SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3clo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  47
ALA A  45
PHE A  33
GLN A  29
THR A  58
 None
 1.17A 1dhfB-3cloA:
undetectable		 1dhfB-3cloA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  47
ALA A  45
PHE A  33
GLN A  29
THR A  58
 None
 1.25A 2w3mB-3cloA:
undetectable		 2w3mB-3cloA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A 193
LEU A 256
ALA A 250
PRO A  92
 None
 1.17A 3gv1A-3cloA:
undetectable
3gv1C-3cloA:
undetectable		 3gv1A-3cloA:
18.32
3gv1C-3cloA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 256
ALA A 250
PRO A  92
HIS A 193
 None
 1.18A 3gv1A-3cloA:
undetectable
3gv1B-3cloA:
undetectable		 3gv1A-3cloA:
18.32
3gv1B-3cloA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.45A 3o5rA-3cloA:
undetectable		 3o5rA-3cloA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 152
PRO A 149
LEU A  22
ASP A  49
 None
 1.23A 3oi8A-3cloA:
undetectable		 3oi8A-3cloA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.35A 3vawA-3cloA:
undetectable		 3vawA-3cloA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.35A 4dz2A-3cloA:
undetectable
4dz2B-3cloA:
undetectable		 4dz2A-3cloA:
19.83
4dz2B-3cloA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.37A 4dz2A-3cloA:
undetectable
4dz2B-3cloA:
undetectable		 4dz2A-3cloA:
19.83
4dz2B-3cloA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.36A 4dz3A-3cloA:
undetectable		 4dz3A-3cloA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.37A 4dz3B-3cloA:
undetectable		 4dz3B-3cloA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.35A 4laxA-3cloA:
undetectable		 4laxA-3cloA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.39A 4qt2A-3cloA:
undetectable		 4qt2A-3cloA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 257
GLU A 201
LYS A 202
LEU A 205
 None
 0.74A 4wg0L-3cloA:
undetectable
4wg0M-3cloA:
undetectable		 4wg0L-3cloA:
3.88
4wg0M-3cloA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 205
ARG A 206
ARG A 209
 None
 0.95A 4yiaB-3cloA:
undetectable		 4yiaB-3cloA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A  86
ILE A  90
ARG A  99
TYR A 160
 None
 1.44A 4zzcC-3cloA:
0.0		 4zzcC-3cloA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A  86
ILE A  90
ARG A  99
TYR A 160
 None
 1.47A 4zzcD-3cloA:
0.0		 4zzcD-3cloA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.35A 5hwcA-3cloA:
undetectable		 5hwcA-3cloA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		4 / 5 MET A 128
TYR A 160
GLY A  43
GLY A  42
 None
 1.21A 5x7pA-3cloA:
undetectable		 5x7pA-3cloA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 3clo TRANSCRIPTIONAL
REGULATOR
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A  82
PHE A 106
VAL A 142
TYR A 160
ILE A  86
 None
 1.34A 6mkeD-3cloA:
undetectable		 6mkeD-3cloA:
13.89