SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3csk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 238
THR A 236
PRO A 240
 None
 0.83A 1a7yA-3cskA:
undetectable		 1a7yA-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 238
THR A 236
PRO A 240
 None
 0.73A 1a7yB-3cskA:
undetectable		 1a7yB-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 4 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.50A 1fbmB-3cskA:
undetectable		 1fbmB-3cskA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 4 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.67A 1fbmD-3cskA:
undetectable		 1fbmD-3cskA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 5 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.55A 1fbmE-3cskA:
undetectable		 1fbmE-3cskA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.14A 1gtnB-3cskA:
undetectable
1gtnC-3cskA:
undetectable		 1gtnB-3cskA:
7.05
1gtnC-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 1gtnH-3cskA:
undetectable
1gtnI-3cskA:
undetectable		 1gtnH-3cskA:
7.05
1gtnI-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.16A 1gtnM-3cskA:
undetectable
1gtnN-3cskA:
undetectable		 1gtnM-3cskA:
7.05
1gtnN-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.12A 1gtnU-3cskA:
undetectable
1gtnV-3cskA:
undetectable		 1gtnU-3cskA:
7.05
1gtnV-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 235
SER A 299
ASN A 211
THR A 212
 None
 1.25A 1h7xA-3cskA:
undetectable		 1h7xA-3cskA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 235
SER A 299
ASN A 211
THR A 212
 None
 1.22A 1h7xB-3cskA:
undetectable		 1h7xB-3cskA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 236
PRO A 240
THR A 238
 None
 0.80A 1i3wE-3cskA:
undetectable		 1i3wE-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 236
PRO A 240
THR A 238
 None
 0.84A 1i3wG-3cskA:
undetectable		 1i3wG-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 7 SER A  13
PRO A  11
SER A 428
ALA A 424
 None
 1.08A 1k5qA-3cskA:
undetectable
1k5qB-3cskA:
undetectable		 1k5qA-3cskA:
14.78
1k5qB-3cskA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  71
VAL A  91
LEU A  88
LEU A 707
LEU A 703
 None
 1.05A 1mx1F-3cskA:
undetectable		 1mx1F-3cskA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 4 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.68A 1mz9D-3cskA:
1.4		 1mz9D-3cskA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 236
PRO A 240
THR A 238
 None
 0.84A 1ovfB-3cskA:
undetectable		 1ovfB-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 238
THR A 236
PRO A 240
 None
 0.67A 1qfiB-3cskA:
undetectable		 1qfiB-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 526
ILE A 536
ILE A 533
LYS A 532
 None
 0.95A 1sbrB-3cskA:
undetectable		 1sbrB-3cskA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 238
THR A 236
PRO A 240
 None
 0.83A 1unjF-3cskA:
undetectable		 1unjF-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.14A 1utdT-3cskA:
undetectable
1utdU-3cskA:
undetectable		 1utdT-3cskA:
7.05
1utdU-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.90A 1v7zA-3cskA:
undetectable		 1v7zA-3cskA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.90A 1v7zB-3cskA:
undetectable		 1v7zB-3cskA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.91A 1v7zC-3cskA:
undetectable		 1v7zC-3cskA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 533
SER A 364
LEU A 527
ASN A 530
 None
 1.13A 1y0xX-3cskA:
undetectable		 1y0xX-3cskA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 SER A 682
VAL A 341
LEU A 388
 None
 0.55A 1yajG-3cskA:
undetectable		 1yajG-3cskA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 236
PRO A 240
THR A 238
 None
 0.66A 209dC-3cskA:
undetectable		 209dC-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  31
ASP A 686
ASN A 688
 None
 1.08A 2bm9A-3cskA:
undetectable		 2bm9A-3cskA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 462
ILE A 459
ILE A 523
ALA A 359
LEU A 355
 None
 1.13A 2m9qA-3cskA:
undetectable		 2m9qA-3cskA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 197
ILE A 224
PRO A 175
SER A 176
GLY A 186
 None
 1.07A 2qd4B-3cskA:
undetectable		 2qd4B-3cskA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 109
