SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3crw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		3 / 3 ARG 1  55
SER 1 322
TYR 1 156
 None
 0.81A 2q2hA-3crw1:
undetectable
2q2hB-3crw1:
undetectable		 2q2hA-3crw1:
13.13
2q2hB-3crw1:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 8 VAL 1 525
SER 1 368
TYR 1 358
VAL 1 399
 None
 1.18A 2y05A-3crw1:
undetectable
2y05B-3crw1:
undetectable		 2y05A-3crw1:
22.18
2y05B-3crw1:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 7 VAL 1 298
LYS 1 300
TYR 1 234
GLU 1 232
 None
 1.12A 3hs4A-3crw1:
undetectable		 3hs4A-3crw1:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU 1 308
PHE 1 160
ILE 1 179
ALA 1 182
LEU 1 325
 None
 1.03A 3n8xB-3crw1:
undetectable		 3n8xB-3crw1:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 7 GLY 1 323
PRO 1  30
ASN 1  28
GLY 1  34
 None
 0.86A 3tajA-3crw1:
undetectable		 3tajA-3crw1:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 8 PHE 1 167
PRO 1 157
GLY 1  83
SER 1  97
 None
 1.08A 3tzfB-3crw1:
undetectable		 3tzfB-3crw1:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 7 GLY 1 323
PRO 1  30
ASN 1  28
GLY 1  34
 None
 0.82A 4forA-3crw1:
undetectable		 4forA-3crw1:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 5 LYS 1 539
LEU 1 541
LEU 1 505
LYS 1 509
 None
 1.34A 4k4yA-3crw1:
undetectable		 4k4yA-3crw1:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 5 LYS 1 539
LEU 1 541
LEU 1 505
LYS 1 509
 None
 1.36A 4k4yI-3crw1:
undetectable		 4k4yI-3crw1:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		5 / 12 MET 1 331
PRO 1 326
TYR 1 156
ASN 1 312
ILE 1 179
 None
 1.21A 4xe0A-3crw1:
undetectable		 4xe0A-3crw1:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		5 / 12 MET 1 331
TYR 1 156
VAL 1 188
ASN 1 312
ILE 1 179
 None
 1.42A 4xe0A-3crw1:
undetectable		 4xe0A-3crw1:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU 1  24
LEU 1 320
ILE 1 318
LEU 1 316
ILE 1 177
 None
 1.00A 4y0rA-3crw1:
undetectable		 4y0rA-3crw1:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3crw XPD/RAD3 RELATED DNA
HELICASE
(Sulfolobus
acidocaldarius) 		4 / 7 VAL 1  15
LEU 1  27
MET 1 176
VAL 1 178
 None
 1.04A 5e4dA-3crw1:
undetectable
5e4dB-3crw1:
undetectable		 5e4dA-3crw1:
15.41
5e4dB-3crw1:
15.41