SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
(Homo
sapiens) 		4 / 4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 0.98A 1q23A-3cqcA:
undetectable		 1q23A-3cqcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
(Homo
sapiens) 		4 / 4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 0.94A 1q23F-3cqcA:
undetectable		 1q23F-3cqcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
(Homo
sapiens) 		4 / 4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 0.93A 1q23K-3cqcA:
undetectable		 1q23K-3cqcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 9 GLY B 972
ALA A 878
SER A 882
LEU B 976
LEU A 900
 None
 1.25A 1y7iA-3cqcB:
undetectable		 1y7iA-3cqcB:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 8 TYR B1057
LEU B1055
LEU B1054
LYS B1050
 None
 1.01A 2wekA-3cqcB:
undetectable		 2wekA-3cqcB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 8 LEU B 953
LEU A 904
LEU A 919
ARG A 905
 None
 0.95A 2xn3A-3cqcB:
undetectable
2xn3B-3cqcB:
undetectable		 2xn3A-3cqcB:
21.33
2xn3B-3cqcB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 6 HIS B1004
THR B1007
LEU B1054
LEU B1031
 None
 1.16A 3bgdA-3cqcB:
undetectable		 3bgdA-3cqcB:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 5 ALA B 951
GLU B 947
ALA B 978
MET B 987
 None
 1.22A 3r9tC-3cqcB:
undetectable		 3r9tC-3cqcB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 TYR B1046
LEU B1069
LYS B1070
 None
 0.67A 3sueD-3cqcB:
undetectable		 3sueD-3cqcB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 7 ASP B1124
LEU B1071
GLN B1079
LEU B1078
 None
 0.91A 4ib4A-3cqcB:
4.3		 4ib4A-3cqcB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 12 LEU B 970
LEU B 973
LEU B 976
ALA B 977
LEU B 938
 None
 0.83A 4ltwA-3cqcB:
undetectable		 4ltwA-3cqcB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 LYS B1049
ASN B1040
ASP B1053
 None
 0.86A 4o1eA-3cqcB:
undetectable		 4o1eA-3cqcB:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
(Homo
sapiens) 		4 / 5 TYR A 818
GLU A 873
LEU A 861
GLN A 870
 None
 0.96A 4qztB-3cqcA:
undetectable		 4qztB-3cqcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 6 PHE B 964
LYS B 968
LEU B 971
ASN B 958
 None
 1.38A 4yv5B-3cqcB:
1.7		 4yv5B-3cqcB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 6 PHE B 964
LYS B 968
LEU B 971
ASN B 958
 None
 1.35A 4yv5A-3cqcB:
undetectable		 4yv5A-3cqcB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
(Homo
sapiens) 		3 / 3 PHE A 680
ASP A 676
LEU A 689
 None
 0.80A 5uhbC-3cqcA:
undetectable		 5uhbC-3cqcA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
(Homo
sapiens) 		3 / 3 PHE A 680
ASP A 676
LEU A 689
 None
 0.79A 5uhcC-3cqcA:
undetectable		 5uhcC-3cqcA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 4 LEU B 956
LEU B 953
SER B 936
ALA B 949
 None
 0.93A 5uunA-3cqcB:
undetectable		 5uunA-3cqcB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 4 ASP B1053
ILE B1032
PRO B1029
LEU B1054
 None
 1.40A 6mkeA-3cqcB:
undetectable		 6mkeA-3cqcB:
14.98