SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3clm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 324
LEU A 327
ARG A 204
ALA A 208
LEU A 209
 None
EDO  A 358 ( 4.4A)
SO4  A 353 ( 3.9A)
None
None
 0.91A 1fk6A-3clmA:
undetectable		 1fk6A-3clmA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  19
LEU A  23
VAL A  24
SER A  26
VAL A 104
 None
 1.39A 1ie9A-3clmA:
undetectable		 1ie9A-3clmA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 314
LEU A 225
PHE A 200
THR A 170
ALA A 328
 None
 1.20A 1n5xA-3clmA:
undetectable		 1n5xA-3clmA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 314
LEU A 225
PHE A 200
THR A 170
ALA A 328
 None
 1.20A 1n5xB-3clmA:
undetectable		 1n5xB-3clmA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		4 / 7 THR A 119
LEU A 161
VAL A 139
ASP A 147
 None
 0.86A 2cppA-3clmA:
undetectable		 2cppA-3clmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  46
THR A 289
ILE A 202
ASN A 283
THR A 284
 None
None
None
None
EDO  A 354 ( 4.9A)
 1.04A 2rlcA-3clmA:
undetectable		 2rlcA-3clmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 10 PHE A 237
TYR A 236
ALA A 198
LEU A 149
VAL A 159
 None
 1.42A 2wuzB-3clmA:
undetectable		 2wuzB-3clmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		4 / 7 GLU A  76
ARG A 125
GLU A 122
SER A 109
 EDO  A 360 (-4.8A)
None
None
None
 1.12A 2zt7A-3clmA:
undetectable		 2zt7A-3clmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		3 / 3 GLU A 122
LEU A 112
LEU A 163
 None
 0.47A 3ohtA-3clmA:
undetectable		 3ohtA-3clmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		3 / 3 GLU A 122
LEU A 112
LEU A 163
 None
 0.48A 3ohtB-3clmA:
undetectable		 3ohtB-3clmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		4 / 7 ASN A  43
GLN A  48
PHE A  47
ASN A  18
 CL  A 352 ( 4.4A)
None
None
None
 1.41A 4kcnB-3clmA:
1.5		 4kcnB-3clmA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		4 / 8 THR A 119
LEU A 161
VAL A 139
ASP A 147
 None
 0.83A 4l4aA-3clmA:
undetectable		 4l4aA-3clmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 THR A  41
THR A 162
ALA A 258
ARG A 204
PHE A 201
 None
CL  A 352 (-3.4A)
EDO  A 354 (-3.5A)
SO4  A 353 ( 3.9A)
EDO  A 354 ( 4.3A)
 1.06A 4pbhA-3clmA:
undetectable		 4pbhA-3clmA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 11 LEU A 164
ALA A 198
THR A  41
ILE A  46
ASP A  17
 None
None
None
None
EDO  A 354 (-2.8A)
 1.24A 4uuuB-3clmA:
undetectable		 4uuuB-3clmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 273
VAL A   7
LEU A   4
ILE A   3
GLY A   0
 None
 1.05A 4y8wA-3clmA:
undetectable		 4y8wA-3clmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 273
VAL A   7
LEU A   4
ILE A   3
GLY A   0
 None
 1.09A 4y8wB-3clmA:
undetectable		 4y8wB-3clmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		3 / 3 LEU A  10
VAL A 273
ASP A 274
 None
 0.43A 4y8wC-3clmA:
undetectable		 4y8wC-3clmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		3 / 3 PRO A  44
ILE A 202
SER A 109
 None
 0.73A 5fsaA-3clmA:
undetectable		 5fsaA-3clmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		3 / 3 THR A 142
ASP A 143
ALA A 144
 None
 0.00A 5g5gB-3clmA:
undetectable		 5g5gB-3clmA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3clm TRANSALDOLASE
(Neisseria
gonorrhoeae) 		4 / 6 PHE A  47
PRO A  44
THR A  41
ILE A  46
 None
 1.39A 5ih0A-3clmA:
undetectable		 5ih0A-3clmA:
24.15