SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		3 / 3 GLU A 474
ILE A 473
ARG A 465
 None
 0.66A 1cd2A-3cp2A:
undetectable		 1cd2A-3cp2A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 11 PRO A 403
LEU A 389
VAL A  63
GLY A  67
LEU A 455
 None
 1.20A 1fkpA-3cp2A:
undetectable		 1fkpA-3cp2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 6 GLU A  62
ARG A  27
LEU A 448
LEU A 389
 None
 0.97A 1mt1B-3cp2A:
undetectable
1mt1C-3cp2A:
undetectable		 1mt1B-3cp2A:
10.31
1mt1C-3cp2A:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 4 VAL A 152
ALA A 368
LEU A 353
PHE A 367
 None
 1.20A 1q97B-3cp2A:
undetectable		 1q97B-3cp2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 8 THR A  19
GLY A 384
ALA A 380
TYR A 104
 None
None
SO4  A 630 ( 3.7A)
None
 0.68A 2a1hA-3cp2A:
undetectable
2a1hB-3cp2A:
undetectable		 2a1hA-3cp2A:
19.31
2a1hB-3cp2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 8 TYR A 104
THR A  19
GLY A 384
ALA A 380
 None
None
None
SO4  A 630 ( 3.7A)
 0.72A 2a1hA-3cp2A:
undetectable
2a1hB-3cp2A:
undetectable		 2a1hA-3cp2A:
19.31
2a1hB-3cp2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 5 ALA A  99
ALA A  77
GLN A  44
VAL A 108
 None
 0.89A 2nyrB-3cp2A:
3.5		 2nyrB-3cp2A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 7 GLU A 379
GLY A  55
PHE A 227
ILE A  51
 None
 1.03A 2qmzA-3cp2A:
2.3
2qmzB-3cp2A:
2.3		 2qmzA-3cp2A:
17.60
2qmzB-3cp2A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 9 GLY A 137
ALA A 138
ASP A 127
VAL A 125
VAL A 152
 None
 0.95A 3oxvC-3cp2A:
undetectable		 3oxvC-3cp2A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 10 GLY A 137
ALA A 138
ASP A 127
VAL A 125
VAL A 152
 None
 0.96A 3oxwA-3cp2A:
undetectable		 3oxwA-3cp2A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 8 ALA A  73
LEU A  69
ASP A  64
SER A 228
 None
 1.00A 3qj7A-3cp2A:
undetectable
3qj7D-3cp2A:
undetectable		 3qj7A-3cp2A:
17.17
3qj7D-3cp2A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 12 ALA A 387
LEU A 357
ALA A  17
VAL A 135
ILE A 362
 None
None
SO4  A 630 (-3.2A)
None
None
 1.27A 3uvvB-3cp2A:
undetectable		 3uvvB-3cp2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 12 GLY A  13
GLY A  18
VAL A 155
THR A 154
LEU A 153
 None
None
SO4  A 630 ( 3.4A)
SO4  A 630 ( 4.6A)
None
 1.07A 4f84A-3cp2A:
2.5		 4f84A-3cp2A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		3 / 3 THR A 199
ASN A 372
PHE A 348
 None
 0.80A 4pd9A-3cp2A:
undetectable		 4pd9A-3cp2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.85A 4txnA-3cp2A:
undetectable		 4txnA-3cp2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.83A 4txnB-3cp2A:
undetectable		 4txnB-3cp2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.79A 4txnC-3cp2A:
undetectable		 4txnC-3cp2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 7 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.82A 4txnD-3cp2A:
undetectable		 4txnD-3cp2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		3 / 3 ARG A 479
TYR A 520
GLU A 476
 None
 0.65A 4zzbE-3cp2A:
undetectable		 4zzbE-3cp2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		3 / 3 ASN A  48
ALA A  50
ARG A  96
 None
 0.68A 5cvtB-3cp2A:
5.6		 5cvtB-3cp2A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 12 GLU A 441
THR A  95
GLY A  52
ILE A  51
TYR A 426
 None
 1.23A 5ifuA-3cp2A:
undetectable		 5ifuA-3cp2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		3 / 3 GLY A 376
GLN A 383
LYS A  56
 None
 0.96A 5imsB-3cp2A:
undetectable		 5imsB-3cp2A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 12 THR A  32
LEU A  66
LEU A 410
ALA A  22
GLY A 388
 None
 1.42A 5jglA-3cp2A:
3.9		 5jglA-3cp2A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 10 LEU A 153
ILE A  12
GLY A  13
GLY A  18
LEU A 365
 None
 1.10A 5twjB-3cp2A:
undetectable		 5twjB-3cp2A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 10 LEU A 389
VAL A 458
VAL A  63
GLY A  67
LEU A 455
 None
 1.38A 6bsiA-3cp2A:
undetectable		 6bsiA-3cp2A:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 5 LYS A 469
GLN A 537
GLY A  89
ILE A 544
 None
 1.34A 6debB-3cp2A:
undetectable		 6debB-3cp2A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		5 / 12 GLY A 137
ALA A 138
ASP A 127
VAL A 125
VAL A 152
 None
 0.94A 6dh6A-3cp2A:
undetectable		 6dh6A-3cp2A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Escherichia
coli) 		4 / 6 ALA A 138
GLY A  13
ILE A 371
PHE A 348
 None
 0.79A 6f8cA-3cp2A:
undetectable		 6f8cA-3cp2A:
8.65