SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 11 LEU A 116
ASP A 118
VAL A   7
GLY A 122
ILE A  30
 None
 0.95A 1c6yA-3cp8A:
undetectable		 1c6yA-3cp8A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		3 / 3 MET A 476
LEU A 505
SER A 506
 None
 0.67A 1ee2A-3cp8A:
4.0		 1ee2A-3cp8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 10 LEU A 116
ASP A 118
VAL A   7
GLY A 122
ILE A  30
 None
 0.94A 1hsgA-3cp8A:
undetectable		 1hsgA-3cp8A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 5 PRO A 198
TYR A 304
MET A 303
GLU A 294
 None
 1.41A 1m9jA-3cp8A:
0.7		 1m9jA-3cp8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 9 LEU A 116
ASP A 118
VAL A   7
GLY A 122
ILE A  30
 None
 0.95A 1ohrB-3cp8A:
undetectable		 1ohrB-3cp8A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 10 ARG A  22
GLY A  66
SER A 224
ASP A  70
ILE A  69
 None
 1.41A 1pw7A-3cp8A:
2.1		 1pw7A-3cp8A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 9 LEU A 116
ASP A 118
VAL A   7
GLY A 122
ILE A  30
 None
 1.02A 2o4pB-3cp8A:
undetectable		 2o4pB-3cp8A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 4 ARG A 169
GLY A 167
GLU A 173
SER A 311
 FAD  A 622 (-3.6A)
None
None
None
 1.41A 2xctS-3cp8A:
undetectable
2xctU-3cp8A:
undetectable		 2xctS-3cp8A:
23.18
2xctU-3cp8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 9 LEU A 116
ASP A 118
VAL A   7
GLY A 122
ILE A  30
 None
 0.92A 3ekqB-3cp8A:
undetectable		 3ekqB-3cp8A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 10 ALA A 529
GLU A 531
LEU A 515
LEU A 532
LEU A 505
 None
 1.34A 3erdB-3cp8A:
undetectable		 3erdB-3cp8A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 8 ASP A 278
GLY A 307
SER A 309
ILE A 276
 None
None
FAD  A 622 ( 4.4A)
None
 0.69A 3ihzB-3cp8A:
undetectable		 3ihzB-3cp8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 7 ARG A  56
ASP A  70
PHE A 225
ARG A 537
 None
 1.49A 3kivA-3cp8A:
undetectable		 3kivA-3cp8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 7 ARG A 445
ASP A 458
ASP A 457
ARG A 537
 None
 1.21A 3kivA-3cp8A:
undetectable		 3kivA-3cp8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 11 GLN A 379
ALA A 383
ALA A   9
GLY A  10
ALA A 149
 None
None
None
FAD  A 622 (-3.4A)
None
 1.13A 3mg0V-3cp8A:
undetectable
3mg0W-3cp8A:
undetectable		 3mg0V-3cp8A:
15.99
3mg0W-3cp8A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 12 ILE A 113
GLU A 110
GLU A  15
GLY A 380
VAL A   6
 None
 1.42A 3rlbB-3cp8A:
undetectable		 3rlbB-3cp8A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 12 GLN A 379
GLY A 365
LEU A 148
GLU A  15
ALA A  16
 None
FAD  A 622 (-3.3A)
None
None
None
 1.19A 3sxjA-3cp8A:
undetectable		 3sxjA-3cp8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 12 GLN A 379
GLY A 365
LEU A 148
GLU A  15
ALA A  16
 None
FAD  A 622 (-3.3A)
None
None
None
 1.20A 3sxjB-3cp8A:
undetectable		 3sxjB-3cp8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 5 SER A 309
THR A 197
GLU A 277
ASP A 256
 FAD  A 622 ( 4.4A)
None
None
None
 1.29A 3tm4A-3cp8A:
3.4		 3tm4A-3cp8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 5 SER A 309
THR A 197
GLU A 277
ASP A 256
 FAD  A 622 ( 4.4A)
None
None
None
 1.30A 3tm4B-3cp8A:
3.8		 3tm4B-3cp8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 8 THR A 355
ARG A 356
GLY A 187
PHE A 188
 None
 1.10A 3tzfB-3cp8A:
undetectable		 3tzfB-3cp8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 6 PHE A 344
PHE A 363
LEU A 361
PHE A 130
 None
 1.00A 3wg7P-3cp8A:
