SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 8 ALA A 271
GLY A 185
ILE A 186
VAL A 280
ILE A 276
 None
 1.29A 1d4yB-3cpsA:
undetectable		 1d4yB-3cpsA:
14.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 7 ASN A 334
TYR A 338
ASN A 171
TYR A 332
 NAD  A 401 (-3.6A)
NAD  A 401 (-3.7A)
None
None
 0.95A 1dssG-3cpsA:
52.3		 1dssG-3cpsA:
59.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		7 / 7 SER A 167
THR A 169
ASN A 171
CYH A 172
TYR A 332
ASN A 334
TYR A 338
 None
None
None
None
None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.7A)
 0.20A 1dssG-3cpsA:
52.3		 1dssG-3cpsA:
59.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 ASN A 334
TYR A 338
ASN A 171
TYR A 332
 NAD  A 401 (-3.6A)
NAD  A 401 (-3.7A)
None
None
 0.94A 1dssR-3cpsA:
52.0		 1dssR-3cpsA:
59.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		8 / 8 SER A 167
THR A 169
ASN A 171
CYH A 172
HIS A 195
TYR A 332
ASN A 334
TYR A 338
 None
None
None
None
None
None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.7A)
 0.40A 1dssR-3cpsA:
52.0		 1dssR-3cpsA:
59.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 9 ILE A 186
VAL A 235
GLY A 236
ALA A 177
LEU A 173
 None
 0.94A 1e7bA-3cpsA:
undetectable		 1e7bA-3cpsA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 SER A 324
LEU A 173
LEU A 246
ALA A 241
ILE A 239
 None
 0.76A 2bxcA-3cpsA:
undetectable		 2bxcA-3cpsA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A 252
VAL A 261
THR A 169
 None
 0.80A 2nmzA-3cpsA:
undetectable		 2nmzA-3cpsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A 252
VAL A 261
THR A 169
 None
 0.79A 2nnkA-3cpsA:
undetectable		 2nnkA-3cpsA:
15.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 ASN A 334
TYR A 338
ASN A 171
TYR A 332
 NAD  A 401 (-3.6A)
NAD  A 401 (-3.7A)
None
None
 0.96A 3dmtC-3cpsA:
27.9		 3dmtC-3cpsA:
50.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		8 / 8 SER A 167
THR A 169
ASN A 171
CYH A 172
HIS A 195
TYR A 332
ASN A 334
TYR A 338
 None
None
None
None
None
None
NAD  A 401 (-3.6A)
NAD  A 401 (-3.7A)
 0.34A 3dmtC-3cpsA:
27.9		 3dmtC-3cpsA:
50.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 4 LEU A 342
MET A  37
ILE A  99
ASP A  49
 None
None
None
NAD  A 401 (-2.9A)
 1.40A 3hecA-3cpsA:
undetectable		 3hecA-3cpsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A 252
VAL A 261
THR A 169
 None
 0.80A 3k4vA-3cpsA:
undetectable		 3k4vA-3cpsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A 252
VAL A 261
THR A 169
 None
 0.80A 3k4vD-3cpsA:
undetectable		 3k4vD-3cpsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A 252
VAL A 261
THR A 169
 None
 0.81A 3nduD-3cpsA:
undetectable		 3nduD-3cpsA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A 252
VAL A 261
THR A 169
 None
 0.82A 3pwrA-3cpsA:
undetectable		 3pwrA-3cpsA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A 252
VAL A 261
THR A 169
 None
 0.81A 3tl9A-3cpsA:
undetectable		 3tl9A-3cpsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 PHE A  25
MET A  52
ILE A  47
VAL A  74
 None
 1.17A 4mk4B-3cpsA:
3.5		 4mk4B-3cpsA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A  21
VAL A 109
ILE A 108
ILE A  99
LEU A 126
 None
 0.96A 4pd4C-3cpsA:
undetectable		 4pd4C-3cpsA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 ARG A  27
ASP A  64
VAL A 258
ASP A 333
 None
 1.42A 4xqeA-3cpsA:
10.5		 4xqeA-3cpsA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 4 GLY A  78
VAL A  90
PHE A  70
ILE A  83
 None
 1.01A 4xv2B-3cpsA:
undetectable		 4xv2B-3cpsA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 THR A 170
ALA A 166
ASN A 171
 None
 0.58A 5ersA-3cpsA:
4.1		 5ersA-3cpsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 TYR A 338
SER A 167
THR A 169
PRO A 139
 NAD  A 401 (-3.7A)
None
None
None
 0.96A 5jhdE-3cpsA:
undetectable
5jhdG-3cpsA:
undetectable		 5jhdE-3cpsA:
23.04
5jhdG-3cpsA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 7 VAL A 326
LEU A 328
ALA A 320
LEU A 267
 None
 0.47A 5jq7A-3cpsA:
undetectable		 5jq7A-3cpsA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 10 ILE A  22
ILE A  47
VAL A  44
ASP A  80
ILE A  83
 None
 1.24A 5lg3H-3cpsA:
undetectable		 5lg3H-3cpsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 ARG A  34
HIS A  67
ARG A  27
 None
 1.19A 6dwdD-3cpsA:
undetectable		 6dwdD-3cpsA:
21.84