 5wbvB-3clhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 GLY A  93
ILE A  90
VAL A  56
LEU A  42
LEU A  46
 None
 0.69A 5wy0A-3clhA:
undetectable		 5wy0A-3clhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 247
GLY A 249
LEU A 199
ILE A 175
ASP A 126
 None
None
None
None
NAD  A 400 (-3.6A)
 1.23A 6bxmA-3clhA:
4.3		 6bxmA-3clhA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3clh 3-DEHYDROQUINATE
SYNTHASE
(Helicobacter
pylori) 		5 / 8 GLY A 130
VAL A  15
GLY A  95
SER A  98
ALA A  91
 None
None
NAD  A 400 (-3.2A)
None
None
 1.38A 6hu9H-3clhA:
undetectable
6hu9e-3clhA:
undetectable		 6hu9H-3clhA:
14.33
6hu9e-3clhA:
15.92