SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		3 / 3 ALA A  84
VAL A 103
TRP A 105
 None
 0.90A 1micA-3cmbA:
undetectable
1micB-3cmbA:
undetectable		 1micA-3cmbA:
4.56
1micB-3cmbA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		4 / 5 ALA A  99
ALA A  63
ALA A  33
GLN A 201
 None
None
None
P33  A 269 (-3.4A)
 0.88A 2nyrB-3cmbA:
undetectable		 2nyrB-3cmbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		4 / 8 SER A 159
LEU A  34
ALA A 246
LEU A 248
 None
 0.77A 4iklA-3cmbA:
undetectable
4iklB-3cmbA:
undetectable		 4iklA-3cmbA:
19.15
4iklB-3cmbA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		3 / 3 GLU A  54
ARG A  88
HIS A  90
 None
 0.81A 4kf9A-3cmbA:
undetectable		 4kf9A-3cmbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		4 / 7 VAL A 103
TRP A 105
ILE A  81
LEU A 238
 None
 1.12A 4xo7B-3cmbA:
undetectable		 4xo7B-3cmbA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		4 / 6 GLU A 106
TYR A  78
GLY A  76
GLY A  75
 None
 0.96A 5x7pB-3cmbA:
undetectable		 5x7pB-3cmbA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		4 / 5 VAL A 197
PRO A 200
GLY A 259
TYR A 199
 None
None
None
P33  A 269 (-3.8A)
 1.34A 5x80A-3cmbA:
undetectable
5x80B-3cmbA:
undetectable		 5x80A-3cmbA:
23.05
5x80B-3cmbA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		4 / 5 PRO A 200
GLY A 259
TYR A 199
VAL A 197
 None
None
P33  A 269 (-3.8A)
None
 1.35A 5x80C-3cmbA:
undetectable
5x80D-3cmbA:
undetectable		 5x80C-3cmbA:
23.05
5x80D-3cmbA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 3cmb ACETOACETATE
DECARBOXYLASE
(Methanoculleus
marisnigri) 		5 / 12 GLY A 114
THR A   9
GLY A  19
GLY A  18
MET A 258
 P33  A 269 ( 4.5A)
None
None
None
None
 1.02A 6brdB-3cmbA:
undetectable		 6brdB-3cmbA:
16.43