SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 12 GLY A 154
THR A 337
VAL A 333
LEU A 336
LEU A 109
 None
 1.09A 1mx1C-3cmnA:
undetectable		 1mx1C-3cmnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 4 ILE A 293
LEU A 292
VAL A 353
ALA A 359
 None
 0.86A 1mz9A-3cmnA:
undetectable		 1mz9A-3cmnA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 5 ILE A 293
LEU A 292
VAL A 353
ALA A 359
 None
 0.75A 1mz9C-3cmnA:
undetectable		 1mz9C-3cmnA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 5 ARG A  67
ILE A 189
PRO A 187
GLU A 186
 None
 1.48A 1oniG-3cmnA:
undetectable
1oniH-3cmnA:
undetectable		 1oniG-3cmnA:
17.38
1oniH-3cmnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 189
MET A  77
TYR A  74
PHE A 203
GLU A 186
 None
 1.30A 1p5zB-3cmnA:
undetectable		 1p5zB-3cmnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P62_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 189
MET A  77
TYR A  74
PHE A 203
GLU A 186
 None
 1.32A 1p62B-3cmnA:
0.0		 1p62B-3cmnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 5 PHE A 120
PHE A 116
TRP A  46
GLY A 155
 None
 1.35A 2qmzA-3cmnA:
undetectable
2qmzB-3cmnA:
undetectable		 2qmzA-3cmnA:
19.07
2qmzB-3cmnA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 189
MET A  77
TYR A  74
PHE A 203
GLU A 186
 None
 1.35A 2vppA-3cmnA:
undetectable		 2vppA-3cmnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 189
MET A  77
TYR A  74
PHE A 203
GLU A 186
 None
 1.38A 2vppB-3cmnA:
undetectable		 2vppB-3cmnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 189
MET A  77
TYR A  74
PHE A 203
GLU A 186
 None
 1.43A 2zi9B-3cmnA:
0.0		 2zi9B-3cmnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 7 GLN A 118
PHE A 120
LEU A 232
PHE A 228
 None
 1.00A 2zxwC-3cmnA:
undetectable
2zxwJ-3cmnA:
undetectable		 2zxwC-3cmnA:
21.80
2zxwJ-3cmnA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 6 GLN A 118
PHE A 120
LEU A 232
PHE A 228
 None
 1.02A 2zxwP-3cmnA:
undetectable
2zxwW-3cmnA:
undetectable		 2zxwP-3cmnA:
21.80
2zxwW-3cmnA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 5 GLN A 118
PHE A 120
LEU A 232
PHE A 228
 None
 0.99A 3ablC-3cmnA:
1.9
3ablJ-3cmnA:
undetectable		 3ablC-3cmnA:
21.80
3ablJ-3cmnA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 6 ILE A 293
ILE A 315
TRP A 206
MET A 301
 None
 1.24A 3welA-3cmnA:
undetectable		 3welA-3cmnA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 11 ASN A 188
ALA A  62
GLN A 195
PHE A 203
ILE A 207
 None
 1.35A 4j4vA-3cmnA:
0.4		 4j4vA-3cmnA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 11 ASN A 188
ALA A  62
GLN A 195
PHE A 203
ILE A 207
 None
 1.30A 4j4vD-3cmnA:
0.4
4j4vE-3cmnA:
undetectable		 4j4vD-3cmnA:
23.63
4j4vE-3cmnA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		3 / 3 HIS A 299
GLY A 361
ILE A 362
 None
 0.64A 4k50I-3cmnA:
undetectable		 4k50I-3cmnA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 6 TYR A 168
GLY A 180
SER A 181
LEU A 182
 None
 1.25A 5bphA-3cmnA:
undetectable		 5bphA-3cmnA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 4 TYR A 168
GLY A 180
SER A 181
LEU A 182
 None
 1.23A 5bphC-3cmnA:
undetectable		 5bphC-3cmnA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 6 TYR A 168
GLY A 180
SER A 181
LEU A 182
 None
 1.22A 5bphD-3cmnA:
undetectable		 5bphD-3cmnA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		5 / 12 LEU A 375
LEU A 343
LEU A 341
PHE A 228
LEU A 172
 None
 0.94A 5iepA-3cmnA:
undetectable		 5iepA-3cmnA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 8 VAL A 185
GLN A 162
GLY A 158
LEU A 157
 None
 0.93A 5w3jB-3cmnA:
undetectable		 5w3jB-3cmnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 8 GLU A 107
VAL A 185
ARG A  50
GLN A  51
 None
 1.13A 6fbvD-3cmnA:
2.7		 6fbvD-3cmnA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3cmn PUTATIVE HYDROLASE
(Chloroflexus
aurantiacus) 		4 / 5 ASN A 298
TYR A 168
GLY A 166
HIS A 214
 None
 1.26A 6gh9A-3cmnA:
undetectable		 6gh9A-3cmnA:
11.15