SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 8 PHE A 108
ILE A  36
PHE A  34
PHE A  16
 None
 0.85A 1fslA-3cm5A:
undetectable		 1fslA-3cm5A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 TRP A 225
ARG A 226
ASP A 287
TYR A 298
 None
 1.11A 1kf6M-3cm5A:
undetectable
1kf6N-3cm5A:
undetectable		 1kf6M-3cm5A:
18.09
1kf6N-3cm5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 ILE A 289
GLU A 285
ARG A 226
ASP A 287
 None
 0.94A 1mt1B-3cm5A:
undetectable
1mt1C-3cm5A:
undetectable		 1mt1B-3cm5A:
15.21
1mt1C-3cm5A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 7 ASN A  61
TYR A  27
ASN A  24
HIS A 290
 None
 1.14A 1wu8A-3cm5A:
undetectable
1wu8C-3cm5A:
undetectable		 1wu8A-3cm5A:
21.74
1wu8C-3cm5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		5 / 12 PHE A 135
LEU A 116
ALA A 120
VAL A  31
LEU A  96
 None
 1.13A 2g78A-3cm5A:
undetectable		 2g78A-3cm5A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		3 / 3 ARG A 151
GLY A 153
PRO A 154
 None
 0.60A 2hreD-3cm5A:
undetectable		 2hreD-3cm5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		3 / 3 ASP A 111
THR A 209
GLU A 206
 None
 0.84A 2zifB-3cm5A:
undetectable		 2zifB-3cm5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 5 PHE A 106
PHE A 108
LEU A  14
PHE A  34
 None
 1.36A 3abmC-3cm5A:
undetectable
3abmJ-3cm5A:
undetectable		 3abmC-3cm5A:
20.55
3abmJ-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 5 PHE A 106
PHE A 108
LEU A  14
PHE A  34
 None
 1.36A 3abmP-3cm5A:
undetectable
3abmW-3cm5A:
undetectable		 3abmP-3cm5A:
20.55
3abmW-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		5 / 12 ILE A 188
PHE A 108
PHE A 135
LEU A 116
PHE A  34
 None
 1.26A 3apwB-3cm5A:
undetectable		 3apwB-3cm5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 5 ASP A 111
ASP A  15
ASP A 115
ARG A 118
 None
MN  A 300 (-2.5A)
None
None
 1.41A 3naiC-3cm5A:
undetectable		 3naiC-3cm5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		5 / 10 PHE A 108
VAL A  31
PHE A  85
TYR A  89
PHE A  34
 None
 1.27A 3r6wA-3cm5A:
0.0
3r6wB-3cm5A:
0.0		 3r6wA-3cm5A:
21.73
3r6wB-3cm5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		5 / 10 VAL A  31
PHE A  85
TYR A  89
PHE A  34
PHE A 108
 None
 1.30A 3r6wA-3cm5A:
undetectable
3r6wB-3cm5A:
undetectable		 3r6wA-3cm5A:
21.73
3r6wB-3cm5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		3 / 3 TYR A 297
MET A 267
LEU A 208
 None
 0.91A 3vw1D-3cm5A:
undetectable		 3vw1D-3cm5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 8 VAL A  37
ILE A  13
ASP A  15
PHE A  16
 None
None
MN  A 300 (-2.5A)
None
 0.65A 3wzeA-3cm5A:
undetectable		 3wzeA-3cm5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 5 GLY A 233
TYR A 221
GLU A 237
ASP A 231
 None
 1.29A 4xueA-3cm5A:
undetectable		 4xueA-3cm5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		5 / 12 ALA A 120
LEU A  14
VAL A  31
LEU A  99
LEU A  96
 None
 0.97A 5x23A-3cm5A:
undetectable		 5x23A-3cm5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.06A 5z84P-3cm5A:
undetectable
5z84W-3cm5A:
undetectable		 5z84P-3cm5A:
20.55
5z84W-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.12A 5z85P-3cm5A:
undetectable
5z85W-3cm5A:
undetectable		 5z85P-3cm5A:
20.55
5z85W-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.01A 5z86C-3cm5A:
undetectable
5z86J-3cm5A:
undetectable		 5z86C-3cm5A:
20.55
5z86J-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.04A 5z86P-3cm5A:
undetectable
5z86W-3cm5A:
undetectable		 5z86P-3cm5A:
20.55
5z86W-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.07A 5zcoP-3cm5A:
undetectable
5zcoW-3cm5A:
undetectable		 5zcoP-3cm5A:
20.55
5zcoW-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.05A 5zcpC-3cm5A:
undetectable
5zcpJ-3cm5A:
undetectable		 5zcpC-3cm5A:
20.55
5zcpJ-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cm5 CELL DEATH-RELATED
NUCLEASE 4
(Caenorhabditis
elegans) 		4 / 6 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.07A 5zcpP-3cm5A:
undetectable
5zcpW-3cm5A:
undetectable		 5zcpP-3cm5A:
20.55
5zcpW-3cm5A:
13.31