SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  45
LEU A  36
SER A 162
 GDP  A 302 (-4.4A)
None
GDP  A 302 (-3.2A)
 0.70A 1e7aA-3cphA:
undetectable		 1e7aA-3cphA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 100
ASN A 133
GLU A 160
GLY A 132
 None
GDP  A 302 (-3.4A)
None
None
 1.08A 1ykiA-3cphA:
undetectable
1ykiB-3cphA:
undetectable		 1ykiA-3cphA:
23.71
1ykiB-3cphA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 100
ASN A 133
GLU A 160
GLY A 132
 None
GDP  A 302 (-3.4A)
None
None
 1.08A 1ykiA-3cphA:
undetectable
1ykiB-3cphA:
undetectable		 1ykiA-3cphA:
23.71
1ykiB-3cphA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 114
THR A  76
TYR A  89
 None
 1.05A 2a3aA-3cphA:
undetectable		 2a3aA-3cphA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 114
THR A  76
TYR A  89
 None
 1.07A 2a3aB-3cphA:
3.2		 2a3aB-3cphA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 114
THR A  76
TYR A  89
 None
 1.08A 2a3bA-3cphA:
3.2		 2a3bA-3cphA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.91A 2rctA-3cphA:
undetectable		 2rctA-3cphA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  80
GLY A  78
ALA A  77
HIS A 121
TYR A  90
 GDP  A 302 ( 4.7A)
None
None
None
None
 1.42A 4bupA-3cphA:
undetectable		 4bupA-3cphA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 178
ILE A  64
VAL A  62
LEU A  71
 None
 0.96A 4em2A-3cphA:
undetectable		 4em2A-3cphA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  23
ALA A 177
PHE A 173
LEU A  36
ILE A  97
 None
 1.05A 4km2B-3cphA:
undetectable		 4km2B-3cphA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  45
SER A  48
THR A  52
ASP A  75
 GDP  A 302 (-4.4A)
None
None
MG  A 301 ( 4.1A)
 1.11A 4qb9D-3cphA:
undetectable		 4qb9D-3cphA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.90A 4qynA-3cphA:
undetectable		 4qynA-3cphA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.91A 4qzuC-3cphA:
undetectable		 4qzuC-3cphA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  33
GLN A 113
ASN A 110
 GDP  A 302 (-2.6A)
None
None
 0.78A 5l2tA-3cphA:
undetectable		 5l2tA-3cphA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3cph RAS-RELATED PROTEIN
SEC4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  23
ALA A 177
PHE A 173
LEU A  36
ILE A  97
 None
 1.06A 7dfrA-3cphA:
undetectable		 7dfrA-3cphA:
21.92