SER A  55
LEU A  98
 None
 0.79A 2w1bA-3cskA:
2.3		 2w1bA-3cskA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 201
VAL A 253
ILE A 214
GLU A 329
PHE A 255
 None
 1.18A 2weyA-3cskA:
undetectable		 2weyA-3cskA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 486
GLU A 373
TYR A 372
 None
 0.78A 2zmbA-3cskA:
undetectable		 2zmbA-3cskA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.92A 3a6jA-3cskA:
undetectable		 3a6jA-3cskA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.91A 3a6jB-3cskA:
undetectable		 3a6jB-3cskA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.91A 3a6jC-3cskA:
undetectable		 3a6jC-3cskA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.94A 3a6jE-3cskA:
undetectable		 3a6jE-3cskA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 517
HIS A 460
HIS A 465
GLU A 461
 ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 ( 4.0A)
 0.91A 3a6jF-3cskA:
undetectable		 3a6jF-3cskA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 141
SER A 137
HIS A 148
TRP A 225
 None
 1.13A 3arrA-3cskA:
undetectable		 3arrA-3cskA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 111
TYR A 163
ILE A 158
ILE A  62
ILE A  65
 None
 1.07A 3p4wB-3cskA:
undetectable		 3p4wB-3cskA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 111
TYR A 163
ILE A 158
ILE A  62
ILE A  65
 None
 1.07A 3p4wD-3cskA:
undetectable		 3p4wD-3cskA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 111
TYR A 163
ILE A 158
ILE A  62
ILE A  65
 None
 1.06A 3p4wE-3cskA:
undetectable		 3p4wE-3cskA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 578
HIS A 465
GLU A 517
HIS A 460
 None
ZN  A 712 (-3.3A)
ZN  A 712 (-2.3A)
ZN  A 712 (-3.3A)
 1.33A 4a7bB-3cskA:
undetectable		 4a7bB-3cskA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 709
VAL A 341
LEU A 340
SER A 339
 None
 1.32A 4e1gA-3cskA:
0.4		 4e1gA-3cskA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 612
PHE A 436
LEU A 601
VAL A 667
LEU A 561
 None
 1.22A 4g1bC-3cskA:
undetectable		 4g1bC-3cskA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  22
GLU A  20
ALA A 342
GLY A 419
LEU A 418
 None
 0.95A 4oaeA-3cskA:
undetectable		 4oaeA-3cskA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 634
HIS A 465
HIS A 460
GLU A 517
 None
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-2.3A)
 0.97A 4pahA-3cskA:
undetectable		 4pahA-3cskA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 325
THR A 326
HIS A 293
ASN A 320
 None
 1.09A 4pfjB-3cskA:
undetectable		 4pfjB-3cskA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 4 THR A 496
GLY A 488
ASP A 490
SER A 640
 None
MG  A 714 ( 4.9A)
MG  A 714 (-3.6A)
None
 1.40A 4rfqA-3cskA:
undetectable		 4rfqA-3cskA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eeuF-3cskA:
undetectable
5eeuG-3cskA:
undetectable		 5eeuF-3cskA:
7.05
5eeuG-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.12A 5eeuI-3cskA:
undetectable
5eeuJ-3cskA:
undetectable		 5eeuI-3cskA:
7.05
5eeuJ-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5eeuO-3cskA:
undetectable
5eeuP-3cskA:
undetectable		 5eeuO-3cskA:
7.05
5eeuP-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.18A 5eeuQ-3cskA:
undetectable
5eeuR-3cskA:
undetectable		 5eeuQ-3cskA:
7.05
5eeuR-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eevF-3cskA:
undetectable
5eevG-3cskA:
undetectable		 5eevF-3cskA:
7.05
5eevG-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eevI-3cskA:
undetectable
5eevJ-3cskA:
undetectable		 5eevI-3cskA:
7.05
5eevJ-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5eevO-3cskA:
undetectable
5eevP-3cskA:
undetectable		 5eevO-3cskA:
7.05
5eevP-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.19A 5eevQ-3cskA:
undetectable
5eevR-3cskA:
undetectable		 5eevQ-3cskA:
7.05
5eevR-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eewF-3cskA:
undetectable
5eewG-3cskA:
undetectable		 5eewF-3cskA:
7.05
5eewG-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eewI-3cskA:
undetectable
5eewJ-3cskA:
undetectable		 5eewI-3cskA:
7.05
5eewJ-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5eewO-3cskA:
undetectable
5eewP-3cskA:
undetectable		 5eewO-3cskA:
7.05
