SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cmt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 GLU A1096
ALA A2179
LEU A2178
LEU A2215
GLU A1068
 ALF  A1501 ( 3.1A)
None
None
None
None
 1.46A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 GLU A2096
ALA A3179
LEU A3178
LEU A3215
GLU A2068
 ALF  A2501 ( 3.3A)
None
None
None
None
 1.46A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 GLU A3096
ALA A4179
LEU A4178
LEU A4215
GLU A3068
 ALF  A3501 ( 3.2A)
None
None
None
None
 1.44A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 8 LEU A2215
LEU A2149
GLY A2122
ILE A1159
MET A2175
 None
 1.48A 1n13A-3cmtA:
undetectable
1n13F-3cmtA:
undetectable		 1n13A-3cmtA:
2.86
1n13F-3cmtA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 8 LEU A3215
LEU A3149
GLY A3122
ILE A2159
MET A3175
 None
 1.50A 1n13A-3cmtA:
undetectable
1n13F-3cmtA:
undetectable		 1n13A-3cmtA:
2.86
1n13F-3cmtA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 8 LEU A4215
LEU A4149
GLY A4122
ILE A3159
MET A4175
 None
 1.47A 1n13A-3cmtA:
undetectable
1n13F-3cmtA:
undetectable		 1n13A-3cmtA:
2.86
1n13F-3cmtA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A  99
ALA A  98
GLU A  96
LEU A 107
ILE A 102
 None
None
ALF  A 501 ( 3.2A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A1099
ALA A1098
GLU A1096
LEU A1107
ILE A1102
 None
None
ALF  A1501 ( 3.1A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A2099
ALA A2098
GLU A2096
LEU A2107
ILE A2102
 None
None
ALF  A2501 ( 3.3A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A3099
ALA A3098
GLU A3096
LEU A3107
ILE A3102
 None
None
ALF  A3501 ( 3.2A)
None
None
 0.95A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A4099
ALA A4098
GLU A4096
LEU A4107
ILE A4102
 None
None
ALF  A4501 ( 3.3A)
None
None
 0.94A 1s9pD-3cmtA:
undetectable		 1s9pD-3cmtA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A1143
LEU A1166
ALA A1167
ALA A1174
ALA A1214
 None
 1.14A 1sa1A-3cmtA:
undetectable
1sa1B-3cmtA:
undetectable		 1sa1A-3cmtA:
14.81
1sa1B-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A2143
LEU A2166
ALA A2167
ALA A2174
ALA A2214
 None
 1.15A 1sa1A-3cmtA:
undetectable
1sa1B-3cmtA:
undetectable		 1sa1A-3cmtA:
14.81
1sa1B-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A3143
LEU A3166
ALA A3167
ALA A3174
ALA A3214
 None
 1.15A 1sa1A-3cmtA:
undetectable
1sa1B-3cmtA:
undetectable		 1sa1A-3cmtA:
14.81
1sa1B-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A1143
LEU A1166
ALA A1167
ALA A1174
ALA A1214
 None
 1.15A 1sa1C-3cmtA:
undetectable
1sa1D-3cmtA:
undetectable		 1sa1C-3cmtA:
14.81
1sa1D-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A2143
LEU A2166
ALA A2167
ALA A2174
ALA A2214
 None
 1.16A 1sa1C-3cmtA:
undetectable
1sa1D-3cmtA:
undetectable		 1sa1C-3cmtA:
14.81
1sa1D-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A3143
LEU A3166
ALA A3167
ALA A3174
ALA A3214
 None
 1.15A 1sa1C-3cmtA:
undetectable
1sa1D-3cmtA:
undetectable		 1sa1C-3cmtA:
14.81
1sa1D-3cmtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ALA A1081
ARG A1085
LEU A1107
ILE A1262
PHE A1092
 None
 1.26A 1xzxX-3cmtA:
undetectable		 1xzxX-3cmtA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 ARG A2324
LEU A2075
LEU A2056
LEU A2051
 None
 0.93A 2bfpC-3cmtA:
undetectable		 2bfpC-3cmtA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 ARG A3324
LEU A3075
LEU A3056
LEU A3051
 None
 0.98A 2bfpC-3cmtA:
undetectable		 2bfpC-3cmtA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 PHE A3191
PRO A3057
ILE A3192
VAL A3143
LEU A3215
 None
 1.22A 2zzmA-3cmtA:
undetectable		 2zzmA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ARG A 222
PHE A 191
PRO A  57
ILE A 192
VAL A 143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ARG A1222
PHE A1191
PRO A1057
ILE A1192
