SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cs3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 8 LEU A  77
VAL A  64
LEU A 115
TYR A  74
 None
 0.94A 1jlbA-3cs3A:
undetectable		 1jlbA-3cs3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 11 GLY A 269
VAL A 272
GLU A 316
ASP A 237
ILE A 241
 None
 1.17A 1pk9C-3cs3A:
2.8		 1pk9C-3cs3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 10 ILE A 124
ASP A 138
LEU A 137
ILE A 294
ILE A 134
 None
 1.30A 1rb3A-3cs3A:
2.1		 1rb3A-3cs3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 8 LEU A  77
VAL A  64
LEU A 115
TYR A  74
 None
 0.92A 1s1xA-3cs3A:
undetectable		 1s1xA-3cs3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		3 / 3 ASP A 183
PHE A 209
ARG A 187
 GOL  A 401 (-3.7A)
GOL  A 401 ( 3.8A)
GOL  A 401 (-2.6A)
 0.78A 2a3aA-3cs3A:
undetectable		 2a3aA-3cs3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 8 GLY A 207
GLY A 214
ALA A 216
ALA A 217
 None
 0.59A 2ej3A-3cs3A:
undetectable		 2ej3A-3cs3A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 6 SER A 266
LEU A 268
SER A  72
ASP A 264
 None
None
None
GOL  A 401 (-3.0A)
 1.16A 2j2pE-3cs3A:
undetectable
2j2pF-3cs3A:
undetectable		 2j2pE-3cs3A:
20.49
2j2pF-3cs3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		3 / 3 VAL A 165
GLU A 194
GLU A 162
 None
 0.68A 2nv4A-3cs3A:
undetectable		 2nv4A-3cs3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 9 LEU A 195
ILE A 279
GLY A 262
ILE A 260
ILE A 161
 None
 1.07A 2r5qA-3cs3A:
undetectable		 2r5qA-3cs3A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 9 LEU A 195
ILE A 279
GLY A 262
ILE A 260
ILE A 161
 None
 1.07A 2r5qC-3cs3A:
undetectable		 2r5qC-3cs3A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 207
GLY A 177
ILE A 205
ALA A 216
GLU A 179
 None
 1.16A 2vdvE-3cs3A:
undetectable		 2vdvE-3cs3A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 11 GLY A 207
GLY A 177
ILE A 205
ALA A 216
GLU A 179
 None
 1.16A 2vdvF-3cs3A:
undetectable		 2vdvF-3cs3A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 11 GLY A 269
VAL A 272
GLU A 316
ASP A 237
ILE A 241
 None
 1.18A 3uawA-3cs3A:
undetectable		 3uawA-3cs3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 12 VAL A  94
ILE A 113
VAL A 149
ILE A 308
LEU A  78
 None
 1.32A 4a84A-3cs3A:
undetectable		 4a84A-3cs3A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 8 VAL A  64
TYR A  65
ILE A  62
ILE A  93
 None
 1.03A 4afgD-3cs3A:
undetectable
4afgE-3cs3A:
undetectable		 4afgD-3cs3A:
25.24
4afgE-3cs3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 5 GLY A 287
ILE A  81
TRP A 286
VAL A 149
 None
 1.15A 4d33A-3cs3A:
undetectable		 4d33A-3cs3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 5 GLY A 287
ILE A  81
TRP A 286
VAL A 149
 None
 1.15A 4d33B-3cs3A:
undetectable		 4d33B-3cs3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 8 GLY A  63
VAL A  64
PHE A 127
ILE A 134
 None
 0.87A 4fglD-3cs3A:
undetectable		 4fglD-3cs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 7 GLY A  63
VAL A  64
PHE A 127
ILE A 134
 None
 0.84A 4fglC-3cs3A:
5.3		 4fglC-3cs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 6 SER A  72
GLY A 207
ASP A 208
GLY A 214
 None
 1.01A 4koeA-3cs3A:
undetectable
4koeB-3cs3A:
undetectable
4koeC-3cs3A:
3.1		 4koeA-3cs3A:
21.43
4koeB-3cs3A:
21.43
4koeC-3cs3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 6 LEU A 115
ILE A 113
LEU A  77
TYR A  74
 None
 0.97A 4w5nA-3cs3A:
6.3		 4w5nA-3cs3A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 6 GLY A 207
ASP A 208
GLY A 214
SER A  72
 None
 0.99A 4z53A-3cs3A:
undetectable
4z53B-3cs3A:
undetectable		 4z53A-3cs3A:
16.96
4z53B-3cs3A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 7 GLY A  71
SER A  72
PHE A  73
LEU A  77
 None
None
GOL  A 401 (-4.5A)
None
 0.87A 5izfA-3cs3A:
undetectable		 5izfA-3cs3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A  66
ALA A  67
THR A 118
THR A 210
PRO A 178
 None
 1.18A 5k9dA-3cs3A:
undetectable		 5k9dA-3cs3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 12 VAL A 232
ASP A 237
ARG A 275
GLN A 273
ARG A 259
 None
 1.32A 5syfB-3cs3A:
undetectable		 5syfB-3cs3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		4 / 6 SER A 266
ARG A 187
PHE A 263
GLU A 238
 None
GOL  A 401 (-2.6A)
None
GOL  A 401 ( 4.9A)
 1.48A 5uo8A-3cs3A:
undetectable
5uo8B-3cs3A:
undetectable		 5uo8A-3cs3A:
20.40
5uo8B-3cs3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Enterococcus
faecalis) 		5 / 10 GLY A 111
VAL A  64
VAL A 135
ALA A 290
LEU A  85
 None
 1.00A 6czmA-3cs3A:
undetectable
6czmC-3cs3A:
undetectable		 6czmA-3cs3A:
24.38
6czmC-3cs3A:
24.38