SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 397
TYR A 353
GLY A 158
GLU A 350
 None
 1.02A 1jlfA-3cmmA:
undetectable
1jlfB-3cmmA:
undetectable		 1jlfA-3cmmA:
18.88
1jlfB-3cmmA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 527
PHE A 528
VAL A 440
SER A 495
 None
 1.08A 1kb9A-3cmmA:
undetectable
1kb9C-3cmmA:
undetectable
1kb9D-3cmmA:
undetectable
1kb9E-3cmmA:
undetectable		 1kb9A-3cmmA:
18.39
1kb9C-3cmmA:
17.01
1kb9D-3cmmA:
12.62
1kb9E-3cmmA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A 870
PHE A 483
LEU A 439
VAL A 468
ALA A 498
 None
 1.35A 1q23A-3cmmA:
undetectable
1q23B-3cmmA:
undetectable		 1q23A-3cmmA:
11.75
1q23B-3cmmA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 153
PHE A 296
PHE A 366
LEU A 879
 None
 1.09A 1qcaA-3cmmA:
undetectable		 1qcaA-3cmmA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 573
GLU A 565
GLN A 576
PHE A 898
VAL A 899
 None
 1.28A 1qu3A-3cmmA:
undetectable		 1qu3A-3cmmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 708
ASN A 694
LEU A 691
PHE A 605
 None
 1.47A 1ru9H-3cmmA:
undetectable
1ru9L-3cmmA:
undetectable		 1ru9H-3cmmA:
13.11
1ru9L-3cmmA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  70
ASP A  67
ASP A  75
 None
 0.73A 1sqfA-3cmmA:
5.0		 1sqfA-3cmmA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 474
SER A  17
LEU A 479
ASN A 478
 None
 1.10A 1y0xX-3cmmA:
undetectable		 1y0xX-3cmmA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 559
PRO A 580
THR A1000
THR A1021
 None
 1.28A 1ymxB-3cmmA:
undetectable		 1ymxB-3cmmA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 326
ILE A 348
LEU A 322
LEU A 299
TYR A 390
 None
 1.08A 2a15A-3cmmA:
undetectable		 2a15A-3cmmA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.20A 2eimJ-3cmmA:
undetectable		 2eimJ-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.23A 2eimW-3cmmA:
undetectable		 2eimW-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 4 SER A 664
TRP A 675
ASP A 763
ILE A 762
 None
 1.35A 2oxtD-3cmmA:
3.6		 2oxtD-3cmmA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.12A 3ag1J-3cmmA:
undetectable		 3ag1J-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.22A 3ag2J-3cmmA:
undetectable		 3ag2J-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.20A 3ag4J-3cmmA:
undetectable		 3ag4J-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 6 VAL A  55
GLN A  22
GLY A 570
ARG A  21
 None
 1.04A 3bjwE-3cmmA:
undetectable		 3bjwE-3cmmA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 157
ASP A  75
GLN A  72
GLU A  69
 None
 1.28A 3dh0A-3cmmA:
5.3		 3dh0A-3cmmA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 866
THR A 869
THR A 870
SER A 871
 None
 1.10A 3snfA-3cmmA:
undetectable		 3snfA-3cmmA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 972
LYS A 973
PRO A 970
 None
 1.20A 4dv1L-3cmmA:
undetectable		 4dv1L-3cmmA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 321
ARG A 305
HIS A 306
 None
 0.87A 4kf9A-3cmmA:
undetectable		 4kf9A-3cmmA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 159
GLY A 158
GLN A 354
ARG A 405
THR A  78
 None
 1.34A 4olmA-3cmmA:
undetectable		 4olmA-3cmmA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 540
GLU A 448
LEU A 458
VAL A 502
ILE A 513
 None
 1.28A 4r38C-3cmmA:
undetectable		 4r38C-3cmmA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 540
GLU A 448
ASN A 452
LEU A 458
VAL A 502
 None
 1.35A 4r3aB-3cmmA:
undetectable		 4r3aB-3cmmA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 456
PHE A 424
GLY A 357