VAL A1143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ARG A3222
PHE A3191
PRO A3057
ILE A3192
VAL A3143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ARG A4222
PHE A4191
PRO A4057
ILE A4192
VAL A4143
 None
 1.31A 2zznA-3cmtA:
undetectable		 2zznA-3cmtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A 180
ASP A 139
ILE A 190
LEU A  56
ASN A 186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A1180
ASP A1139
ILE A1190
LEU A1056
ASN A1186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A2180
ASP A2139
ILE A2190
LEU A2056
ASN A2186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A3180
ASP A3139
ILE A3190
LEU A3056
ASN A3186
 None
 1.18A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A4180
ASP A4139
ILE A4190
LEU A4056
ASN A4186
 None
 1.17A 3eeoA-3cmtA:
1.7		 3eeoA-3cmtA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A1143
ILE A1128
ALA A1125
GLU A1127
ALA A1174
 None
 0.90A 3mdvB-3cmtA:
undetectable		 3mdvB-3cmtA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A2143
ILE A2128
ALA A2125
GLU A2127
ALA A2174
 None
 0.91A 3mdvB-3cmtA:
undetectable		 3mdvB-3cmtA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 VAL A4143
ILE A4128
ALA A4125
GLU A4127
ALA A4174
 None
 0.90A 3mdvB-3cmtA:
undetectable		 3mdvB-3cmtA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 11 ALA A  50
ALA A 258
VAL A 246
ALA A  53
GLY A  54
 None
 0.97A 3mg0K-3cmtA:
undetectable
3mg0L-3cmtA:
undetectable		 3mg0K-3cmtA:
8.62
3mg0L-3cmtA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A1052
ASP A 100
ILE A1251
GLY A1054
ASN A1332
 None
ADP  A 502 (-4.4A)
None
None
None
 1.18A 3ps9A-3cmtA:
3.2		 3ps9A-3cmtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A2052
ASP A1100
ILE A2251
GLY A2054
ASN A2332
 None
ADP  A1502 ( 4.7A)
None
None
None
 1.19A 3ps9A-3cmtA:
3.2		 3ps9A-3cmtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 GLY A3052
ASP A2100
ILE A3251
GLY A3054
ASN A3332
 None
ADP  A2502 (-4.6A)
None
None
None
 1.16A 3ps9A-3cmtA:
3.2		 3ps9A-3cmtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 9 PHE A3260
ASN A3269
ILE A3268
GLY A3267
THR A3074
 None
None
None
None
ADP  A3502 (-3.7A)
 1.17A 3t3rB-3cmtA:
undetectable		 3t3rB-3cmtA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 VAL A  62
LEU A 223
ILE A  64
VAL A  79
 None
 0.98A 4a9kB-3cmtA:
undetectable		 4a9kB-3cmtA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 VAL A1062
LEU A1223
ILE A1064
VAL A1079
 None
 0.97A 4a9kB-3cmtA:
undetectable		 4a9kB-3cmtA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 VAL A2062
LEU A2223
ILE A2064
VAL A2079
 None
 0.98A 4a9kB-3cmtA:
undetectable		 4a9kB-3cmtA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 VAL A3062
LEU A3223
ILE A3064
VAL A3079
 None
 0.98A 4a9kB-3cmtA:
undetectable		 4a9kB-3cmtA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 VAL A4062
LEU A4223
ILE A4064
VAL A4079
 None
 0.98A 4a9kB-3cmtA:
undetectable		 4a9kB-3cmtA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 ILE A  64
ASP A  48
GLY A  43
SER A  44
PHE A 260
 None
 1.12A 4bwlC-3cmtA:
undetectable		 4bwlC-3cmtA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 ILE A1064
ASP A1048
GLY A1043
SER A1044
PHE A1260
 None
 1.13A 4bwlC-3cmtA:
undetectable		 4bwlC-3cmtA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 10 ILE A2064
ASP A2048
GLY A2043
SER A2044
PHE A2260
 None
 1.13A 4bwlC-3cmtA:
undetectable		 4bwlC-3cmtA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
None
ADP  A 502 (-3.3A)
None
 0.89A 4ze3A-3cmtA:
undetectable		 4ze3A-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 TYR A1065
ILE A1192
GLY A1071
THR A1242
 None
None
ADP  A1502 (-3.4A)
None
 0.90A 4ze3A-3cmtA:
undetectable		 4ze3A-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 TYR A2065
ILE A2192
