SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3co8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 7 SER A  29
ALA A 205
SER A 218
ALA A 220
 None
 0.98A 1k5qA-3co8A:
undetectable
1k5qB-3co8A:
undetectable		 1k5qA-3co8A:
19.73
1k5qB-3co8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 5 PHE A 164
ASN A 134
ILE A 136
ASP A 130
 None
 0.99A 1yc2D-3co8A:
undetectable		 1yc2D-3co8A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 7 PHE A 164
ASN A 134
ILE A 136
ASP A 130
 None
 0.94A 1yc2E-3co8A:
undetectable		 1yc2E-3co8A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 6 LEU A 346
LEU A 343
LEU A 248
LEU A 298
 None
 0.87A 2ab2A-3co8A:
undetectable		 2ab2A-3co8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 7 SER A 159
ASP A 161
LEU A 127
GLU A 147
 None
 0.93A 2cdqB-3co8A:
undetectable		 2cdqB-3co8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 PHE A  81
LEU A 102
VAL A 125
SER A 124
LEU A 144
 None
 1.37A 2hc4A-3co8A:
undetectable		 2hc4A-3co8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 ARG A  10
ILE A  11
PHE A 246
GLY A 286
LEU A 290
 None
 1.19A 2lbdA-3co8A:
undetectable		 2lbdA-3co8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 8 ARG A 367
SER A 350
GLY A 288
TRP A 289
 None
 1.04A 2qd3A-3co8A:
undetectable		 2qd3A-3co8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 9 LEU A 248
ILE A 333
GLY A 334
SER A 250
LEU A 298
 None
 1.06A 3ai9X-3co8A:
undetectable		 3ai9X-3co8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 7 VAL A 200
THR A 165
ILE A 189
THR A 131
 None
 0.82A 3deuA-3co8A:
undetectable		 3deuA-3co8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 6 THR A 165
ILE A 189
LEU A 188
THR A 131
 None
 0.93A 3deuB-3co8A:
undetectable		 3deuB-3co8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 LEU A  18
VAL A  22
GLY A 228
TYR A 227
TYR A  43
 None
None
None
None
PLP  A 401 (-4.6A)
 1.32A 3hgiA-3co8A:
undetectable		 3hgiA-3co8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 ASN A  21
VAL A 225
VAL A 245
TYR A  43
GLY A 228
 None
None
None
PLP  A 401 (-4.6A)
None
 1.34A 3medA-3co8A:
undetectable
3medB-3co8A:
undetectable		 3medA-3co8A:
20.57
3medB-3co8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 GLY A  70
ALA A  72
ILE A  84
LEU A  62
VAL A  64
 None
 1.10A 4azsA-3co8A:
undetectable		 4azsA-3co8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 GLY A  70
ALA A  72
ILE A  84
LEU A  62
VAL A  64
 None
 1.13A 4aztA-3co8A:
undetectable		 4aztA-3co8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 GLY A  70
ALA A  72
ILE A  84
LEU A  62
VAL A  64
 None
 1.12A 4azwA-3co8A:
2.2		 4azwA-3co8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 GLN A 303
SER A 336
LEU A 299
LEU A 252
CYH A 305
 None
 1.40A 4k38A-3co8A:
3.9
4k38D-3co8A:
undetectable		 4k38A-3co8A:
23.56
4k38D-3co8A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 GLN A 303
SER A 336
LEU A 299
VAL A 330
CYH A 305
 None
 1.34A 4k38A-3co8A:
3.9
4k38D-3co8A:
undetectable		 4k38A-3co8A:
23.56
4k38D-3co8A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 TYR A 324
GLN A 303
SER A 336
LEU A 299
LEU A 252
 None
 1.38A 4k38A-3co8A:
3.9
4k38D-3co8A:
undetectable		 4k38A-3co8A:
23.56
4k38D-3co8A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 6 TYR A 208
GLY A 234
GLU A 230
ASP A 240
 None
 1.00A 5emlA-3co8A:
6.6		 5emlA-3co8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 ILE A 333
SER A  17
GLU A  12
PHE A 246
GLY A 334
 None
 1.37A 5il1A-3co8A:
undetectable		 5il1A-3co8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 SER A  65
GLY A 223
THR A 224
VAL A 226
LEU A  36
 None
PLP  A 401 (-3.6A)
PLP  A 401 (-3.8A)
None
None
 1.19A 5kocB-3co8A:
undetectable		 5kocB-3co8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 GLY A 223
VAL A 225
VAL A 229
ILE A  53
ALA A  54
 PLP  A 401 (-3.6A)
None
None
None
None
 1.06A 5n0sA-3co8A:
undetectable		 5n0sA-3co8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		5 / 12 GLY A 223
VAL A 225
VAL A 229
ILE A  53
ALA A  54
 PLP  A 401 (-3.6A)
None
None
None
None
 1.09A 5n0tA-3co8A:
undetectable		 5n0tA-3co8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 4 LEU A  36
LEU A  34
SER A 203
ALA A 220
 None
None
PLP  A 401 (-2.6A)
None
 0.99A 5uunA-3co8A:
undetectable		 5uunA-3co8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		4 / 6 LEU A 123
VAL A 125
LEU A 151
VAL A 105
 None
 0.90A 5x7zA-3co8A:
undetectable		 5x7zA-3co8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3co8 ALANINE RACEMASE
(Oenococcus
oeni) 		3 / 3 LYS A 243
SER A  14
SER A  16
 None
 0.92A 6gbfA-3co8A:
undetectable		 6gbfA-3co8A:
21.76