SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 ILE A 316
LEU A 314
GLY A 293
SER A 294
ILE A 320
 None
 1.27A 1kyvC-3cosA:
2.3
1kyvD-3cosA:
2.1		 1kyvC-3cosA:
19.66
1kyvD-3cosA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 ILE A 316
LEU A 314
GLY A 293
SER A 294
ILE A 320
 None
 1.27A 1kyvD-3cosA:
2.2
1kyvE-3cosA:
undetectable		 1kyvD-3cosA:
19.66
1kyvE-3cosA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 4 LEU A 206
VAL A 214
CYH A 217
ALA A 222
 None
 1.13A 1mz9E-3cosA:
undetectable		 1mz9E-3cosA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 8 LEU A 348
TYR A 186
GLY A 208
LEU A 178
 None
None
NAD  A 400 (-3.8A)
None
 1.03A 1s1xA-3cosA:
undetectable		 1s1xA-3cosA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 GLY A 187
PHE A 325
VAL A 209
ALA A 213
ALA A 188
 None
None
NAD  A 400 ( 3.8A)
None
None
 1.49A 2avdA-3cosA:
7.2		 2avdA-3cosA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		3 / 3 SER A 304
ASP A 273
CYH A 295
 None
 0.81A 2br4E-3cosA:
4.6		 2br4E-3cosA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 GLY A 207
GLY A 205
GLY A 181
GLU A  70
HIS A  48
 NAD  A 400 (-3.4A)
NAD  A 400 (-3.4A)
None
None
NAD  A 400 (-3.8A)
 0.74A 2fk8A-3cosA:
5.9		 2fk8A-3cosA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		6 / 12 ALA A 170
ASP A 169
ASP A 167
ILE A  74
PRO A  93
VAL A 175
 None
 1.23A 3el5B-3cosA:
undetectable		 3el5B-3cosA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 GLY A 205
ASP A 273
ILE A 298
VAL A 209
 NAD  A 400 (-3.4A)
None
NAD  A 400 (-4.8A)
NAD  A 400 ( 3.8A)
 0.88A 3fi0E-3cosA:
undetectable		 3fi0E-3cosA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 ILE A 374
GLY A 207
ALA A 213
ALA A 275
ALA A 238
 None
NAD  A 400 (-3.4A)
None
NAD  A 400 (-3.4A)
None
 1.02A 3jb3A-3cosA:
2.9		 3jb3A-3cosA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 8 ASP A 229
ILE A 228
GLY A 205
VAL A 268
SER A 199
 NAD  A 400 (-2.9A)
None
NAD  A 400 (-3.4A)
None
None
 1.30A 4acbB-3cosA:
2.6
4acbC-3cosA:
3.1		 4acbB-3cosA:
22.59
4acbC-3cosA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 6 VAL A  85
VAL A  75
ILE A  39
LEU A  94
 None
 0.91A 4l1wB-3cosA:
undetectable		 4l1wB-3cosA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 HIS A  69
PHE A 147
VAL A 300
PHE A  58
THR A  52
 ZN  A 501 ( 3.3A)
ACY  A 401 (-4.3A)
NAD  A 400 ( 4.2A)
None
None
 1.43A 4mubA-3cosA:
undetectable		 4mubA-3cosA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 7 ARG A 224
THR A 200
ASP A 269
GLY A 266
 None
 1.11A 5hwaA-3cosA:
undetectable		 5hwaA-3cosA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 6 GLY A 326
THR A 184
SER A 183
GLY A 181
 None
NAD  A 400 (-3.0A)
None
None
 0.80A 5k4pA-3cosA:
undetectable		 5k4pA-3cosA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		5 / 12 PHE A 380
LEU A  22
ASP A 359
PHE A 358
THR A  44
 None
 1.15A 5nknA-3cosA:
undetectable		 5nknA-3cosA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 6 LEU A  22
PHE A 365
ASP A 366
HIS A  48
 None
None
None
NAD  A 400 (-3.8A)
 1.10A 5om3A-3cosA:
undetectable
5om3B-3cosA:
undetectable		 5om3A-3cosA:
10.90
5om3B-3cosA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		3 / 3 LEU A 337
ILE A 334
TYR A  95
 None
None
ACY  A 401 (-3.6A)
 0.70A 5uunB-3cosA:
undetectable		 5uunB-3cosA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 6 GLU A 313
LEU A 314
LEU A 307
LEU A 285
 None
 1.16A 5yvnA-3cosA:
undetectable		 5yvnA-3cosA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens) 		4 / 6 THR A   3
GLN A  40
ARG A  38
ILE A   8
 None
 1.47A 6ef6A-3cosA:
undetectable		 6ef6A-3cosA:
19.55