SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3crj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3crj TRANSCRIPTION
REGULATOR
(Haloarcula
marismortui) 		5 / 12 LEU A  59
LEU A  58
MET A  17
LEU A 107
LEU A  66
 None
 0.90A 1sqnB-3crjA:
undetectable		 1sqnB-3crjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3crj TRANSCRIPTION
REGULATOR
(Haloarcula
marismortui) 		3 / 3 GLN A  12
ILE A  16
TYR A  51
 None
 0.75A 1vifA-3crjA:
undetectable		 1vifA-3crjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3crj TRANSCRIPTION
REGULATOR
(Haloarcula
marismortui) 		5 / 12 ALA A 183
LEU A  90
LEU A  94
ALA A 191
ILE A 163
 None
 1.22A 3lbdA-3crjA:
undetectable		 3lbdA-3crjA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3crj TRANSCRIPTION
REGULATOR
(Haloarcula
marismortui) 		4 / 8 HIS A 155
LEU A  93
LEU A 135
SER A 159
 None
 1.02A 3lm8B-3crjA:
undetectable
3lm8D-3crjA:
undetectable		 3lm8B-3crjA:
24.02
3lm8D-3crjA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3crj TRANSCRIPTION
REGULATOR
(Haloarcula
marismortui) 		3 / 3 HIS A  27
ARG A  36
GLU A  40
 None
 0.97A 3qf1A-3crjA:
undetectable		 3qf1A-3crjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3crj TRANSCRIPTION
REGULATOR
(Haloarcula
marismortui) 		3 / 3 SER A 159
ASP A 144
ASP A 152
 None
 0.71A 4uckA-3crjA:
undetectable		 4uckA-3crjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3crj TRANSCRIPTION
REGULATOR
(Haloarcula
marismortui) 		5 / 9 ALA A 106
GLN A  18
LEU A 103
ARG A  22
ARG A  25
 None
 1.40A 4x30A-3crjA:
undetectable		 4x30A-3crjA:
19.85