SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cpj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		3 / 3 PHE B  38
LEU B  29
SER B 156
 GDP  B1207 (-4.5A)
None
GDP  B1207 (-3.6A)
 0.83A 1e7aA-3cpjB:
undetectable		 1e7aA-3cpjB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  62
THR B 155
VAL B 163
LEU B  18
ILE B  66
 None
 1.09A 1kqwA-3cpjB:
undetectable		 1kqwA-3cpjB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		3 / 3 TRP B 107
THR B  69
TYR B  82
 None
 1.16A 2a3aB-3cpjB:
3.2		 2a3aB-3cpjB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 163
ASP B 164
GLU B 161
 None
 0.74A 2qeuC-3cpjB:
undetectable		 2qeuC-3cpjB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		4 / 8 PHE B 167
THR B 153
ILE B 124
THR B 155
 None
 0.98A 3bpxA-3cpjB:
undetectable
3bpxB-3cpjB:
undetectable		 3bpxA-3cpjB:
19.64
3bpxB-3cpjB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 111
LEU B 108
GLU B 110
ILE B  91
 None
 0.96A 4ww7A-3cpjB:
undetectable		 4ww7A-3cpjB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  16
ILE B 174
LEU B 170
ASP B 116
ALA B 115
 None
 1.00A 5km9B-3cpjB:
undetectable		 5km9B-3cpjB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		4 / 8 ASP B  68
LEU B  18
THR B  69
VAL B  24
 MG  B1208 ( 4.2A)
None
None
GDP  B1207 ( 4.3A)
 1.27A 5ov9B-3cpjB:
undetectable		 5ov9B-3cpjB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3cpj GTP-BINDING PROTEIN
YPT31/YPT8
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 150
ILE B 124
ALA B 166
ILE B 171
ALA B  64
 None
 1.17A 5vc0A-3cpjB:
undetectable		 5vc0A-3cpjB:
20.18