SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 330
ILE A  82
ARG A 112
 None
None
GOL  A 352 ( 3.6A)
 0.85A 1cd2A-3cq0A:
undetectable		 1cd2A-3cq0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  64
ILE A  89
ILE A  51
PHE A  93
LEU A  52
 None
 1.03A 1qhsA-3cq0A:
undetectable		 1qhsA-3cq0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 176
ALA A 177
GLY A 214
LEU A 216
LEU A 171
 None
 1.30A 2nv4B-3cq0A:
undetectable		 2nv4B-3cq0A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 222
VAL A 218
ILE A 188
ASP A 252
 None
 1.17A 2x45C-3cq0A:
undetectable		 2x45C-3cq0A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 THR A 211
ASP A 212
VAL A 215
VAL A 192
ASN A 241
 None
 1.24A 2y03B-3cq0A:
undetectable		 2y03B-3cq0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  33
GLY A  31
ALA A  54
LEU A 258
 None
 0.99A 3bgdA-3cq0A:
undetectable		 3bgdA-3cq0A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 110
LEU A 325
ASP A  87
LEU A 130
 GOL  A 352 ( 3.6A)
None
GOL  A 351 (-3.5A)
None
 1.19A 3bj8C-3cq0A:
undetectable
3bj8D-3cq0A:
undetectable		 3bj8C-3cq0A:
20.83
3bj8D-3cq0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 233
HIS A  25
ASN A 253
ILE A 251
 None
GOL  A 350 (-3.8A)
None
None
 1.12A 3kp6A-3cq0A:
undetectable
3kp6B-3cq0A:
undetectable		 3kp6A-3cq0A:
22.44
3kp6B-3cq0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 187
GLU A 233
ARG A 104
HIS A 165
 None
 1.43A 3ltwA-3cq0A:
undetectable		 3ltwA-3cq0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 171
ALA A 181
THR A 232
VAL A 234
VAL A 218
 None
 1.14A 3r9cA-3cq0A:
undetectable		 3r9cA-3cq0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		3 / 3 SER A 319
ASP A 313
ASP A 197
 GOL  A 356 (-4.9A)
None
None
 0.92A 3uj7A-3cq0A:
undetectable		 3uj7A-3cq0A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 9 ALA A  22
GLY A 250
LEU A 245
LEU A 275
ASN A 276
 None
 1.21A 3wdmC-3cq0A:
undetectable		 3wdmC-3cq0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 6 SER A 189
ASP A  43
ARG A 104
GLU A 233
 None
 1.09A 4eysA-3cq0A:
undetectable		 4eysA-3cq0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 MET A 254
LEU A 260
ILE A 271
LEU A 264
LEU A 248
 None
 1.17A 4j24D-3cq0A:
undetectable		 4j24D-3cq0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 5 THR A  45
THR A  24
LEU A 264
LEU A 261
 GOL  A 354 ( 4.4A)
None
None
None
 0.96A 4lvcB-3cq0A:
2.3		 4lvcB-3cq0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 134
VAL A  91
GLU A  92
ASP A  87
ILE A 127
 None
None
None
GOL  A 351 (-3.5A)
None
 1.22A 5i3cC-3cq0A:
undetectable		 5i3cC-3cq0A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 322
VAL A 329
ALA A  66
ALA A  67
THR A  95
 GOL  A 351 (-3.8A)
None
None
None
None
 1.25A 5igpA-3cq0A:
undetectable		 5igpA-3cq0A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 251
ASP A 212
LEU A  19
LEU A 264
MET A 254
 None
 1.16A 5nfjB-3cq0A:
undetectable		 5nfjB-3cq0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 251
ASP A 212
LEU A  19
LEU A 264
MET A 254
 None
 1.17A 5nfjC-3cq0A:
undetectable		 5nfjC-3cq0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  27
ASN A 253
ARG A 104
SER A 277
GLU A 233
 None
 1.37A 5v1tA-3cq0A:
4.7		 5v1tA-3cq0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  28
GLU A 108
LEU A  50
ILE A  51
VAL A 105
 None
 1.45A 5vlmE-3cq0A:
undetectable		 5vlmE-3cq0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 4 PHE A 198
ASP A 197
LEU A 202
LYS A 200
 None
 1.35A 6awvA-3cq0A:
undetectable		 6awvA-3cq0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3cq0 PUTATIVE
TRANSALDOLASE
YGR043C
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 209
THR A 208
TYR A 207
VAL A 215
 None
 0.96A 6cduA-3cq0A:
undetectable
6cduE-3cq0A:
undetectable		 6cduA-3cq0A:
22.87
6cduE-3cq0A:
22.87