SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cpf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1
(Homo
sapiens) 		5 / 10 ALA A 145
GLU A 144
LEU A 101
ARG A 109
ILE A 123
 UNX  A   6 ( 3.9A)
UNX  A   5 (-3.9A)
UNX  A   1 (-3.8A)
None
None
 1.48A 1qkuA-3cpfA:
undetectable		 1qkuA-3cpfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1
(Homo
sapiens) 		5 / 10 ALA A 145
GLU A 144
LEU A 101
ARG A 109
ILE A 123
 UNX  A   6 ( 3.9A)
UNX  A   5 (-3.9A)
UNX  A   1 (-3.8A)
None
None
 1.49A 1qkuB-3cpfA:
undetectable		 1qkuB-3cpfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1
(Homo
sapiens) 		5 / 11 GLY A 130
ASP A 128
ILE A 123
GLY A  93
ILE A  92
 UNX  A   4 ( 3.7A)
None
None
None
None
 1.05A 3ebzB-3cpfA:
undetectable		 3ebzB-3cpfA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1
(Homo
sapiens) 		3 / 3 GLU A 144
LEU A 112
LEU A 134
 UNX  A   5 (-3.9A)
UNX  A   1 (-4.1A)
None
 0.76A 3ohtA-3cpfA:
undetectable		 3ohtA-3cpfA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1
(Homo
sapiens) 		3 / 3 GLU A 144
LEU A 112
LEU A 134
 UNX  A   5 (-3.9A)
UNX  A   1 (-4.1A)
None
 0.76A 3ohtB-3cpfA:
undetectable		 3ohtB-3cpfA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1
(Homo
sapiens) 		5 / 12 GLY A 130
ASP A 128
ILE A 123
GLY A  93
ILE A  92
 UNX  A   4 ( 3.7A)
None
None
None
None
 1.08A 3s56A-3cpfA:
undetectable		 3s56A-3cpfA:
21.90