SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A  60
LEU A  93
ALA A 112
VAL A  96
LEU A  70
 None
None
ZN  A 301 (-4.1A)
None
None
 1.20A 1kt7A-3cneA:
undetectable		 1kt7A-3cneA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A  92
GLY A  62
VAL A  56
ILE A  57
 None
 0.94A 2aoiA-3cneA:
undetectable		 2aoiA-3cneA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.99A 2ejfA-3cneA:
undetectable		 2ejfA-3cneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 138
ALA A 129
PHE A 154
ILE A  97
THR A 144
 None
 1.16A 2w3aA-3cneA:
undetectable		 2w3aA-3cneA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.95A 2zgwA-3cneA:
undetectable		 2zgwA-3cneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.91A 2zgwB-3cneA:
undetectable		 2zgwB-3cneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 117
ILE A  97
ALA A 112
VAL A  10
 None
None
ZN  A 301 (-4.1A)
None
 0.75A 3me6B-3cneA:
undetectable		 3me6B-3cneA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 8 GLN A  20
LYS A 147
ASN A 161
THR A 162
TRP A 164
 None
 0.68A 4d1yA-3cneA:
35.9
4d1yB-3cneA:
35.5		 4d1yA-3cneA:
87.50
4d1yB-3cneA:
87.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 125
GLY A 141
THR A 156
ASP A 151
ILE A 150
 None
 0.87A 5njvC-3cneA:
2.0		 5njvC-3cneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 131
GLU A 160
ASN A  46
 None
 1.01A 5wbvA-3cneA:
undetectable		 5wbvA-3cneA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 131
GLU A 160
ASN A  46
 None
 1.01A 5wbvB-3cneA:
undetectable		 5wbvB-3cneA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3cne PUTATIVE PROTEASE I
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 125
GLY A 141
THR A 156
ASP A 151
ILE A 150
 None
 1.00A 5wz1A-3cneA:
2.2		 5wz1A-3cneA:
19.50