SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 7 SER A 154
THR A 119
VAL A 118
ALA A 178
 None
 1.01A 1fo4B-3cprA:
undetectable		 1fo4B-3cprA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 6 ARG A 228
GLY A  18
ASP A  52
TYR A 197
 None
 1.14A 1kf6M-3cprA:
0.1
1kf6N-3cprA:
undetectable		 1kf6M-3cprA:
19.77
1kf6N-3cprA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 7 ALA A 285
SER A 263
ILE A 283
ASP A 278
 None
 0.95A 1yc5A-3cprA:
undetectable		 1yc5A-3cprA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 10 TYR A 231
GLY A  18
GLY A  13
THR A  12
ALA A 195
 None
 1.16A 2ej3B-3cprA:
undetectable		 2ej3B-3cprA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		3 / 3 SER A 154
THR A 162
GLN A 127
 None
 0.78A 2fk8A-3cprA:
undetectable		 2fk8A-3cprA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 5 ILE A  89
SER A  53
GLY A  21
HIS A 221
 None
 0.90A 2otfA-3cprA:
undetectable		 2otfA-3cprA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 12 MET A  24
ALA A  43
VAL A 303
LEU A 269
LEU A 227
 None
 1.31A 2rctA-3cprA:
undetectable		 2rctA-3cprA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 5 ASP A 177
ILE A 158
VAL A 117
THR A  59
 None
None
None
MCL  A 176 ( 3.9A)
 1.03A 3eigA-3cprA:
undetectable		 3eigA-3cprA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 6 LEU A 259
GLU A 290
ASN A 287
SER A 263
 None
 1.40A 3i9jB-3cprA:
undetectable		 3i9jB-3cprA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 10 LEU A  72
ALA A 112
ILE A  89
GLY A  83
LEU A  75
 None
 1.13A 3ogpB-3cprA:
undetectable		 3ogpB-3cprA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  72
GLY A 111
ALA A 112
ILE A  89
GLY A  83
 None
 0.90A 3ogqB-3cprA:
undetectable		 3ogqB-3cprA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 5 ARG A 228
VAL A  22
LEU A  54
SER A  53
 None
 1.18A 4e1gA-3cprA:
undetectable		 4e1gA-3cprA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 9 THR A   9
LEU A 208
LEU A 227
PHE A 215
TYR A 197
 None
 1.38A 4ltwA-3cprA:
undetectable		 4ltwA-3cprA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 6 ILE A 216
PHE A 215
GLY A 199
ILE A 189
 MCL  A 176 ( 3.7A)
None
MCL  A 176 ( 3.7A)
None
 0.68A 4o8fB-3cprA:
undetectable		 4o8fB-3cprA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 12 MET A  24
ALA A  43
VAL A 303
LEU A 269
LEU A 227
 None
 1.27A 4qynA-3cprA:
undetectable		 4qynA-3cprA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A 110
LYS A  76
THR A  26
ALA A  57
VAL A  92
 None
 1.18A 4x1iB-3cprA:
undetectable		 4x1iB-3cprA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		4 / 7 VAL A 218
GLN A 256
LEU A 264
SER A 263
 None
 0.86A 4zphA-3cprA:
undetectable
4zphB-3cprA:
undetectable		 4zphA-3cprA:
20.75
4zphB-3cprA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3cpr DIHYDRODIPICOLINATE
SYNTHETASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  91
VAL A 101
ILE A  34
GLY A  61
SER A  63
 None
 1.19A 6c2mB-3cprA:
undetectable		 6c2mB-3cprA:
14.47