SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3clk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 12 LEU A 254
ALA A 244
GLY A 182
ALA A 257
ILE A 253
 None
 0.86A 1rl8B-3clkA:
undetectable		 1rl8B-3clkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		4 / 7 ARG A 196
ASP A 187
PHE A  75
GLN A 291
 GOL  A 500 (-2.5A)
None
GOL  A 500 (-4.5A)
GOL  A 500 (-4.5A)
 1.19A 2jc9A-3clkA:
undetectable		 2jc9A-3clkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		4 / 7 ILE A 122
ILE A  79
LEU A  80
ILE A  83
 None
 0.90A 2q83A-3clkA:
undetectable		 2q83A-3clkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 ARG A 194
GLY A 193
SER A 159
 None
 0.64A 2xctB-3clkA:
undetectable		 2xctB-3clkA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 10 LEU A 254
ALA A 244
GLY A 182
ALA A 257
ILE A 253
 None
 0.92A 3ekpB-3clkA:
undetectable		 3ekpB-3clkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 10 LEU A 254
ALA A 244
GLY A 182
ALA A 257
ILE A 253
 None
 1.00A 3ekpC-3clkA:
undetectable		 3ekpC-3clkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		4 / 7 GLY A 252
GLY A 185
MET A 278
CYH A 279
 None
 0.95A 3ko0M-3clkA:
0.0
3ko0P-3clkA:
undetectable		 3ko0M-3clkA:
17.44
3ko0P-3clkA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 SER A 288
ASP A 247
ASN A  74
 None
 0.99A 3lsfB-3clkA:
undetectable
3lsfE-3clkA:
2.7		 3lsfB-3clkA:
22.87
3lsfE-3clkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 ASP A 247
ASN A  74
SER A 288
 None
 0.97A 3lsfB-3clkA:
undetectable
3lsfE-3clkA:
2.7		 3lsfB-3clkA:
22.87
3lsfE-3clkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 ASP A 247
ASN A  74
SER A 288
 None
 0.82A 3lslA-3clkA:
undetectable
3lslD-3clkA:
undetectable		 3lslA-3clkA:
23.17
3lslD-3clkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 SER A 288
ASP A 247
ASN A  74
 None
 0.83A 3lslA-3clkA:
1.4
3lslD-3clkA:
undetectable		 3lslA-3clkA:
23.17
3lslD-3clkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 PHE A 293
SER A 160
SER A 148
 None
 1.01A 3ufgB-3clkA:
undetectable		 3ufgB-3clkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		4 / 8 VAL A 323
ILE A 165
SER A 288
ALA A 244
 None
 0.99A 4eyzA-3clkA:
undetectable		 4eyzA-3clkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		4 / 8 VAL A 323
ILE A 165
SER A 288
ALA A 244
 None
 1.00A 4eyzB-3clkA:
undetectable		 4eyzB-3clkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 9 ALA A  76
ILE A  83
GLY A 297
ILE A 127
VAL A  68
 None
 1.04A 4nptA-3clkA:
undetectable		 4nptA-3clkA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		4 / 5 GLY A 185
LEU A 239
ILE A 216
LEU A 286
 None
 0.84A 4o8fA-3clkA:
undetectable		 4o8fA-3clkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 12 ALA A 184
GLY A 185
ILE A 216
GLY A 182
PHE A 233
 None
 1.04A 4obwA-3clkA:
2.9		 4obwA-3clkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		6 / 12 ALA A 184
GLY A 185
GLY A 219
ILE A 216
GLY A 182
PHE A 233
 None
 1.24A 4obwB-3clkA:
3.1		 4obwB-3clkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 12 ALA A 184
GLY A 185
ILE A 216
GLY A 182
PHE A 233
 None
 1.06A 4obwD-3clkA:
undetectable		 4obwD-3clkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 12 ALA A 210
ILE A 211
ILE A 174
ASN A 171
GLY A 199
 None
 1.00A 4r3aB-3clkA:
undetectable		 4r3aB-3clkA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 11 THR A 282
SER A 330
ASP A 274
THR A 276
GLY A 275
 None
None
GOL  A 500 (-2.8A)
None
None
 1.13A 4zjoD-3clkA:
undetectable		 4zjoD-3clkA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		5 / 12 LEU A 124
GLY A 150
ASP A 274
PHE A  75
VAL A  68
 None
None
GOL  A 500 (-2.8A)
GOL  A 500 (-4.5A)
None
 1.47A 5d0yA-3clkA:
undetectable		 5d0yA-3clkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 LEU A 239
GLN A 180
LYS A 217
 None
 0.74A 6exiB-3clkA:
2.3		 6exiB-3clkA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3clk TRANSCRIPTION
REGULATOR
(Lactobacillus
plantarum) 		3 / 3 LEU A 239
GLN A 180
LYS A 217
 None
 0.75A 6exiA-3clkA:
2.4		 6exiA-3clkA:
15.55