SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3crr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  21
LEU A  98
LEU A  29
LEU A  10
 None
 0.83A 1yajD-3crrA:
undetectable		 1yajD-3crrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A 103
VAL A 100
PHE A  79
ALA A  83
 None
 1.11A 2ij7C-3crrA:
undetectable		 2ij7C-3crrA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 288
LEU A 216
ALA A  15
LEU A  33
LEU A  57
 TRS  A 327 ( 4.9A)
None
DPO  A 326 (-4.6A)
None
None
 1.30A 3b0wB-3crrA:
undetectable		 3b0wB-3crrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 ILE A   8
ALA A  24
LEU A  25
LEU A 316
ALA A 204
 None
 1.09A 3ozvB-3crrA:
undetectable		 3ozvB-3crrA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 288
LEU A 216
ARG A 213
ILE A 220
ALA A  15
 TRS  A 327 ( 4.9A)
None
None
None
DPO  A 326 (-4.6A)
 1.31A 5xprA-3crrA:
undetectable		 5xprA-3crrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 252
SER A 251
ALA A 238
LEU A 264
 None
 0.94A 6dwnA-3crrA:
undetectable		 6dwnA-3crrA:
13.87