SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 7 TYR A   7
GLY A  12
TYR A 111
GLY A 205
 None
 0.56A 11gsB-3cruA:
26.0		 11gsB-3cruA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 7 TYR A 111
GLY A 205
TYR A   7
GLY A  12
 None
 0.69A 11gsB-3cruA:
26.0		 11gsB-3cruA:
29.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		3 / 3 GLN A  67
TYR A 104
ARG A 108
 GSH  A 215 (-3.2A)
None
None
 0.76A 1gtbA-3cruA:
36.2		 1gtbA-3cruA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 11 TYR A 164
PRO A  16
LEU A  19
ARG A  18
ALA A 200
 None
 1.15A 1hk3A-3cruA:
undetectable		 1hk3A-3cruA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 5 TYR A 104
ALA A 110
ALA A 158
MET A 129
 None
 1.10A 3d91A-3cruA:
undetectable		 3d91A-3cruA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		3 / 3 GLU A  34
GLU A  37
TRP A   8
 None
None
GSH  A 215 (-4.2A)
 1.35A 3hrdA-3cruA:
undetectable
3hrdE-3cruA:
undetectable
3hrdF-3cruA:
undetectable		 3hrdA-3cruA:
17.06
3hrdE-3cruA:
17.06
3hrdF-3cruA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 TYR A   7
GLY A  12
TYR A 111
GLY A 205
 None
 0.64A 3n9jB-3cruA:
25.8		 3n9jB-3cruA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 TYR A 111
GLY A 205
TYR A   7
GLY A  12
 None
 0.77A 3n9jB-3cruA:
25.8		 3n9jB-3cruA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 6 GLU A 184
ILE A 189
GLU A  30
VAL A  14
 None
 0.92A 4ejwB-3cruA:
undetectable		 4ejwB-3cruA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 GLY A  83
GLY A  84
ILE A  92
GLU A  96
ASN A  80
 None
 1.13A 4fr0A-3cruA:
undetectable		 4fr0A-3cruA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 ASP A 101
TYR A 104
GLY A  97
ALA A 158
 None
 0.73A 4m48A-3cruA:
undetectable		 4m48A-3cruA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 SER A 107
LEU A 126
MET A 129
ARG A 103
LEU A 159
 None
 1.11A 4x1gA-3cruA:
undetectable		 4x1gA-3cruA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 9 LEU A   5
GLY A   6
ILE A  75
VAL A  14
THR A  17
 None
 1.16A 4x3mA-3cruA:
undetectable		 4x3mA-3cruA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 9 LEU A   5
GLY A   6
ILE A  75
VAL A  14
THR A  17
 None
 1.15A 4x3mB-3cruA:
undetectable		 4x3mB-3cruA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 7 VAL A 106
SER A 107
ALA A 110
GLY A 211
 None
 0.49A 5fpdA-3cruA:
undetectable		 5fpdA-3cruA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 7 VAL A 106
SER A 107
ALA A 110
GLY A 211
 None
 0.49A 5fpdB-3cruA:
undetectable		 5fpdB-3cruA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 THR A  17
PRO A  16
ILE A  71
PRO A  56
 None
None
None
GSH  A 215 (-4.4A)
 1.03A 6a4iA-3cruA:
undetectable		 6a4iA-3cruA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 LEU A 170
ALA A 158
LEU A 143
LEU A 130
LEU A 176
 None
 0.91A 6f6iA-3cruA:
undetectable
6f6iB-3cruA:
undetectable		 6f6iA-3cruA:
15.49
6f6iB-3cruA:
14.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 5 GLY A  12
LEU A  13
SER A 107
TYR A 111
GLN A 204
 None
GSH  A 215 (-4.5A)
None
None
None
 0.24A 6ji6A-3cruA:
36.6		 6ji6A-3cruA:
99.53