GLY A2071
THR A2242
 None
None
ADP  A2502 (-3.4A)
None
 0.90A 4ze3A-3cmtA:
undetectable		 4ze3A-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 TYR A3065
ILE A3192
GLY A3071
THR A3242
 None
None
ADP  A3502 (-3.4A)
None
 0.89A 4ze3A-3cmtA:
undetectable		 4ze3A-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 TYR A4065
ILE A4192
GLY A4071
THR A4242
 None
None
ADP  A4502 (-3.2A)
None
 0.90A 4ze3A-3cmtA:
undetectable		 4ze3A-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 VAL A 143
ILE A 128
ALA A 125
ALA A 174
 None
 0.70A 4zf8A-3cmtA:
undetectable		 4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 VAL A1143
ILE A1128
ALA A1125
ALA A1174
 None
 0.70A 4zf8A-3cmtA:
undetectable		 4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 VAL A2143
ILE A2128
ALA A2125
ALA A2174
 None
 0.69A 4zf8A-3cmtA:
undetectable		 4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 VAL A3143
ILE A3128
ALA A3125
ALA A3174
 None
 0.70A 4zf8A-3cmtA:
undetectable		 4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 VAL A4143
ILE A4128
ALA A4125
ALA A4174
 None
 0.69A 4zf8A-3cmtA:
undetectable		 4zf8A-3cmtA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 11 THR A  74
ALA A  81
GLY A 108
ALA A 104
ASP A 100
 ADP  A 502 (-4.0A)
None
None
None
ADP  A 502 (-4.4A)
 1.34A 5bxnV-3cmtA:
undetectable
5bxnW-3cmtA:
undetectable		 5bxnV-3cmtA:
9.61
5bxnW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 11 THR A1074
ALA A1081
GLY A1108
ALA A1104
ASP A1100
 ADP  A1502 (-3.9A)
None
None
None
ADP  A1502 ( 4.7A)
 1.34A 5bxnV-3cmtA:
undetectable
5bxnW-3cmtA:
undetectable		 5bxnV-3cmtA:
9.61
5bxnW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 11 THR A2074
ALA A2081
GLY A2108
ALA A2104
ASP A2100
 ADP  A2502 (-3.8A)
None
None
None
ADP  A2502 (-4.6A)
 1.34A 5bxnV-3cmtA:
undetectable
5bxnW-3cmtA:
undetectable		 5bxnV-3cmtA:
9.61
5bxnW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 11 THR A3074
ALA A3081
GLY A3108
ALA A3104
ASP A3100
 ADP  A3502 (-3.7A)
None
None
None
ADP  A3502 ( 4.8A)
 1.34A 5bxnV-3cmtA:
undetectable
5bxnW-3cmtA:
undetectable		 5bxnV-3cmtA:
9.61
5bxnW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 11 THR A4074
ALA A4081
GLY A4108
ALA A4104
ASP A4100
 ADP  A4502 (-3.8A)
None
None
None
ADP  A4502 ( 4.9A)
 1.34A 5bxnV-3cmtA:
undetectable
5bxnW-3cmtA:
undetectable		 5bxnV-3cmtA:
9.61
5bxnW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
None
ADP  A 502 (-3.3A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A1065
ILE A1192
GLY A1071
THR A1242
 None
None
ADP  A1502 (-3.4A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A2065
ILE A2192
GLY A2071
THR A2242
 None
None
ADP  A2502 (-3.4A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A3065
ILE A3192
GLY A3071
THR A3242
 None
None
ADP  A3502 (-3.4A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A4065
ILE A4192
GLY A4071
THR A4242
 None
None
ADP  A4502 (-3.2A)
None
 0.92A 5esfA-3cmtA:
undetectable		 5esfA-3cmtA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
None
ADP  A 502 (-3.3A)
None
 0.89A 5esjA-3cmtA:
undetectable		 5esjA-3cmtA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A1065
ILE A1192
GLY A1071
THR A1242
 None
None
ADP  A1502 (-3.4A)
None
 0.90A 5esjA-3cmtA:
undetectable		 5esjA-3cmtA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A2065
ILE A2192
GLY A2071
THR A2242
 None
None
ADP  A2502 (-3.4A)
None
 0.90A 5esjA-3cmtA:
undetectable		 5esjA-3cmtA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A3065
ILE A3192
GLY A3071
THR A3242
 None
None
ADP  A3502 (-3.4A)
None
 0.90A 5esjA-3cmtA:
undetectable		 5esjA-3cmtA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 TYR A4065
ILE A4192
GLY A4071
THR A4242
 None
None
ADP  A4502 (-3.2A)
None
 0.90A 5esjA-3cmtA:
