SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3crn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FE2_A_LAXA700_2 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	3crn	RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE (Methanospirillum hungatei)	5 / 12	PHE A 51 PHE A 90 GLY A 60 GLY A 37 LEU A 38	None None PHD A 52 ( 3.3A) None None	0.97A	1fe2A-3crnA: undetectable	1fe2A-3crnA: 12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NH8_A_HISA289_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	3crn	RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE (Methanospirillum hungatei)	4 / 5	ASP A 8 LEU A 63 ALA A 31 LEU A 14	PHD A 52 ( 3.6A) None None None	1.12A	1nh8A-3crnA: undetectable	1nh8A-3crnA: 17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_B_D16B520_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	3crn	RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE (Methanospirillum hungatei)	5 / 12	ASP A 108 LEU A 109 ILE A 13 SER A 16 LEU A 50	GOL A 133 (-2.8A) None None None None	1.17A	3nrrB-3crnA: undetectable	3nrrB-3crnA: 14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LJ0_A_ACTA505_0 (NAB2)	3crn	RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE (Methanospirillum hungatei)	3 / 3	LEU A 21 LYS A 18 THR A 17	None	0.52A	4lj0A-3crnA: undetectable	4lj0A-3crnA: 16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O1Z_A_MXMA807_2 (PROSTAGLANDIN G/H SYNTHASE 1)	3crn	RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE (Methanospirillum hungatei)	4 / 6	VAL A 7 LEU A 5 LEU A 38 PHE A 90	None	1.02A	4o1zA-3crnA: undetectable	4o1zA-3crnA: 12.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FE2_A_LAXA700_2","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","3crn","RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE","Methanospirillum hungatei",5,"PHE A  51;PHE A  90;GLY A  60;GLY A  37;LEU A  38","None;None;PHD A  52 ( 3.3A);None;None","0.97A","1fe2A-3crnA:undetectable","1fe2A-3crnA:12.02"],["1NH8_A_HISA289_0","ATP PHOSPHORIBOSYLTRANSFERASE","3crn","RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE","Methanospirillum hungatei",4,"ASP A   8;LEU A  63;ALA A  31;LEU A  14","PHD A  52 ( 3.6A);None;None;None","1.12A","1nh8A-3crnA:undetectable","1nh8A-3crnA:17.11"],["3NRR_B_D16B520_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","3crn","RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE","Methanospirillum hungatei",5,"ASP A 108;LEU A 109;ILE A  13;SER A  16;LEU A  50","GOL A 133 (-2.8A);None;None;None;None","1.17A","3nrrB-3crnA:undetectable","3nrrB-3crnA:14.35"],["4LJ0_A_ACTA505_0","NAB2","3crn","RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE","Methanospirillum hungatei",3,"LEU A  21;LYS A  18;THR A  17","None","0.52A","4lj0A-3crnA:undetectable","4lj0A-3crnA:16.28"],["4O1Z_A_MXMA807_2","PROSTAGLANDIN G\/H SYNTHASE 1","3crn","RESPONSE REGULATOR RECEIVER DOMAIN PROTEIN, CHEY-LIKE","Methanospirillum hungatei",4,"VAL A   7;LEU A   5;LEU A  38;PHE A  90","None","1.02A","4o1zA-3crnA:undetectable","4o1zA-3crnA:12.17"]]