SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		5 / 11 ILE A 215
ASP A 287
GLY A 212
PHE A 242
VAL A 207
 None
 1.50A 1axwB-3cpxA:
undetectable		 1axwB-3cpxA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		5 / 12 ASN A  16
GLY A  70
SER A  68
ARG A 148
ILE A  82
 None
 1.30A 1q8jA-3cpxA:
undetectable		 1q8jA-3cpxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		5 / 11 SER A 195
LEU A 257
ILE A 166
HIS A  65
ALA A 154
 None
None
None
FE  A 400 (-3.2A)
None
 1.49A 2a58A-3cpxA:
2.6
2a58E-3cpxA:
4.3		 2a58A-3cpxA:
20.38
2a58E-3cpxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		5 / 11 ILE A 166
HIS A  65
ALA A 154
SER A 195
LEU A 257
 None
FE  A 400 (-3.2A)
None
None
None
 1.49A 2a58C-3cpxA:
4.3
2a58D-3cpxA:
4.2		 2a58C-3cpxA:
20.38
2a58D-3cpxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		4 / 8 LEU A  79
PRO A  13
SER A  68
GLY A  95
 None
 1.07A 2qd5B-3cpxA:
2.4		 2qd5B-3cpxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		4 / 7 VAL A  73
ILE A 121
GLY A 124
THR A 125
 None
 0.57A 2xrzB-3cpxA:
undetectable		 2xrzB-3cpxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		5 / 12 TYR A  27
LEU A   3
PHE A 168
VAL A 292
ALA A 158
 None
 1.49A 3nhxA-3cpxA:
0.0		 3nhxA-3cpxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		5 / 12 ILE A  28
ILE A  24
LEU A  25
ALA A 167
THR A 169
 None
 1.06A 3rukB-3cpxA:
undetectable		 3rukB-3cpxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		4 / 7 ASP A 146
GLU A 173
HIS A 277
GLU A 172
 FE  A 400 ( 2.4A)
FE  A 401 ( 2.0A)
FE  A 401 (-3.4A)
FE  A 400 (-3.7A)
 0.97A 4hvrA-3cpxA:
undetectable		 4hvrA-3cpxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		6 / 11 HIS A  65
ASP A 146
GLU A 172
GLU A 173
GLY A 250
HIS A 277
 FE  A 400 (-3.2A)
FE  A 400 ( 2.4A)
FE  A 400 (-3.7A)
FE  A 401 ( 2.0A)
EDO  A 404 (-4.1A)
FE  A 401 (-3.4A)
 0.42A 4pqaA-3cpxA:
22.3		 4pqaA-3cpxA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		4 / 8 ILE A 288
PRO A 143
THR A 142
PHE A 133
 None
 1.15A 5x23A-3cpxA:
undetectable		 5x23A-3cpxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		5 / 12 ALA A 180
LEU A 257
THR A 169
ALA A 167
TYR A 181
 EDO  A 406 (-3.5A)
None
None
None
None
 1.13A 6djzC-3cpxA:
undetectable		 6djzC-3cpxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3cpx AMINOPEPTIDASE, M42
FAMILY
(Cytophaga
hutchinsonii) 		4 / 6 ILE A  82
ALA A  12
MET A  66
ASP A 253
 None
 1.16A 6hu9m-3cpxA:
undetectable
6hu9q-3cpxA:
undetectable		 6hu9m-3cpxA:
21.40
6hu9q-3cpxA:
17.13