undetectable
3wg7W-3cp8A:
undetectable		 3wg7P-3cp8A:
16.93
3wg7W-3cp8A:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		3 / 3 LEU A 519
GLU A 520
SER A 522
 None
 0.70A 4ccqA-3cp8A:
12.2		 4ccqA-3cp8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 8 SER A 275
ARG A 252
ILE A 276
PHE A 255
 None
 1.25A 4cx7A-3cp8A:
undetectable
4cx7B-3cp8A:
undetectable		 4cx7A-3cp8A:
20.49
4cx7B-3cp8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 8 SER A 275
ARG A 252
ILE A 276
PHE A 255
 None
 1.24A 4cx7C-3cp8A:
undetectable
4cx7D-3cp8A:
undetectable		 4cx7C-3cp8A:
20.49
4cx7D-3cp8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 10 ARG A 322
ALA A 330
LEU A 321
GLY A 320
ALA A  45
 None
 1.28A 4fe1A-3cp8A:
undetectable
4fe1J-3cp8A:
undetectable		 4fe1A-3cp8A:
22.69
4fe1J-3cp8A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 10 LEU A 116
ASP A 118
VAL A   7
GLY A 122
ILE A  30
 None
 0.99A 4njuB-3cp8A:
undetectable		 4njuB-3cp8A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		3 / 3 THR A 195
ASN A 368
PHE A 344
 FAD  A 622 (-3.0A)
None
None
 0.72A 4pd9A-3cp8A:
undetectable		 4pd9A-3cp8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 11 LEU A 116
ASP A 118
VAL A   7
GLY A 122
ILE A  30
 None
 0.89A 4qgiB-3cp8A:
undetectable		 4qgiB-3cp8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 5 ILE A   5
PHE A 153
SER A 132
ASP A 118
 None
FAD  A 622 (-4.0A)
None
None
 1.42A 4rzvB-3cp8A:
undetectable		 4rzvB-3cp8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 5 ILE A 210
PRO A 325
HIS A 248
VAL A 305
 None
 1.23A 4s0vA-3cp8A:
undetectable		 4s0vA-3cp8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		3 / 3 ILE A  54
ILE A  46
MET A 424
 None
 0.68A 5i9yA-3cp8A:
undetectable		 5i9yA-3cp8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 6 PRO A  44
GLU A 314
ALA A 330
LEU A 327
 None
 0.96A 5igiA-3cp8A:
undetectable		 5igiA-3cp8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 7 ILE A 598
LEU A 615
LEU A 579
PRO A 595
 None
 0.99A 5u4sA-3cp8A:
4.4		 5u4sA-3cp8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		3 / 3 ILE A 291
VAL A 305
PRO A 199
 None
 0.70A 5uunA-3cp8A:
undetectable		 5uunA-3cp8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 8 GLY A  10
ALA A  38
CYH A  14
GLY A  13
GLU A  15
 FAD  A 622 (-3.4A)
None
None
None
None
 1.34A 5vw9A-3cp8A:
3.0		 5vw9A-3cp8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		4 / 6 PHE A 344
PHE A 363
LEU A 361
PHE A 130
 None
 1.11A 5z85P-3cp8A:
undetectable
5z85W-3cp8A:
undetectable		 5z85P-3cp8A:
16.93
5z85W-3cp8A:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 12 GLY A 254
GLN A 317
ARG A 257
ILE A 160
ASP A 163
 None
 1.34A 6bxnB-3cp8A:
3.1		 6bxnB-3cp8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		3 / 3 LEU A 615
LEU A 579
ARG A 618
 None
 0.68A 6fgcA-3cp8A:
undetectable		 6fgcA-3cp8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		3 / 3 LEU A 615
LEU A 579
ARG A 618
 None
 0.63A 6fgdA-3cp8A:
3.4		 6fgdA-3cp8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 12 GLN A 379
ALA A 383
ALA A   9
GLY A  10
ALA A 149
 None
None
None
FAD  A 622 (-3.4A)
None
 1.06A 6hwdH-3cp8A:
undetectable
6hwdI-3cp8A:
undetectable		 6hwdH-3cp8A:
9.74
6hwdI-3cp8A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA
(Chlorobaculum
tepidum) 		5 / 11 GLN A 379
ALA A 383
ALA A   9
GLY A  10
ALA A 149
 None
None
None
FAD  A 622 (-3.4A)
None
 1.06A 6hwdV-3cp8A:
undetectable		 6hwdV-3cp8A:
9.74