5eewP-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.19A 5eewQ-3cskA:
undetectable
5eewR-3cskA:
undetectable		 5eewQ-3cskA:
7.05
5eewR-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eexF-3cskA:
undetectable
5eexG-3cskA:
undetectable		 5eexF-3cskA:
7.05
5eexG-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5eexO-3cskA:
undetectable
5eexP-3cskA:
undetectable		 5eexO-3cskA:
7.05
5eexP-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eeyF-3cskA:
undetectable
5eeyG-3cskA:
undetectable		 5eeyF-3cskA:
7.05
5eeyG-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5eeyO-3cskA:
undetectable
5eeyP-3cskA:
undetectable		 5eeyO-3cskA:
7.05
5eeyP-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5eezF-3cskA:
undetectable
5eezG-3cskA:
undetectable		 5eezF-3cskA:
7.05
5eezG-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5eezO-3cskA:
undetectable
5eezP-3cskA:
undetectable		 5eezO-3cskA:
7.05
5eezP-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5ef0F-3cskA:
undetectable
5ef0G-3cskA:
undetectable		 5ef0F-3cskA:
7.05
5ef0G-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5ef0O-3cskA:
undetectable
5ef0P-3cskA:
undetectable		 5ef0O-3cskA:
7.05
5ef0P-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5ef1F-3cskA:
undetectable
5ef1G-3cskA:
undetectable		 5ef1F-3cskA:
7.05
5ef1G-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5ef1O-3cskA:
undetectable
5ef1P-3cskA:
undetectable		 5ef1O-3cskA:
7.05
5ef1P-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5ef2F-3cskA:
undetectable
5ef2G-3cskA:
undetectable		 5ef2F-3cskA:
7.05
5ef2G-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5ef2O-3cskA:
undetectable
5ef2P-3cskA:
undetectable		 5ef2O-3cskA:
7.05
5ef2P-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  42
GLY A 322
ALA A  39
THR A 391
ILE A 321
 None
 1.13A 5ef3F-3cskA:
undetectable
5ef3G-3cskA:
undetectable		 5ef3F-3cskA:
7.05
5ef3G-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 322
ALA A  39
THR A 391
ILE A 321
ALA A  42
 None
 1.15A 5ef3O-3cskA:
undetectable
5ef3P-3cskA:
undetectable		 5ef3O-3cskA:
7.05
5ef3P-3cskA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 257
GLY A 258
THR A 236
PHE A 202
 None
 0.96A 5flcB-3cskA:
2.7		 5flcB-3cskA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 257
GLY A 258
THR A 236
PHE A 202
 None
 0.95A 5flcF-3cskA:
2.7		 5flcF-3cskA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 111
TYR A 163
ILE A 158
ILE A  62
ILE A  65
 None
 0.98A 5murE-3cskA:
undetectable		 5murE-3cskA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 341
PHE A 294
LEU A 287
LEU A 271
VAL A 267
 None
 1.17A 5tudA-3cskA:
3.6		 5tudA-3cskA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  53
SER A 181
ARG A 213
 None
 0.98A 5u63A-3cskA:
undetectable		 5u63A-3cskA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 538
TYR A  21
ASP A 451
TYR A 448
 None
 0.89A 5vlmG-3cskA:
undetectable		 5vlmG-3cskA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 445
GLY A 552
GLN A 555
LEU A 599
ILE A 619
 None
 1.21A 5y2tA-3cskA:
undetectable		 5y2tA-3cskA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 136
ILE A 158
LEU A 124
ALA A 125
 None
 0.73A 5y7pC-3cskA:
undetectable		 5y7pC-3cskA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 108
ASN A 100
SER A  52
 None
 1.07A 5yw0A-3cskA:
undetectable		 5yw0A-3cskA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  63
ALA A  64
ARG A  45
ILE A 162
LEU A 122
 None
 1.41A 6cbzB-3cskA:
undetectable		 6cbzB-3cskA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 634
HIS A 465
HIS A 460
GLU A 517
 None
ZN  A 712 (-3.3A)
ZN  A 712 (-3.3A)
ZN  A 712 (-2.3A)
 0.83A 6pahA-3cskA:
undetectable		 6pahA-3cskA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 422
ARG A 348
PHE A 382
SER A 384
PHE A 453
 None
 1.24A 6qgbA-3cskA:
undetectable		 6qgbA-3cskA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_C_BEZC701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 422
ARG A 348
PHE A 382
SER A 384
PHE A 453
 None
 1.25A 6qgbC-3cskA:
0.1		 6qgbC-3cskA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 422
ARG A 348
PHE A 382
SER A 384
PHE A 453
 None
 1.24A 6qgbF-3cskA:
undetectable		 6qgbF-3cskA:
20.75