undetectable		 5esjA-3cmtA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ILE A  49
ALA A  50
SER A  41
GLY A  54
VAL A 323
 None
 1.21A 5i75A-3cmtA:
undetectable		 5i75A-3cmtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ILE A4049
ALA A4050
SER A4041
GLY A4054
VAL A4323
 None
 1.20A 5i75A-3cmtA:
undetectable		 5i75A-3cmtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A  74
ALA A  81
GLY A 108
ALA A 104
ASP A 100
 ADP  A 502 (-4.0A)
None
None
None
ADP  A 502 (-4.4A)
 1.37A 5l5zH-3cmtA:
undetectable
5l5zI-3cmtA:
undetectable		 5l5zH-3cmtA:
9.61
5l5zI-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A1074
ALA A1081
GLY A1108
ALA A1104
ASP A1100
 ADP  A1502 (-3.9A)
None
None
None
ADP  A1502 ( 4.7A)
 1.37A 5l5zH-3cmtA:
undetectable
5l5zI-3cmtA:
undetectable		 5l5zH-3cmtA:
9.61
5l5zI-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A2074
ALA A2081
GLY A2108
ALA A2104
ASP A2100
 ADP  A2502 (-3.8A)
None
None
None
ADP  A2502 (-4.6A)
 1.37A 5l5zH-3cmtA:
undetectable
5l5zI-3cmtA:
undetectable		 5l5zH-3cmtA:
9.61
5l5zI-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A3074
ALA A3081
GLY A3108
ALA A3104
ASP A3100
 ADP  A3502 (-3.7A)
None
None
None
ADP  A3502 ( 4.8A)
 1.37A 5l5zH-3cmtA:
undetectable
5l5zI-3cmtA:
undetectable		 5l5zH-3cmtA:
9.61
5l5zI-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A4074
ALA A4081
GLY A4108
ALA A4104
ASP A4100
 ADP  A4502 (-3.8A)
None
None
None
ADP  A4502 ( 4.9A)
 1.37A 5l5zH-3cmtA:
undetectable
5l5zI-3cmtA:
undetectable		 5l5zH-3cmtA:
9.61
5l5zI-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A  74
ALA A  81
GLY A 108
ALA A 104
ASP A 100
 ADP  A 502 (-4.0A)
None
None
None
ADP  A 502 (-4.4A)
 1.37A 5l5zV-3cmtA:
undetectable
5l5zW-3cmtA:
undetectable		 5l5zV-3cmtA:
9.61
5l5zW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A1074
ALA A1081
GLY A1108
ALA A1104
ASP A1100
 ADP  A1502 (-3.9A)
None
None
None
ADP  A1502 ( 4.7A)
 1.38A 5l5zV-3cmtA:
undetectable
5l5zW-3cmtA:
undetectable		 5l5zV-3cmtA:
9.61
5l5zW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A2074
ALA A2081
GLY A2108
ALA A2104
ASP A2100
 ADP  A2502 (-3.8A)
None
None
None
ADP  A2502 (-4.6A)
 1.38A 5l5zV-3cmtA:
undetectable
5l5zW-3cmtA:
undetectable		 5l5zV-3cmtA:
9.61
5l5zW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A3074
ALA A3081
GLY A3108
ALA A3104
ASP A3100
 ADP  A3502 (-3.7A)
None
None
None
ADP  A3502 ( 4.8A)
 1.37A 5l5zV-3cmtA:
undetectable
5l5zW-3cmtA:
undetectable		 5l5zV-3cmtA:
9.61
5l5zW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 THR A4074
ALA A4081
GLY A4108
ALA A4104
ASP A4100
 ADP  A4502 (-3.8A)
None
None
None
ADP  A4502 ( 4.9A)
 1.38A 5l5zV-3cmtA:
undetectable
5l5zW-3cmtA:
undetectable		 5l5zV-3cmtA:
9.61
5l5zW-3cmtA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 ASN A1249
PHE A1255
THR A  74
GLY A  71
 None
None
ADP  A 502 (-4.0A)
ADP  A 502 (-3.3A)
 0.94A 5nzxA-3cmtA:
2.6		 5nzxA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 ASN A2249
PHE A2255
THR A1074
GLY A1071
 None
None
ADP  A1502 (-3.9A)
ADP  A1502 (-3.4A)
 0.95A 5nzxA-3cmtA:
2.6		 5nzxA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 ASN A3249
PHE A3255
THR A2074
GLY A2071
 None
None
ADP  A2502 (-3.8A)
ADP  A2502 (-3.4A)
 0.94A 5nzxA-3cmtA:
2.6		 5nzxA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 8 ASN A4249
PHE A4255
THR A3074
GLY A3071
 None
None
ADP  A3502 (-3.7A)
ADP  A3502 (-3.4A)
 0.95A 5nzxA-3cmtA:
2.6		 5nzxA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 ASN A1249
PHE A1255
THR A  74
GLY A  71
 None
None
ADP  A 502 (-4.0A)
ADP  A 502 (-3.3A)
 0.90A 5nzyA-3cmtA:
2.5		 5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 ASN A2249
PHE A2255
THR A1074
GLY A1071
 None
None
ADP  A1502 (-3.9A)
ADP  A1502 (-3.4A)
 0.90A 5nzyA-3cmtA:
2.5		 5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 ASN A3249