ALA A 355
LEU A 394
 None
 1.22A 4retA-3cmmA:
4.0		 4retA-3cmmA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 867
THR A 870
LYS A  53
GLY A 367
ALA A 371
 None
 1.28A 5l66K-3cmmA:
undetectable
5l66L-3cmmA:
undetectable		 5l66K-3cmmA:
12.35
5l66L-3cmmA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 867
THR A 870
LYS A  53
GLY A 367
ALA A 371
 None
 1.28A 5l66Y-3cmmA:
undetectable
5l66Z-3cmmA:
undetectable		 5l66Y-3cmmA:
12.35
5l66Z-3cmmA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 347
ILE A 348
ASP A 316
LEU A 394
LEU A 397
 None
None
PRO  A5119 (-3.7A)
None
None
 1.02A 5nfjB-3cmmA:
2.5		 5nfjB-3cmmA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 347
ILE A 348
ASP A 316
LEU A 394
LEU A 397
 None
None
PRO  A5119 (-3.7A)
None
None
 1.02A 5nfjC-3cmmA:
2.9		 5nfjC-3cmmA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 735
VAL A 731
PHE A 669
ILE A 762
 None
 0.98A 5of1A-3cmmA:
undetectable		 5of1A-3cmmA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 735
VAL A 731
PHE A 669
ILE A 762
 None
 0.99A 5of1B-3cmmA:
undetectable		 5of1B-3cmmA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 286
ASP A 282
LEU A 903
 None
 0.71A 5uhbC-3cmmA:
undetectable		 5uhbC-3cmmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 286
ASP A 282
LEU A 903
 None
 0.65A 5uhcC-3cmmA:
undetectable		 5uhcC-3cmmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 6 THR A 835
ASN A 839
ILE A 609
GLU A 848
 None
 1.22A 5uigA-3cmmA:
undetectable		 5uigA-3cmmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 423
LEU A 351
ASN A 419
ASP A 358
 None
 1.36A 5vcyA-3cmmA:
undetectable		 5vcyA-3cmmA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.17A 5w97J-3cmmA:
undetectable		 5w97J-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.15A 5wauJ-3cmmA:
undetectable		 5wauJ-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.07A 5x19J-3cmmA:
undetectable		 5x19J-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.09A 5x1bJ-3cmmA:
undetectable		 5x1bJ-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.12A 5x1bW-3cmmA:
undetectable		 5x1bW-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.12A 5x1fW-3cmmA:
undetectable		 5x1fW-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 456
GLU A  50
THR A 568
SER A 566
GLY A 573
 None
 1.27A 5xipA-3cmmA:
2.4		 5xipA-3cmmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.22A 5z86J-3cmmA:
undetectable		 5z86J-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 395
ARG A 288
ALA A 284
LYS A 285
 None
 1.17A 6an0A-3cmmA:
undetectable		 6an0A-3cmmA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 876
GLY A 875
VAL A 423
ILE A 359
ASP A 358
 None
 1.33A 6bxnB-3cmmA:
3.3		 6bxnB-3cmmA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 439
VAL A 437
PHE A 538
THR A 540
LEU A 458
 None
 1.15A 6h1lB-3cmmA:
undetectable		 6h1lB-3cmmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 890
ILE A 579
PRO A 580
LEU A 582
 None
 1.22A 6mkeB-3cmmA:
undetectable		 6mkeB-3cmmA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 890
ILE A 579
PRO A 580
LEU A 582
 None
 1.32A 6mkeA-3cmmA:
undetectable		 6mkeA-3cmmA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  46
LYS A  45
ASN A 419
GLY A 158
 None
 0.86A 6n7fA-3cmmA:
6.4		 6n7fA-3cmmA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.16A 6nknJ-3cmmA:
undetectable		 6nknJ-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 959
MET A1001
THR A1000
LEU A1024
 None
 1.19A 6nknW-3cmmA:
undetectable		 6nknW-3cmmA:
5.08