SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cnj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 8 LEU A 416
ALA A 360
LEU A  80
LEU A 432
 None
 0.88A 1dvtA-3cnjA:
undetectable
1dvtB-3cnjA:
undetectable		 1dvtA-3cnjA:
13.67
1dvtB-3cnjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 7 VAL A 358
SER A 357
ASN A 353
ASP A 355
 None
 1.29A 1hwiC-3cnjA:
2.3		 1hwiC-3cnjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 7 VAL A 358
SER A 357
ASN A 353
ASP A 355
 None
 1.29A 1hwiD-3cnjA:
0.0		 1hwiD-3cnjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 TYR A  20
GLY A 114
VAL A  95
ALA A  23
SER A 227
 FAD  A 510 (-4.5A)
FAD  A 510 (-3.0A)
None
None
None
 1.07A 1kiaA-3cnjA:
3.0		 1kiaA-3cnjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 TYR A  20
GLY A 114
VAL A  95
ALA A  23
SER A 227
 FAD  A 510 (-4.5A)
FAD  A 510 (-3.0A)
None
None
None
 1.06A 1kiaD-3cnjA:
2.6		 1kiaD-3cnjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 TYR A  20
GLY A 114
VAL A  95
ALA A  23
SER A 227
 FAD  A 510 (-4.5A)
FAD  A 510 (-3.0A)
None
None
None
 1.10A 1nbhA-3cnjA:
2.7		 1nbhA-3cnjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 TYR A  20
GLY A 114
VAL A  95
ALA A  23
SER A 227
 FAD  A 510 (-4.5A)
FAD  A 510 (-3.0A)
None
None
None
 1.10A 1nbhC-3cnjA:
undetectable		 1nbhC-3cnjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 TYR A  20
GLY A 114
VAL A  95
ALA A  23
SER A 227
 FAD  A 510 (-4.5A)
FAD  A 510 (-3.0A)
None
None
None
 1.08A 1nbhD-3cnjA:
2.5		 1nbhD-3cnjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 7 GLN A 180
ALA A 423
ARG A 178
GLU A 179
 SO4  A 511 (-4.3A)
None
None
SO4  A 511 (-2.5A)
 1.16A 1t9wA-3cnjA:
undetectable		 1t9wA-3cnjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 7 ARG A 385
ASN A 406
PRO A 408
ALA A 409
 None
 1.29A 2ejgB-3cnjA:
undetectable		 2ejgB-3cnjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 5 ASP A 474
SER A 476
LEU A 292
GLY A 293
 FAD  A 510 (-4.4A)
None
None
FAD  A 510 ( 4.0A)
 1.13A 2j2pA-3cnjA:
undetectable
2j2pB-3cnjA:
undetectable		 2j2pA-3cnjA:
19.88
2j2pB-3cnjA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		6 / 12 VAL A  15
GLY A  21
ALA A  23
SER A  25
LEU A  27
LEU A  29
 None
FAD  A 510 (-4.2A)
None
None
None
None
 1.16A 3hs6A-3cnjA:
undetectable		 3hs6A-3cnjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 ASN A 221
SER A 211
ARG A  64
ARG A  87
VAL A  85
 None
 1.44A 3jb3A-3cnjA:
undetectable		 3jb3A-3cnjA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 5 GLY A 114
GLY A 115
ASN A 119
GLU A  40
 FAD  A 510 (-3.0A)
FAD  A 510 (-3.4A)
FAD  A 510 (-3.9A)
FAD  A 510 (-2.7A)
 1.27A 4fglC-3cnjA:
2.2		 4fglC-3cnjA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 ALA A 212
SER A 341
ALA A 123
MET A 122
GLY A 121
 None
None
None
FAD  A 510 (-4.0A)
FAD  A 510 (-4.0A)
 1.19A 4r29B-3cnjA:
undetectable		 4r29B-3cnjA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 ALA A 212
SER A 341
ALA A 123
MET A 122
GLY A 121
 None
None
None
FAD  A 510 (-4.0A)
FAD  A 510 (-4.0A)
 1.28A 4r29C-3cnjA:
undetectable		 4r29C-3cnjA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 LEU A 375
ALA A 327
THR A 380
ALA A 360
ALA A 363
 None
 1.26A 4x1iB-3cnjA:
undetectable		 4x1iB-3cnjA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 GLY A 290
GLY A 475
GLY A 450
ALA A  22
GLU A  40
 FAD  A 510 (-3.5A)
FAD  A 510 (-3.6A)
None
None
FAD  A 510 (-2.7A)
 0.97A 5c0oG-3cnjA:
2.7		 5c0oG-3cnjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 5 GLY A 315
PRO A 448
THR A 295
THR A 387
 None
 1.14A 5h5fA-3cnjA:
1.9		 5h5fA-3cnjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 8 LEU A 292
LEU A 449
TYR A 446
MET A 104
 None
None
FAD  A 510 (-3.6A)
None
 1.18A 5hbsA-3cnjA:
undetectable		 5hbsA-3cnjA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 GLY A 114
ILE A 244
ALA A  22
GLY A  21
ALA A  23
 FAD  A 510 (-3.0A)
None
None
FAD  A 510 (-4.2A)
None
 0.93A 5kb6B-3cnjA:
2.4		 5kb6B-3cnjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 6 PHE A 487
THR A 491
ASP A 474
GLY A 475
 FAD  A 510 (-3.8A)
None
FAD  A 510 (-4.4A)
FAD  A 510 (-3.6A)
 1.02A 5mraA-3cnjA:
undetectable
5mraB-3cnjA:
undetectable		 5mraA-3cnjA:
16.93
5mraB-3cnjA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 8 VAL A 138
LEU A 493
THR A 489
ALA A 492
 None
 0.92A 5tt3H-3cnjA:
undetectable		 5tt3H-3cnjA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 8 THR A  18
GLY A  19
ALA A  23
GLY A 114
 None
FAD  A 510 (-3.4A)
None
FAD  A 510 (-3.0A)
 0.63A 5vw9A-3cnjA:
3.4		 5vw9A-3cnjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		5 / 12 ALA A 441
VAL A 482
VAL A 124
LEU A 375
ALA A 363
 None
 1.09A 6djzC-3cnjA:
undetectable		 6djzC-3cnjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 7 VAL A 299
LEU A 287
GLY A 293
GLY A 317
 None
None
FAD  A 510 ( 4.0A)
None
 0.74A 6eu9D-3cnjA:
undetectable		 6eu9D-3cnjA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 4 ASP A 474
ILE A 478
PRO A 479
LEU A 477
 FAD  A 510 (-4.4A)
None
None
None
 1.38A 6mkeB-3cnjA:
undetectable		 6mkeB-3cnjA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3cnj CHOLESTEROL OXIDASE
(Streptomyces
sp.
SA-COO) 		4 / 4 ASP A 474
ILE A 478
PRO A 479
LEU A 477
 FAD  A 510 (-4.4A)
None
None
None
 1.34A 6mkeA-3cnjA:
undetectable		 6mkeA-3cnjA:
11.72