PHE A3255
THR A2074
GLY A2071
 None
None
ADP  A2502 (-3.8A)
ADP  A2502 (-3.4A)
 0.90A 5nzyA-3cmtA:
2.5		 5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 7 ASN A4249
PHE A4255
THR A3074
GLY A3071
 None
None
ADP  A3502 (-3.7A)
ADP  A3502 (-3.4A)
 0.90A 5nzyA-3cmtA:
2.5		 5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A 185
VAL A 138
ALA A1009
ALA A 137
GLY A 136
 None
 1.19A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A1185
VAL A1138
ALA A2009
ALA A1137
GLY A1136
 None
 1.21A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A2185
VAL A2138
ALA A3009
ALA A2137
GLY A2136
 None
 1.21A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A3185
VAL A3138
ALA A4009
ALA A3137
GLY A3136
 None
 1.19A 5tzoB-3cmtA:
undetectable		 5tzoB-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A 185
VAL A 138
ALA A1009
ALA A 137
GLY A 136
 None
 1.32A 5tzoC-3cmtA:
undetectable		 5tzoC-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A1185
VAL A1138
ALA A2009
ALA A1137
GLY A1136
 None
 1.34A 5tzoC-3cmtA:
undetectable		 5tzoC-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A2185
VAL A2138
ALA A3009
ALA A2137
GLY A2136
 None
 1.35A 5tzoC-3cmtA:
undetectable		 5tzoC-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 SER A3185
VAL A3138
ALA A4009
ALA A3137
GLY A3136
 None
 1.32A 5tzoC-3cmtA:
undetectable		 5tzoC-3cmtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 ILE A2128
ILE A3017
LEU A3014
THR A2089
VAL A2138
 None
 0.99A 5uvmB-3cmtA:
undetectable		 5uvmB-3cmtA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A1126
PHE A1191
ILE A1093
ALA A1091
GLY A1059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A2126
PHE A2191
ILE A2093
ALA A2091
GLY A2059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A3126
PHE A3191
ILE A3093
ALA A3091
GLY A3059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3cmt PROTEIN RECA
(Escherichia
coli) 		5 / 12 LEU A4126
PHE A4191
ILE A4093
ALA A4091
GLY A4059
 None
 1.04A 5veuA-3cmtA:
undetectable		 5veuA-3cmtA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A1250
LEU A  77
ASP A 144
 ALF  A 501 ( 3.0A)
None
MG  A 500 (-2.9A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A2250
LEU A1077
ASP A1144
 ALF  A1501 ( 2.7A)
None
MG  A1500 (-3.2A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A3250
LEU A2077
ASP A2144
 ALF  A2501 ( 2.9A)
None
MG  A2500 (-3.2A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 LYS A4250
LEU A3077
ASP A3144
 ALF  A3501 ( 2.8A)
None
MG  A3500 (-3.3A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 GLU A 320
LYS A 322
GLU A 318
ALA A 316
 None
 0.97A 6an0A-3cmtA:
2.5		 6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 GLU A1320
LYS A1322
GLU A1318
ALA A1316
 None
 0.97A 6an0A-3cmtA:
2.5		 6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 GLU A2320
LYS A2322
GLU A2318
ALA A2316
 None
 0.98A 6an0A-3cmtA:
2.5		 6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 GLU A3320
LYS A3322
GLU A3318
ALA A3316
 None
 0.97A 6an0A-3cmtA:
2.5		 6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 6 GLU A4320
LYS A4322
GLU A4318
ALA A4316
 None
 0.97A 6an0A-3cmtA:
2.5		 6an0A-3cmtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 ILE A1093
SER A1117
ALA A1131
LEU A1178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 ILE A2093
SER A2117
ALA A2131
LEU A2178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 ILE A3093
SER A3117
ALA A3131
LEU A3178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3cmt PROTEIN RECA
(Escherichia
coli) 		4 / 5 ILE A4093
SER A4117
ALA A4131
LEU A4178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3cmt PROTEIN RECA
(Escherichia
coli) 		3 / 3 PHE A4270
ARG A4324
ALA A4082
 None
 0.93A 6ecfB-3cmtA:
undetectable		 6ecfB-3cmtA:
11.03