SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		4 / 5 ASP A1173
SER A1172
ASN A1212
SER A1113
 None
 1.46A 1kiaB-3cobA:
undetectable		 1kiaB-3cobA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		4 / 6 ASP A1173
SER A1172
ASN A1212
SER A1113
 None
 1.44A 1kiaC-3cobA:
0.6		 1kiaC-3cobA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		3 / 3 ASP A 950
PHE A 938
ARG A 936
 None
 0.83A 2a3aA-3cobA:
undetectable		 2a3aA-3cobA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		4 / 8 THR A 990
GLY A1071
THR A 977
ILE A 980
 None
None
MG  A 601 ( 3.0A)
None
 0.97A 2f9wA-3cobA:
undetectable
2f9wB-3cobA:
undetectable		 2f9wA-3cobA:
21.43
2f9wB-3cobA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		5 / 11 LEU A1028
LEU A1027
ILE A1068
THR A 990
PRO A 991
 None
 1.29A 2ft9A-3cobA:
undetectable		 2ft9A-3cobA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		3 / 3 SER A1094
HIS A1090
ASP A1022
 None
 0.74A 2oxtA-3cobA:
undetectable		 2oxtA-3cobA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		3 / 3 HIS A 932
HIS A 922
HIS A1198
 None
 0.55A 2ozrF-3cobA:
undetectable		 2ozrF-3cobA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		3 / 3 ARG A 897
ARG A 895
PRO A 898
 None
ADP  A 600 (-4.0A)
ADP  A 600 (-4.7A)
 1.12A 2wljA-3cobA:
undetectable		 2wljA-3cobA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		4 / 4 PHE A 967
TYR A1203
VAL A1017
LEU A1091
 None
 1.38A 3keeD-3cobA:
undetectable		 3keeD-3cobA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		4 / 8 TYR A 981
ILE A 966
VAL A1093
THR A 990
 None
 0.82A 3p4wC-3cobA:
undetectable		 3p4wC-3cobA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		4 / 7 ASP A1195
ILE A 912
VAL A 920
TYR A 934
 None
 0.92A 3p6hA-3cobA:
undetectable		 3p6hA-3cobA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		3 / 3 ASP A1004
ARG A 999
LYS A1003
 None
 0.76A 3wipG-3cobA:
undetectable		 3wipG-3cobA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		4 / 7 ILE A 980
THR A 990
VAL A1185
ASP A 935
 None
 1.29A 4iarA-3cobA:
undetectable		 4iarA-3cobA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		3 / 3 ARG A 897
PRO A1189
ASN A 910
 None
 0.99A 5jwaA-3cobA:
undetectable
5jwaH-3cobA:
undetectable		 5jwaA-3cobA:
21.69
5jwaH-3cobA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN
(Solanum
tuberosum) 		3 / 3 LYS A 930
HIS A1198
HIS A 932
 None
 1.42A 5oexD-3cobA:
undetectable		 5oexD-3cobA:
20.04