SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 10 ALA G 292
GLY G  16
ARG G 434
LEU G 411
PRO G 400
 None
 1.26A 1cmcA-3cpiG:
undetectable
1cmcB-3cpiG:
undetectable		 1cmcA-3cpiG:
11.73
1cmcB-3cpiG:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 11 ARG G 434
LEU G 411
PRO G 400
ALA G 292
GLY G  16
 None
 1.34A 1mjqA-3cpiG:
undetectable
1mjqB-3cpiG:
undetectable		 1mjqA-3cpiG:
11.73
1mjqB-3cpiG:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 10 ARG G 434
LEU G 411
PRO G 400
ALA G 292
GLY G  16
 None
 1.29A 1mjqC-3cpiG:
undetectable
1mjqD-3cpiG:
undetectable		 1mjqC-3cpiG:
11.73
1mjqD-3cpiG:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 11 ARG G 434
LEU G 411
PRO G 400
ALA G 292
GLY G  16
 None
 1.28A 1mjqI-3cpiG:
undetectable
1mjqJ-3cpiG:
undetectable		 1mjqI-3cpiG:
11.73
1mjqJ-3cpiG:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 11 ILE G  85
PRO G 243
VAL G 108
ALA G 346
VAL G 348
 None
 1.19A 1rv7A-3cpiG:
undetectable
1rv7B-3cpiG:
undetectable		 1rv7A-3cpiG:
12.67
1rv7B-3cpiG:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 7 VAL G  30
TYR G 296
ARG G 106
CYH G  22
 None
 1.23A 1t46A-3cpiG:
undetectable		 1t46A-3cpiG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU G 239
TYR G 415
THR G  20
ILE G  23
PHE G 421
 None
 1.46A 1xoqA-3cpiG:
undetectable		 1xoqA-3cpiG:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU G 239
TYR G 415
THR G  20
ILE G  23
PHE G 421
 None
 1.45A 1xoqB-3cpiG:
undetectable		 1xoqB-3cpiG:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 4 GLY G  75
SER G 356
ILE G 314
HIS G 359
 None
 1.40A 1yajJ-3cpiG:
undetectable		 1yajJ-3cpiG:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 10 TYR G 415
GLY G 240
GLY G  45
ALA G  48
ALA G  49
 None
 1.07A 2ej3B-3cpiG:
undetectable		 2ej3B-3cpiG:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 8 TYR G 415
GLY G 240
GLY G  45
ALA G  48
ALA G  49
 None
 1.04A 2ej3C-3cpiG:
undetectable		 2ej3C-3cpiG:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 8 MET G 197
ALA G 198
GLY G 194
ILE G 193
 None
 0.61A 2zm9A-3cpiG:
undetectable		 2zm9A-3cpiG:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA G 198
TYR G 180
VAL G 179
TYR G 205
ILE G 193
 None
 1.47A 3a65A-3cpiG:
undetectable		 3a65A-3cpiG:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 VAL G 266
LEU G 267
GLY G 277
LYS G   7
THR G 280
 None
 1.03A 3bjwF-3cpiG:
undetectable		 3bjwF-3cpiG:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 10 TYR G 410
LEU G  28
VAL G  12
PRO G 288
ASN G 408
 None
 1.32A 3nuvB-3cpiG:
0.0		 3nuvB-3cpiG:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 5 ILE G 394
ARG G 339
THR G 366
GLU G 369
 None
 1.39A 3ny4A-3cpiG:
undetectable		 3ny4A-3cpiG:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		3 / 3 PHE G 151
TYR G 205
TYR G 180
 None
 1.11A 4ffwA-3cpiG:
undetectable		 4ffwA-3cpiG:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 8 ASP G 293
ASP G  39
GLU G  47
ASP G  42
 None
 1.09A 4gkhC-3cpiG:
undetectable
4gkhK-3cpiG:
undetectable		 4gkhC-3cpiG:
19.39
4gkhK-3cpiG:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 8 ASP G 293
ASP G  39
GLU G  47
ASP G  42
 None
 1.06A 4gkiE-3cpiG:
undetectable
4gkiG-3cpiG:
undetectable		 4gkiE-3cpiG:
19.39
4gkiG-3cpiG:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 TYR G 234
PHE G 110
ASN G  81
SER G  50
LEU G  89
 None
 1.42A 4k39A-3cpiG:
undetectable		 4k39A-3cpiG:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 5 TYR G 227
SER G 223
ALA G  91
THR G  96
 None
 1.23A 5n0tA-3cpiG:
undetectable		 5n0tA-3cpiG:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 5 TYR G 227
SER G 223
ALA G  91
THR G  96
 None
 1.04A 5n0wB-3cpiG:
undetectable		 5n0wB-3cpiG:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		4 / 5 TYR G 227
SER G 223
ALA G  91
THR G  96
 None
 1.07A 5n4iA-3cpiG:
undetectable		 5n4iA-3cpiG:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 ASP G 326
LEU G  56
ASP G  83
ALA G 362
GLY G 358
 None
 1.19A 5syeB-3cpiG:
undetectable		 5syeB-3cpiG:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA G 292
GLY G  16
THR G  17
GLY G  18
PHE G 297
 None
 1.09A 5ybbA-3cpiG:
undetectable		 5ybbA-3cpiG:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 GLN G 329
ILE G 364
LEU G 328
ILE G 387
CYH G 313
 None
 0.99A 6a5zD-3cpiG:
undetectable		 6a5zD-3cpiG:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3cpi RAB GDP-DISSOCIATION
INHIBITOR
(Saccharomyces
cerevisiae) 		5 / 12 ILE G 100
ASN G  97
HIS G 101
LEU G  99
LEU G  27
 None
 1.28A 6chgC-3cpiG:
undetectable		 6chgC-3cpiG:
16.82