SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 10 VAL A  27
PHE A  38
LEU A  60
TYR A  59
LEU A  49
 None
 1.49A 1j78B-3cnhA:
0.0		 1j78B-3cnhA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLU A 109
ASP A  20
ASP A 165
GLY A  11
PHE A 121
 PO4  A 201 ( 4.6A)
None
NA  A 200 (-2.9A)
PO4  A 201 ( 3.5A)
None
 1.40A 1q8jA-3cnhA:
2.4		 1q8jA-3cnhA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		3 / 3 GLU A  40
LEU A  44
LEU A  60
 None
 0.73A 3ohtA-3cnhA:
undetectable		 3ohtA-3cnhA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 10 ALA A 144
LEU A 106
LEU A 150
ALA A 153
VAL A 163
 None
 1.02A 3r9cA-3cnhA:
undetectable		 3r9cA-3cnhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		3 / 4 SER A 133
GLY A  18
GLU A  22
 None
 0.67A 3raeA-3cnhA:
undetectable
3raeC-3cnhA:
2.6		 3raeA-3cnhA:
17.75
3raeC-3cnhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A  15
GLY A  11
ASN A 107
PHE A 126
LEU A   6
 None
PO4  A 201 ( 3.5A)
PO4  A 201 (-4.5A)
None
None
 0.99A 3vywC-3cnhA:
undetectable		 3vywC-3cnhA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLU A 109
ASN A 169
GLY A  11
ASN A  17
GLN A  23
 PO4  A 201 ( 4.6A)
None
PO4  A 201 ( 3.5A)
None
None
 1.43A 4djeB-3cnhA:
undetectable		 4djeB-3cnhA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A  49
GLY A  18
LEU A  15
ASN A 108
LEU A 113
 None
None
None
PO4  A 201 (-4.5A)
None
 1.15A 4x61A-3cnhA:
undetectable		 4x61A-3cnhA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 8 TRP A  19
ALA A  46
LEU A  49
GLY A 110
 None
 0.80A 4xk8a-3cnhA:
undetectable		 4xk8a-3cnhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 4 LEU A  91
LEU A 123
GLY A 122
GLU A 125
 None
 1.09A 5hhjA-3cnhA:
undetectable		 5hhjA-3cnhA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		3 / 3 GLU A 158
HIS A 179
ARG A 174
 None
 0.98A 5uunA-3cnhA:
undetectable		 5uunA-3cnhA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 5 ASN A 169
ASP A   9
ASN A  17
ARG A  24
 None
NA  A 200 ( 2.5A)
None
None
 1.36A 5vooB-3cnhA:
undetectable		 5vooB-3cnhA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 8 ARG A 190
VAL A 181
ARG A 100
GLN A  99
 None
 1.28A 6fbvD-3cnhA:
undetectable		 6fbvD-3cnhA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3cnh HYDROLASE FAMILY
PROTEIN
(Deinococcus
radiodurans) 		4 / 6 MET A  80
TRP A  19
ALA A  46
LEU A  49
 None
 1.15A 6fosB-3cnhA:
undetectable		 6fosB-3cnhA:
18.27